Results 111 to 120 of about 1,607,552 (384)

Protease inhibition as new therapeutic strategy for GI diseases

Gut, 2016
The GI tract is the most exposed organ to proteases, both in physiological and pathophysiological conditions. For digestive purposes, the lumen of the upper GI tract contains large amounts of pancreatic proteases, but studies have also demonstrated ...
N. Vergnolle
semanticscholar   +1 more source

Transcriptome‐wide analysis of circRNA and RBP profiles and their molecular relevance for GBM

Molecular Oncology, EarlyView.
CircRNAs are differentially expressed in glioblastoma primary tumors and might serve as therapeutic targets and diagnostic markers. The investigation of circRNA and RNA‐binding proteins (RBPs) interactions shows that distinct RBPs play a role in circRNA biogenesis and function.
Julia Latowska‐Łysiak, Żaneta Zarębska, Marcin P. Sajek, Adriana Grabowska, Alessia Buratin, Paweł Głodowicz, Julia O. Misiorek, Konrad Kuczyński, Stefania Bortoluzzi, Marek Żywicki, Jan G. Kosiński, Agnieszka Rybak‐Wolf, Rafał Piestrzeniewicz, Anna M. Barciszewska, Katarzyna Rolle   +14 more
wiley   +1 more source

Isolation and Molecular Characterization of Rummelii Bacillus Stabekisii: An Efficient Protease Producing Bacterial Strain Identified from Environmental Waste Samples of Warangal District in Telangana

Journal of Pure and Applied Microbiology, 2020
The exploration of novel sources of commercially important enzymes is important due to the enormous industrial requirement. Modern isolation, screening and characterization techniques expedited such efforts. Protease is a highly specific and one of the
Lapaka Suresh, Alpula Nagaraju, Ramya Chouhan, Srinivas Podeti   +3 more
doaj   +1 more source

Structure of the NS2B-NS3 protease from Zika virus after self-cleavage

Nature Communications, 2016
The recent outbreak of Zika virus (ZIKV) infections in the Americas represents a serious threat to the global public health. The viral protease that processes viral polyproteins during infection appears as an attractive drug target.
W. W. Phoo, Yan Li, Zhenzhen Zhang, Michelle Yueqi Lee, Y. R. Loh, Yaw Bia Tan, Elizabeth Yihui Ng, J. Lescar, C. Kang, D. Luo   +9 more
semanticscholar   +1 more source

Targeting the MDM2‐MDM4 interaction interface reveals an otherwise therapeutically active wild‐type p53 in colorectal cancer

Molecular Oncology, EarlyView.
This study investigates an alternative approach to reactivating the oncosuppressor p53 in cancer. A short peptide targeting the association of the two p53 inhibitors, MDM2 and MDM4, induces an otherwise therapeutically active p53 with unique features that promote cell death and potentially reduce toxicity towards proliferating nontumor cells.
Sonia Valentini, Giada Mele, Marika Attili, Maria Rita Assenza, Fulvio Saccoccia, Francesca Sardina, Cinzia Rinaldo, Roberto Massari, Nicola Tirelli, Alfredo Pontecorvi, Fabiola Moretti   +10 more
wiley   +1 more source

Identification of angiotensin I-converting enzyme inhibitory peptides from enzymatic hydrolysates of pork loin

International Journal of Food Properties, 2019
This study aimed to identify angiotensin I-converting enzyme (ACE) inhibitory peptides in enzymatic hydrolysates from pork loin. Pork hydrolysates were produced by injecting different enzymes to the loins as follows: un-injected pork (fresh pork ...
Juhui Choe, Kuk-Hwan Seol, Dong-In Son, Hyun Jung Lee, Mooha Lee, Cheorun Jo   +5 more
doaj   +1 more source

Influence of mild pulsed electric field conditions on the growth and protease activity of Streptococcus thermophilus

The Iraqi Journal of Veterinary Medicine, 2010
Pulsed electric field (PEF) processing involves the application of pulses of voltage for less than one second to fluid products placed between two electrodes.
Najim Hadi Najim
doaj   +1 more source

Lipometabolic side-effects of three ritonavir-boosted double protease inhibitor regimens without reverse transcriptase inhibitors [PDF]

, 2008
Poster presentation: Purpose of the study To compare the lipometabolic profiles of three double-boosted protease inhibitor (PI) regimens at standard dose, containing saquinavir and ritonavir in combination with lopinavir (LOPSAQ), atazanavir (ATSAQ) or ...
Bickel, Markus, Hentig, Nils von, Khaykin, Pavel, Knecht, Gaby, Lennemann, Tessa, Lutz, Thomas, Staszewski, Schlomo, Stephan, Christoph, Wendig, Annette   +8 more
core   +1 more source

A Genomic Analysis of Rat Proteases and Protease Inhibitors [PDF]

Genome Research, 2004
Proteases perform important roles in multiple biological and pathological processes. The availability of the rat genome sequence has facilitated the analysis of the complete protease repertoire or degradome of this model organism. The rat degradome consists of at least 626 proteases and homologs, which are distributed into 24 aspartic, 160 cysteine ...
Carlos López-Otín, Xose S. Puente
openaire   +3 more sources

HIV protease inhibitors: a review of molecular selectivity and toxicity

HIV/AIDS, 2015
Highly active antiretroviral therapy (HAART) is recognized as the most effective treatment method for AIDS, and protease inhibitors play a very important role in HAART. However, poor bioavailability and unbearable toxicity are their common disadvantages.
Zhengtong Lv, Y. Chu, Yong Wang
semanticscholar   +1 more source