Results 241 to 250 of about 858,181 (296)

Genome‐Wide CRISPR Screen Reveals PIK3CA Inhibition Enhances Lipid Nanoparticle‐Mediated siRNA Delivery

Advanced Science, EarlyView.
A genome‐wide CRISPR screen and identifies PIK3CA as a key regulator of lipid nanoparticle (LNP) uptake is performed. Modulating PIK3CA with small‐molecule inhibitor BAY1082439 enhanced LNP uptake, siRNA delivery, and gene silencing in a variety of epithelial cells, and improved therapeutic outcomes in vivo.
Wenhan Wang, Kangfu Chen, Zongjie Wang
wiley   +1 more source

Impact of In-Office Dispensing Adoption by Urology Practices on Oral Specialty Drug Use in Advanced Prostate Cancer. [PDF]

Cancer Med
Faraj KS, Oerline M, Kaufman SR, Dall C, Srivastava A, Liu X, Caram MEV, Shahinian VB, Hollenbeck BK.   +8 more
europepmc   +1 more source

Frequency of Adenocarcinoma in Transrectal Ultrasound-guided Prostate Needle Biopsies in Men with Clinical Suspicion of Prostate Cancer and Raised Serum Prostate Specific Antigen

, 2013
Rahma Rashid, Muhammed Mubarak, Javed l. Kazi   +2 more
openalex   +1 more source

Comparative Single‐Cell Transcriptomic Atlas Reveals the Genetic Regulation of Reproductive Traits

Advanced Science, EarlyView.
A cross‐species single‐cell transcriptomic atlas of reproductive and central nervous system tissues from sheep and humans reveals conserved cellular programs and regulatory networks that regulated fertility. Integration with GWAS for sheep lifetime average litter size identifies UNC5–SLIT–BMP signaling as a core pathway coordinating neuroendocrine ...
Bingru Zhao, Hanpeng Luo, Dailu Guan, Xuefeng Fu, Feng Wang, Guoming Zhang, Shanglai Li, Hua Yang, Yanli Zhang   +8 more
wiley   +1 more source

Retraction: Mitostatin is down-regulated in human prostate cancer and suppresses the invasive phenotype of prostate cancer cells. [PDF]

PLoS One
PLOS One Editors.
europepmc   +1 more source

His‐MMDM: Multi‐Domain and Multi‐Omics Translation of Histopathological Images with Diffusion Models

Advanced Science, EarlyView.
His‐MMDM is a diffusion model‐based framework for scalable multi‐domain and multi‐omics translation of histopathological images, enabling tasks from virtual staining, cross‐tumor knowledge transfer, and omics‐guided image editing. ABSTRACT Generative AI (GenAI) has advanced computational pathology through various image translation models.
Zhongxiao Li, Tianqi Su, Bin Zhang, Wenkai Han, Sibin Zhang, Guiyin Sun, Yuwei Cong, Xin Chen, Jiping Qi, Yujie Wang, Shiguang Zhao, Hongxue Meng, Peng Liang, Xin Gao   +13 more
wiley   +1 more source

Assessment of miRNA 106a-5p and 375-3p Expression in the Context of the Wnt/β-Catenin Pathway-Comparison of Prostate Adenocarcinoma and Benign Prostatic Hyperplasia Tissues. [PDF]

Int J Mol Sci
Smereczańska M, Domian N, Młynarczyk G, Kasacka I.   +3 more
europepmc   +1 more source

Referral Network Increases Physicians’ Adoption of Active Surveillance for Localized Prostate Cancer: A Cross-Sectional Study Using SEER-Medicare

Yu Liu, David H. Howard, Ya‐Chen Tina Shih   +2 more
openalex   +1 more source

ZDHHC9 and spermine metabolism: a palmitoylation-driven pathway to prostate carcinogenesis. [PDF]

J Transl Med
Chen C, Zhang Y, Wang G, Liu Y, Ye B, Zhou S, Wang K, Zheng H, Dong X, Luo C, Zhou J, Zeng K, Fang C, Shen L.   +13 more
europepmc   +1 more source

Real-world Inter-rater Agreement of PI-QUAL Version 2 for Prostate Magnetic Resonance Imaging Quality Assessment and Its Association with Diagnostic Accuracy. [PDF]

Eur Urol Open Sci
van den Kroonenberg DL, Barentsz J, Hamstra BJ, van den Bosch SM, Gijsbertsen JJ, Reitsma JB, Brembilla G, Caglic I, Raat HPJ, de Rooij M, Postema AW, Giganti F, Oddens JR.   +12 more
europepmc   +1 more source