Results 211 to 220 of about 930,417 (268)

Proteases and protease inhibitors in cancer

Acta Histochemica, 1998
The second conference on 'Proteases and protease inhibitors in cancer' was organized by the American Association for Cancer Research (AACR) and Acta Pathologica Microbiologica et Immunologica Scandinavica (APMIS). To understand the role of proteinases and to develop relevant synthetic inhibitors to stop or slow the progression of cancer, an integrated ...
openaire   +4 more sources

Engineering of proteases and protease inhibition

Current Opinion in Biotechnology, 1991
Proteases are unquestionably the single most studied class of enzymes and yet many questions still remain about their mechanisms and roles. Protein engineering offers the opportunity to provide some of the answers. In this review, recent advances towards the understanding of stability, mechanism, specificity and regulation of proteases and their ...
openaire   +2 more sources

Proteases and Protease Inhibitors in Tumor Progression

1997
Our understanding of the role of matrix degrading proteases in cancer has dramatically expanded over the last two decades. From correlative observations linking proteases to cancer progression, we have accumulated evidence supporting a causal role for proteases in various steps of tumor progression and have become increasingly aware of the complex ...
Y A, DeClerck, S, Imren, A M, Montgomery, B M, Mueller, R A, Reisfeld, W E, Laug   +5 more
openaire   +2 more sources

Inhibition of mite protease (Df-protease) with protease inhibitors.

Biochemistry international, 1993
A protease from house dust mite(Dermatophagoides farinae) having high specificity towards a substrate of blood coagulation factor XIIa catalyzes the activation of kallikrein-kinin system in plasma (Takahashi et al., 1990). To prevent the formation of kinin by the mite-protease, inhibition of the protease with its inhibitors was tested in vitro and in ...
A, Matsushima, Y, Kodera, S, Ozawa, M, Kobayashi, H, Maeda, Y, Inada   +5 more
openaire   +1 more source

Periplasmic Proteases and Protease Inhibitors

2014
In general, proteases are involved in diverse functions; the most notable include digestive, protective, and regulatory processes. Digestive proteases are involved in protein degradation for nutritional purposes. About 35% of all entries in the MEROPS database are classified as serine proteases.
Nicolette Kucz, Michael Meltzer, Michael Ehrmann   +2 more
openaire   +1 more source

Flaviviruses proteases

West Nile virus (WNV), Zika virus (ZIKV), and Dengue virus (DENV) are vector-borne diseases endemic in tropical and subtropical countries around the world. Their incidence has been growing in recent years and they are becoming increasingly relevant even in non-endemic areas, representing a significant public health problem worldwide.
Zammarchi, Lorenzo, Chechi, Flavia, Spinicci, Michele, Bartoloni, Alessandro   +3 more
openaire   +2 more sources

Protease or protease inhibitor?

Nature, 1990
T. SKERN, M. ZORN, D. BLAAS, E. KUECHLER, W. SOMMERGRUBER   +4 more
openaire   +1 more source

Potential Resistance of SARS-CoV-2 Main Protease (Mpro) against Protease Inhibitors: Lessons Learned from HIV-1 Protease

International Journal of Molecular Sciences, 2022
József Tozser, János András Mótyán, Mohamed Mahdi   +2 more
exaly  

The HIV-1 Viral Protease Is Activated during Assembly and Budding Prior to Particle Release

Journal of Virology, 2022
Najwa Alhusaini, Caroline Tabler, John Tilton   +2 more
exaly  

Effects of temperature and pH on the structure of a protease from Lactobacillus brevis R4 isolated from Harbin dry sausage and molecular docking of the protease to the meat proteins

Food Bioscience, 2021
Fangda Sun, Baohua Kong
exaly