Results 91 to 100 of about 333,858 (311)
Inhibition of dipeptidyl peptidase 7 impairs lysophagy in LLOMe‐treated HepG2 cells
FEBS Letters, EarlyView.DPP7 inhibition delays ubiquitin‐dependent lysophagy by attenuating ubiquitin accumulation and the recruitment of SQSTM1 and LC3 to damaged lysosomes, resulting in delayed clearance of damaged lysosomes and impaired restoration of lysosomal homeostasis. Created using FigureLabs (Certificate ID: FL‐PUB‐20260922‐Z99XNX).
Na Yeon Park +8 more
wiley +1 more source
DNA ligase LigE increases bacterial transformation with damaged extracellular DNA
FEBS Letters, EarlyView.The DNA ligase LigE from the naturally competent Gram‐negative bacterium Neisseria gonorrhoaea increases transformation with cut extracellular DNA. This process is ATP‐dependent and relies on the catalytic activity of LigE; it also requires that LigE contains an intact periplasmic localisation sequence, indicating that ligE functions in the periplasm ...
Jolyn Pan +4 more
wiley +1 more source
Proteases in Vibrio cholerae and Their Role in Pathogenesis
, 2013 Hemagglutinin protease (HAP) produced by Vibrio cholerae is the most well characterized protease in pathogenic Vibrio. The matured 45-kDa and 35-kDa processed forms of HAP were purified from a ctx gene negative Vibrio cholerae O1 strain.
Amit Pal +3 more
core +1 more source
Papain-like proteases: Applications of their inhibitors [PDF]
, 2010 Proteases are one of the most important classes of enzyme and expressed throughout the animal and plant kingdoms as well as in viruses and bacteria.
Pande, M +3 more
core +1 more source
Comparing the paths of Hedgehog release in artificial and natural settings
FEBS Letters, EarlyView.Hh morphogens require solubilization factors to overcome their tight association with the plasma membrane and signal to distant cells, but the precise functions of these factors are controversial. Here, we use published in vivo observations as the most relevant evidence to test their suggested functions and discuss contradictions and gaps between in ...
Janna Puschmann, Kay Grobe
wiley +1 more source
Molecular and biochemical characterization of subtilisin-like proteases in arabidopsis thaliana [PDF]
, 2000 Subtilisin-like proteases form a large group of serine proteases with diverse functions, including the specific processing of a variety of proproteins and prohormones, and are found in prokaryotic and eukaryotic organisms. The work in this thesis focuses
Hamilton, John Michael Uwe
core
Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment
Molecular Oncology, EarlyView.This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley +1 more source
ATP-dependent proteases in the chloroplast
, 2008 Systematic comparative analysis of the available sequenced genomes of model organisms has led to the identification of an increasing number of protease genes.
Pružinská, Adriana, +2 more
core
Molecular Oncology, EarlyView.Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla +9 more
wiley +1 more source
Novel proteases and uses thereof
, 2022 The present invention relates to novel proteases, more particularly to protease variants having improved thermostability compared to the protease of SEQ ID N°1 and the uses thereof for degrading polyester containing material, such as plastic products ...
André, Isabelle +3 more
core +1 more source