Results 331 to 340 of about 365,133 (358)

Co-localization of prostaglandin F synthase, cyclooxygenase-1 and prostaglandin F receptor in mouse Leydig cells

Histochemistry and Cell Biology, 2007
In order to promote better understanding of the physiological roles of prostaglandin F(2alpha) in the mouse testis, we investigated the protein expression and the cellular localization of the enzymes cyclooxygenase and prostaglandin F synthase that are essential for the production of prostaglandin F(2alpha), and the binding site, which is the ...
Yukihiko Sugimoto, Toshiko Suzuki-Yamamoto, Atsushi Ichikawa, Kazunori Ishimura   +3 more
openaire   +3 more sources

Utilization of a single antiserum for the direct radioimmunoassay of prostaglandins E and F in semen and prostaglandin F in amniotic fluid

Prostaglandins, 1974
Abstract Antibodies to both prostaglandin F (PGF) and prostaglandin E (PGE) were raised in rabbits after they were immunized with prostaglandin F2a conjugated to bovine serum albumin (PGF2a - BSA). The antisera were group specific although the antibodies to the F group of prostaglandins showed greater specificity than those to the E group.
Warren R. Jones, Donald A. Shutt, R.M.Y. Ing, Derek Llewellyn-Jones, Alan H. Clarke   +4 more
openaire   +3 more sources

ChemInform Abstract: STEREOSELECTIVE REDUCTION OF PROSTAGLANDINS E TO PROSTAGLANDINS F

Chemischer Informationsdienst, 1980
AbstractDie Prostaglandine E (I) gehen bei der Reduktion mit Li in Tetrahydrofuran und flüssigem Ammoniak in die Prostaglandine Fß(II) über.
K. K. Pivnitskii, V. I. Mel'nikova
openaire   +2 more sources

A radioimmunoassay for the initial metabolites of the F prostaglandins

Prostaglandins, 1973
Abstract Antibodies to the F metabolite 9α, 11α-dihydro-15-keto-prostanoic acid (I), produced in the rabbit, do not cross react with any of the primary PGs. There is a 50% cross reaction with the metabolite 9α, 11α-dihydroxy-15-keto-prost-5-enoic acid (III), and a 23% cross reaction with 9α,11α,15-trihydroxy prostanoic acid (F0α). No cross reactivity
Earl M. Ritzi, Sumner H. Burstein, Jack Rosenfeld, David J. Watson, William A. Stylos   +4 more
openaire   +2 more sources

Synthetic Modification of Prostaglandin F2α Indicates Different Structural Determinants for Binding to the Prostaglandin F Receptor Versus the Prostaglandin Transporter [PDF]

Molecular Pharmacology, 2000
Several principles governing the binding of E series prostaglandins to EP receptors have emerged in recent years. The C-1 carboxyl group binds electrostatically to a conserved arginine residue in the seventh transmembrane segment of the receptor. Prostaglandin E analogs involving bioisosteric replacements of the carboxyl group, such as acylsulfonamide,
June Chen, Robert M. Burk, Shigekazu Itoh, Steven W. Andrews, Karen M. Kedzie, Daniel W. Gil, Victor L. Schuster, David F. Woodward   +7 more
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Roles of Prostaglandin F Synthase

2001
Prostaglandin (PG) F2 is widely distributed in various organs, and exhibits various biological actions such as smooth muscle contraction of uterus [1], bronchus [2], and trachea [3], the initiation of parturition [4], and pain transmission [5]. PGF synthase (PGFS) is a dual function enzyme, which catalyzes the reduction of not only PGD2 but also PGH2 ...
Motonari Fukui, Toshiko Suzuki-Yamamoto, Mikio Nishizawa, Seiji Ito, Kazunori Ishimura, Kikuko Watanabe   +5 more
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Intramyometrial prostaglandin F2α

American Journal of Obstetrics and Gynecology, 1972
Abstract Hypertonic saline and prostaglandin F 2α were injected into pregnant monkey myometrium. Small volumes of 20 per cent saline produced full-thickness myometrial necrosis with hemorrhage and thrombosis. PGF 2α in amounts sufficient to induce uterine contractions caused no histologic change.
Theodore M. King, Anne Colston Wentz
openaire   +3 more sources

The distribution of prostaglandins A, E, and F in the human kidney

Prostaglandins, 1974
Abstract Using recently developed radioimmunoassay techniques, prostaglandin concentrations were measured in two human cadaver kidneys which had been processed for transplantation but for which no recipient patients could be obtained. Portions of cortex, medulla, papilla, and ureter were obtained from each kidney.
Burton V. Caldwell, Randall M. Zusman, Leon Speroff, David Spector   +3 more
openaire   +3 more sources

Relationship between Prostaglandin F and Steroids in Human Peripheral Venous Plasma and Concentration of Prostaglandin F in Corpus Luteum

Asia-Oceania Journal of Obstetrics and Gynaecology, 1984
AbstractConcentrations of prostaglandin F and steroids in plasma and in corpus luteum (CL) were studied by radioimmunoassay during the luteal phase of the menstrual cycle in thirteen normal women.The average concentration of PGF in corpus luteum was 4.19 ± 1.59 ng/g (mean ± SE) (ranging from 0.03 to 20.5 ng/g) and in plasma was 208.1 ± 34.7 pg/ml ...
Shoichi Tanaka, Hiroshi Hata, Yasuharu Shimoya, Hiroshi Yamamoto, Hiroshi Yamamoto, Masayoshi Hashimoto   +5 more
openaire   +3 more sources

Failure of Parturition in Mice Lacking the Prostaglandin F Receptor [PDF]

Science, 1997
Mice lacking the gene encoding the receptor for prostaglandin F 2α (FP) developed normally but were unable to deliver normal fetuses at term. Although these FP-deficient mice showed no abnormality in the estrous cycle, ovulation, fertilization, or implantation, they did not respond to exogenous oxytocin because of ...
Eri Segi, Takashi Tanaka, Shuh Narumiya, Takahiko Murata, Nobuaki Yoshida, Kazuhito Tsuboi, Masakazu Hirata, Hiroji Oida, Ken Yuh Hasumoto, Manabu Negishi, Yukihiko Sugimoto, Atsushi Yamasaki, Atsushi Ichikawa, Tatsuya Nishimura, Masato Katsuyama, Fumitaka Ushikubi, Yoshiya Aze   +16 more
openaire   +2 more sources