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Conformations of Prostaglandin F 2α and Recognition of Prostaglandins by Their Receptors [PDF]
Science, 1977 The conformation of prostaglandin F 2α (PGF 2α ) has been determined by x-ray diffraction techniques. Two independent conformers of PGF 2α , studied as the tris(hydroxymethyl)methylamine salt, are observed to adopt the familiar "hairpin" conformation with the α and ω ...
Mary Erman +2 more
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Amide and l-amino derivatives of F prostaglandins as prostaglandin antagonists
Nature, 1978THE formation in tissues and organs of the different prostaglandins (PGs) is now known to be associated with various pathophysiological situations. There is an urgent need for specific PG antagonists to facilitate experimental differentiation and analysis of the roles of these endogenous PGs.
Y T Maddox +3 more
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Simple direct radioimmunoassay of the F prostaglandins
Prostaglandins, 1974Abstract A simplified and accurate method of determining the F prostaglandins in 0.1 ml of serum without previous extraction is described. The procedure involves addition of anti-prostaglandin F2α to serum followed by tritiated prostaglandin, equilibration for 4 hours, removal of unbound prostaglandin with dextran-coated charcoal and subsequent ...
Elizabeth Walker +3 more
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Novel synthesis of prostaglandin F2.alpha.
Journal of the American Chemical Society, 1973AbstractDas aus dem Triol (I) mit Glyoxylsäuremonohydrat erhaltene tricyclische La ton (II) wird zum Diol (IIIa) reduziert.
R. Sitrin +8 more
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Prostaglandins, 1978
Abstract The relationship between progesterone (P 4 ) synthesis in vitro by luteal tissue and prostaglandin F (PGF) synthesis in vitro by endometrium and luteal tissue from two stages of the cycle, Days 7 to 8 and 15 to 16, was determined.
Caird E. Rexroad +2 more
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Abstract The relationship between progesterone (P 4 ) synthesis in vitro by luteal tissue and prostaglandin F (PGF) synthesis in vitro by endometrium and luteal tissue from two stages of the cycle, Days 7 to 8 and 15 to 16, was determined.
Caird E. Rexroad +2 more
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Prostaglandins & Other Lipid Mediators, 2002
Prostaglandin (PG) F2 is synthesized via three pathways from PGE2, PGD2, or PGH2 by PGE 9-ketoreductase, PGD 11-ketoreductase, or PGH 9-, 11-endoperoxide reductase, respectively. The enzymological and molecular biological properties of these enzymes have been reported in work over the last 30 years.
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Prostaglandin (PG) F2 is synthesized via three pathways from PGE2, PGD2, or PGH2 by PGE 9-ketoreductase, PGD 11-ketoreductase, or PGH 9-, 11-endoperoxide reductase, respectively. The enzymological and molecular biological properties of these enzymes have been reported in work over the last 30 years.
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Histochemistry and Cell Biology, 2007
In order to promote better understanding of the physiological roles of prostaglandin F(2alpha) in the mouse testis, we investigated the protein expression and the cellular localization of the enzymes cyclooxygenase and prostaglandin F synthase that are essential for the production of prostaglandin F(2alpha), and the binding site, which is the ...
Yukihiko Sugimoto +3 more
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In order to promote better understanding of the physiological roles of prostaglandin F(2alpha) in the mouse testis, we investigated the protein expression and the cellular localization of the enzymes cyclooxygenase and prostaglandin F synthase that are essential for the production of prostaglandin F(2alpha), and the binding site, which is the ...
Yukihiko Sugimoto +3 more
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Prostaglandins, 1974
Abstract Antibodies to both prostaglandin F (PGF) and prostaglandin E (PGE) were raised in rabbits after they were immunized with prostaglandin F2a conjugated to bovine serum albumin (PGF2a - BSA). The antisera were group specific although the antibodies to the F group of prostaglandins showed greater specificity than those to the E group.
Warren R. Jones +4 more
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Abstract Antibodies to both prostaglandin F (PGF) and prostaglandin E (PGE) were raised in rabbits after they were immunized with prostaglandin F2a conjugated to bovine serum albumin (PGF2a - BSA). The antisera were group specific although the antibodies to the F group of prostaglandins showed greater specificity than those to the E group.
Warren R. Jones +4 more
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ChemInform Abstract: STEREOSELECTIVE REDUCTION OF PROSTAGLANDINS E TO PROSTAGLANDINS F
Chemischer Informationsdienst, 1980AbstractDie Prostaglandine E (I) gehen bei der Reduktion mit Li in Tetrahydrofuran und flüssigem Ammoniak in die Prostaglandine Fß(II) über.
K. K. Pivnitskii, V. I. Mel'nikova
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A radioimmunoassay for the initial metabolites of the F prostaglandins
Prostaglandins, 1973Abstract Antibodies to the F metabolite 9α, 11α-dihydro-15-keto-prostanoic acid (I), produced in the rabbit, do not cross react with any of the primary PGs. There is a 50% cross reaction with the metabolite 9α, 11α-dihydroxy-15-keto-prost-5-enoic acid (III), and a 23% cross reaction with 9α,11α,15-trihydroxy prostanoic acid (F0α). No cross reactivity
Earl M. Ritzi +4 more
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