Results 31 to 40 of about 9,739,564 (270)

Human prostaglandin EP3 receptor isoforms show different agonist-induced internalization patterns [PDF]

, 2004
The human prostaglandin EP3 receptor comprises eight isoforms that differ in carboxyl-tail. We show here that the isoforms are trafficked differently. When expressed in HEK293 cells, the isoforms located to the cell surface, although a fraction of some ...
Ashby, Barrie, Bilson, Heather A, Mitchell, Deanah L   +2 more
core   +1 more source

Application of N-Dodecyl l-Peptide to Enhance Serum Stability while Maintaining Inhibitory Effects on Myometrial Contractions Ex Vivo

Molecules, 2019
N-Alkylation and N-acylation of the prostaglandin-F2α allosteric modulator l-PDC31 were performed to install various alkyl, PEG and isoprenoid groups onto the l-enantiomer of the peptide.
Julien Poupart, Xin Hou, Sylvain Chemtob, William D. Lubell   +3 more
doaj   +1 more source

Pretreatment of Garlic Oil Extracts Hampers Epithelial Damage in Cell Culture Model of Peptic Ulcer Disease

Medicina, 2022
Background and Objectives: Peptic ulcer disease is a chronic disease affecting up to 10% of the world’s population. Proton pump inhibitors, such as lansoprazole are the gold standard in the treatment of ulcer disease.
Lucija Kuna, Milorad Zjalic, Tomislav Kizivat, Hrvoje Roguljic, Vjera Nincevic, Tea Omanovic Kolaric, Catherine H. Wu, Aleksandar Vcev, Martina Smolic, Robert Smolic   +9 more
doaj   +1 more source

Molecular simulation-based evaluation of anti-inflammatory properties of natural compounds derived from tobacco (Nicotiana tabacum L.): Computational multi-target approaches [PDF]

Pharmacia
Various components of the tobacco plant (Nicotiana tabacum L.) have undergone pharmacological assessment to highlight their traditional role in addressing different health conditions.
Vinda Maharani Patricia, Aulia Fikri Hidayat, Taufik Muhammad Fakih   +2 more
doaj   +3 more sources

Attenuation of ischemic liver injury by prostaglandin E1 analogue, misoprostol, and prostaglandin I2 analogue, OP-41483 [PDF]

, 1998
Background: Prostaglandin has been reported to have protective effects against liver injury. Use of this agent in clinical settings, however, is limited because of drugrelated side effects.
Ishizaki, N, Jin, MB, Kawashima, Y, Shimamura, T, Starzl, TE, Todo, S, Totsuka, E, Urakami, A, Zhu, Y   +8 more
core   +1 more source

The effect of agility exercise on eicosanoid excretion, oxidant status, and plasma lactate in dogs

BMC Veterinary Research, 2012
Background The objective was to determine the effects of agility exercise on dogs of different skill levels with respect to urinary eicosanoids, urinary 15F2t-isoprostane (lipid peroxidation marker) and hematological/biochemical changes in plasma ...
Baltzer Wendy I, Firshman Anna M, Stang Bernadette, Warnock Jennifer J, Gorman Elena, McKenzie Erica C   +5 more
doaj   +1 more source

Inhibitors of Oxidative Phosphorylation Modulate Astrocyte Inflammatory Responses through AMPK-Dependent Ptgs2 mRNA Stabilization

Cells, 2019
Inflammatory activation of astroglia adds to the pathology of various neurological diseases. Astrocytes respond to microglia-derived cytokines such as interleukin-1α (IL-1α) with enhanced inflammatory signaling.
Alina Astakhova, Dmitry Chistyakov, Dominique Thomas, Gerd Geisslinger, Bernhard Brüne, Marina Sergeeva, Dmitry Namgaladze   +6 more
doaj   +1 more source

Effects of benzene, quercetin, and their combination on porcine ovarian cell proliferation, apoptosis, and hormone release [PDF]

Archives Animal Breeding, 2019
We hypothesized that the environmental contaminant benzene and the plant antioxidant quercetin may affect ovarian cell functions and that quercetin could offer protection against the adverse effects of benzene.
A. Tarko, A. Štochmal'ová, K. Jedličková, S. Hrabovszká, A. Vachanová, A. H. Harrath, S. Alwasel, A. Alrezaki, J. Kotwica, A. Baláži, A. V. Sirotkin, A. V. Sirotkin   +11 more
doaj   +1 more source

Effects of prostaglandin F(2α) on adipocyte biology relevant to graves' orbitopathy.

Thyroid, 2013
BACKGROUND In Graves' orbitopathy (GO), increased proliferation, excess adipogenesis, and hyaluronan overproduction produce GO exophthalmos. Enophthalmos occurs in some glaucoma patients treated with Bimatoprost (prostaglandin F2α, PGF2α) eye drops.
M. Draman, F. Grennan-Jones, Lei Zhang, P. Taylor, T. K. Tun, J. McDermott, P. Moriarty, D. Morris, C. Lane, S. Sreenan, C. Dayan, M. Ludgate   +11 more
semanticscholar   +1 more source

Ascorbic acid enhances the inhibitory effect of aspirin on neuronal cyclooxygenase-2-mediated prostaglandin E2 production. [PDF]

, 2006
Inhibition of neuronal cyclooxygenase-2 (COX-2) and hence prostaglandin E2 (PGE2) synthesis by non-steroidal anti-inflammatory drugs has been suggested to protect neuronal cells in a variety of pathophysiological situations including Alzheimer's disease ...
Akundi, Ravi S., Appel, Kurt, Bhatia, Harsharan S., Candelario-Jalil, Eduardo, Fiebich, Bernd L., Hull, Michael, Lieb, Klaus, Munoz, Eduardo   +7 more
core   +1 more source