Results 201 to 210 of about 9,774,870 (350)

Antitumor efficacy of intermittent low‐dose erlotinib plus sulindac via MHC upregulation and remodeling of the immune cell niche

open access: yesInternational Journal of Cancer, EarlyView.
What's New? Novel immunomodulatory insights derived from experimental models and clinical samples reveal the cancer‐preventive potential of intermittent low‐dose erlotinib plus sulindac (ERL + SUL). This study shows that ERL + SUL treatment upregulates MHC class I and II expression and remodels the immune cell niche, with significant tumor suppression ...
Chakrapani Tripathi   +17 more
wiley   +1 more source

Exploring the Role of T‐Cell Metabolism in Modulating Immunotherapy Efficacy for Non‐Small Cell Lung Cancer Based on Clustering

open access: yesJournal of Clinical Laboratory Analysis, EarlyView.
We conducted a comprehensive investigation of the metabolic profiles of infiltrating T cells in NSCLC tumors and found metabolic heterogeneity in three T‐cell subtypes, which are associated with the prognosis of ICB therapy. We defined these metabolic clusters as response‐dependent (R) clusters and non‐response‐dependent (NR) clusters, and elucidated ...
Hongzhe Guo   +7 more
wiley   +1 more source

Moderate hyperuricaemia ameliorated kidney damage in a low‐renin model of experimental renal insufficiency

open access: yesBasic &Clinical Pharmacology &Toxicology, Volume 132, Issue 1, Page 21-32, January 2023., 2023
Abstract Uric acid has promoted renal fibrosis and inflammation in experimental studies, but some studies have shown nephroprotective effects due to alleviated oxidative stress. We studied the influence of experimental hyperuricaemia in surgically 5/6 nephrectomized rats. Three weeks after subtotal nephrectomy or sham operation, the rats were allocated
Venla Kurra   +9 more
wiley   +1 more source

Leishmania braziliensis prostaglandin F synthase impacts host infection. [PDF]

open access: yesParasit Vectors, 2020
Alves-Ferreira EVC   +4 more
europepmc   +1 more source

The anthocyanin‐enriched extract of Vaccinium corymbosum exerted in vitro and ex vivo antiproliferative and anti‐inflammatory activities

open access: yesJSFA reports, EarlyView.
Abstract Background Vaccinium corymbosum berries represent a source of anthocyanins and polyphenols studied and tested for their healthy potential. The present study was aimed at isolating, characterizing, and quantifying the anthocyanin‐enriched fraction obtained from blueberry and at assessing its biological and protective effects against head and ...
Giuseppe Falcone   +11 more
wiley   +1 more source

The effects of acetylsalicylic acid on performance, carcass traits, breast meat quality and white striping muscle defects in broiler chickens

open access: yesJournal of the Science of Food and Agriculture, EarlyView.
Abstract BACKGROUND This research aims to reduce white striping muscle defects induced by vascular inflammation and hypoxia using the anti‐inflammatory, antiplatelet and anti‐atherothrombotic properties of acetylsalicylic acid (ASA). To this end, the effects of different doses (0.3, 0.6, 1, 3 and 6 g L−1) of ASA added to drinking water at 24–48 days on
Gülşah Güngören   +9 more
wiley   +1 more source

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