Results 241 to 250 of about 1,476,150 (337)

Pathogenesis-Guided Biomarker Assessment: A Shift in Prostate Cancer Diagnostics. [PDF]

Int J Mol Sci
Logan JM, Malone V, O'Leary JJ, Brooks DA.   +3 more
europepmc   +1 more source

CD168 Identifies Proliferating Pancreatic Islet Cells in Murine and Human

Advanced Science, EarlyView.
This study identifies CD168 as a conserved surface marker for proliferating β‐cells in mouse, human islets, and pancreatic islet tumors. CD168⁺ cells show high proliferation and low insulin expression. CD168+ cells form mostly uni‐β lineage clones, and some of the clones are multi‐lineage.
Shubo Yuan, Jiafu Li, Min Shao, Haili Bao, Ajun Geng, Jialin Yang, Yu Tao, Xinyi Chen, Tianxiong Xiao, Chunye Liu, Zhiyao Xie, Wenqian Song, Qing Cissy Yu, Hongxing Fu, Xu Han, Taochen He, Wenquan Wang, Jianfeng Chen, Sheng Yan, Shaohua Song, Liang Liu, Yi Arial Zeng   +21 more
wiley   +1 more source

Prostogrit mitigates testosterone/estradiol induced prostatic enlargement/remodeling in rat model of benign prostatic hyperplasia and fine-tunes prostatic expression of <i>Adra1a</i> and <i>Il6</i> genes. [PDF]

Front Endocrinol (Lausanne)
Balkrishna A, Sinha S, Pamidiboina V, Tomer M, Singh R, Dev R, Varshney A.   +6 more
europepmc   +1 more source

Arades Trial: A First-in-Man, Open-Label, Phase I/II Safety, Pharmacokinetic, and Proof-of-Concept Study of ODM-201 in Patients (PTS) with Progressive Metastatic Castration-Resistant Prostate Cancer (MCRPC)

, 2012
Christophe Massard, Nicholas D. James, Stéphane Culine, Robert H. Jones, Annamari Vuorela, Mika Mustonen, Karim Fizazi   +6 more
openalex   +1 more source

Targeting Itga8 Mitigates Neurogenic Bladder Fibrosis Driven by Trem2⁺ Macrophage‐Derived Fn1 via FAK/RhoA/ROCK Signaling

Advanced Science, EarlyView.
Normal bladders exhibit quiescent fibroblasts/macrophages, whereas neurogenic bladders show acute‐phase Itga8⁺ fibroblast expansion driven by Trem2⁺ macrophage‐secreted Fn1, which activates FAK/RhoA/ROCK signaling, promotes cytoskeletal remodeling, and upregulates pro‐fibrotic genes.
Jiaxin Wang, Siyuan Wang, Lida Ren, Xinqi Liu, Lei Zhang, Peng Hu, Wenchao Xu, Shuaixiang Zheng, Jihong Liu, Qing Ling   +9 more
wiley   +1 more source

Advances in prostate cancer treatment with moderate and ultra-hypofractionated radiotherapy. [PDF]

World J Clin Oncol
Meng LL, Di YP, Ma L, Qu BL.
europepmc   +1 more source

FXYD3 Promotes Tumor Progression by Binding With IRF7 to Regulate JAK2/STAT5 Signaling in Intrahepatic Cholangiocarcinoma

Advanced Science, EarlyView.
FXYD3 binds IRF7 via its 60–87aa domain, triggering a cGAS/STING‐mediated positive feedback loop amplified by type I interferon. This sustains JAK2/STAT5 activation, accelerating ICC progression. Targeting FXYD3 with siFXYD3@PEP suppresses tumors and enhances chemotherapy sensitivity. Abstract Intrahepatic cholangiocarcinoma (ICC) has a poor prognosis,
Yan Zhou, Xiaofeng Shen, Shuo Zhang, XiaoHong Pu, Zipeng Xu, Xiang Zhao, Wei Feng, Yuan Liang, Xingtao He, Aihua Yang, Yudong Qiu, Yihang Yuan, Chaobo Chen, Jun Chen   +13 more
wiley   +1 more source

Cumulative incidence and risk factors for medication-related osteonecrosis of the jaw during long-term prostate cancer management [PDF]

Masaru Tani, Koji Hatano, Akihiro Yoshimura, Yuki Horibe, Yutong Liu, Nesrine Sassi, Toshiki Oka, Yohei Okuda, Akinaru Yamamoto, Toshihiro Uemura, Gaku Yamamichi, Yu Ishizuya, Yoshiyuki Yamamoto, Taigo Kato, Atsunari Kawashima, Norio Nonomura   +15 more
openalex   +1 more source

LMO7 Suppresses Tumor‐Associated Macrophage Phagocytosis of Tumor Cells Through Degradation of LRP1

Advanced Science, EarlyView.
LMO7 in tumor‐associated macrophages suppresses phagocytosis of tumor cells and limits cytotoxic T lymphocytes infiltration, fostering tumor progression. Mechanistically, LMO7 mediates the ubiquitination and degradation of the phagocytic receptor LRP1, impairing its ability to engulf tumor cells and driving macrophages toward an antitumor phenotype ...
Mengkai Li, Tao Wang, Yuwen Zhong, Zhiming Wang, Wei Li, Zejian Wang, Xinyi Yang, Yu Qiao, Jianfeng Xiang, Wei Gu, Zishu Wang, Lei Sun, Feng Qian   +12 more
wiley   +1 more source