Results 191 to 200 of about 5,580,325 (291)

The Governance Gap: Democratizing Drug Development Through Decision Architecture

Clinical Pharmacology &Therapeutics, EarlyView.
Drug development is most exposed to governance failure where it can least afford it, in global health. The field has more predictive power than at any point in its history and roughly the same failure rate it had a decade ago. We argue that this paradox persists because the field has invested heavily in prediction science while neglecting decision ...
Craig R. Rayner, Nancy E. Martin, Danielle Smith, Eliza Kruger, Carl M.J. Kirkpatrick, Goonaseelan (Colin) Pillai, Katy Moore, Darrell Nix, Cristina Donini, Jakob P. Cramer, Edmundo Muniz, Natalia Muniz, Ernst Bos, Douglas McNair, Shyam Bhaskaran, Mark Sullivan, Dan Hartman   +16 more
wiley   +1 more source

Staged Full-Arch Rehabilitation With Tilted and Pterygoid Implants: A Pragmatic Hybrid Analog-Digital Workflow With 2-Year Follow-Up. [PDF]

Case Rep Dent
Liborio F, Sciarra FM, Di Vita E, Nigliaccio S, Fontana DA, Messina P, Cumbo EM, Scardina GA.   +7 more
europepmc   +1 more source

Transendocardial injection of expanded autologous CD34+ cells after myocardial infarction: Design of the EXCELLENT trial

ESC Heart Failure, Volume 12, Issue 2, Page 1455-1463, April 2025.
Abstract Aims The extent of irreversible cardiomyocyte necrosis after acute myocardial infarction (AMI) is a major determinant of residual left ventricular (LV) function and clinical outcome. Cell therapy based on CD34+ cells has emerged as an option to help repair the myocardium and to improve outcomes.
Jerome Roncalli, François Roubille, Nicolas Meyer, Giulio Pompilio, Lionel Leroux, Philippe Henon, Guillaume Trebuchet, Anthony Criquet, Matthieu de Kalbermatten, Eric Saloux, Alain Manrique, Pierre‐Yves Marie, Deepak L. Bhatt, Scott D. Solomon, Gilles Montalescot, David E. Newby, Faiez Zannad, on behalf of the EXCELLENT Trial Investigators   +17 more
wiley   +1 more source

The Expanding Role of Diazirines in Synthetic Methodology

European Journal of Organic Chemistry, EarlyView.
Beyond their established role in photoaffinity labeling, diazirines have emerged as versatile reagents in synthetic chemistry. This review highlights their dual reactivity as carbene and nitrogen‐transfer precursors, showcasing mechanistic insights and diverse applications in cyclopropanations, cycloadditions, skeletal editing, amination, heterocycle ...
Viktor Savic, Dominik Schnalzer, Marko D. Mihovilovic, Michael Schnürch   +3 more
wiley   +1 more source

From Disease Control to Long-Term Stability: Regenerative and Prosthetic Management of Peri-Implantitis-A Five-Year Case Report. [PDF]

Reports (MDPI)
Kwiatek J, Barczak O, Lenkowski M, Kaczewiak J, Tarnowski M.   +4 more
europepmc   +1 more source

Organic photonic synaptic transistors for bionic vision: From spectral engineering to flexible intelligent perception

FlexMat, EarlyView.
Different wavelength photonic synapses are used for biomimetic visual applications. Abstract Bionic intelligent visual perception systems have significant application prospects in fields such as autonomous driving and robotics, medical imaging and auxiliary diagnosis, security and monitoring.
Longlong Jiang, Shan Wu, Silu Feng, Heyi Huang, Wangyu Wu, Hong Han, Yao Ni   +6 more
wiley   +1 more source

Human Cellulosimicrobium Infections: A Clinically Oriented Review of Diagnostic and Therapeutic Challenges. [PDF]

Cureus
Benaissa E, Hnach N, Ben Lahlou Y, Chadli M.   +3 more
europepmc   +1 more source

Wide‐range and high‐resolution Young's modulus sensing enabled by a complementary indentation‐protrusion architecture

FlexMat, EarlyView.
A tactile sensor integrating indentation and protrusion sensing within a single platform enables accurate perception of object Young's modulus. This complementary architecture expands the detectable Young's modulus range to 25.8–2639.2 kPa and achieves an object recognition accuracy of 94.27%, outperforming indentation‐only (84.59%) and protrusion‐only
Jiasen Xie, Xingyu Ma, Yongming Wang, Ying Yang, Mingwei Gu, Lin Zheng, Junshuai Chen, Yunjie Lu, Jinhui Gu, Jin Ge   +9 more
wiley   +1 more source

Endocarditis in Adults with Congenital Heart Disease. [PDF]

Methodist Debakey Cardiovasc J
Busti A, Annoni G, Napoleone CP.
europepmc   +1 more source

Artificial structures for human‐machine interfaces with closed‐loop interaction

FlexMat, EarlyView.
Artificial structures bridge sensing and feedback in closed‐loop human‐machine interfaces by providing geometry‐enabled mechanical and functional programmability. This review maps the role of artificial structures in diverse sensing modalities and feedback strategies, and illustrates their integration into closed‐loop interaction systems, highlighting ...
Taiqi Hu, Taisong Pan, Siqi Chen, Yiting Zhang, Yuan Lin   +4 more
wiley   +1 more source