Results 201 to 210 of about 333,858 (311)

Trypsin is as procoagulant as factor XIIa. [PDF]

Bleeding Thromb Vasc Biol
Smith SA, Morrissey JH.
europepmc   +1 more source

An Antimicrobial, Cell‐Adhesive, and Growth Factor‐Producing Living Material Engineered From Bacillus subtilis Biofilms for Wound Healing

Advanced Healthcare Materials, EarlyView.
Bacillus subtilis is engineered to produce cell‐adhesive biofilms by functionalization of its biofilm scaffold protein TasA with a cell‐adhesion sequence. Living bacteria within the biofilm are also engineered to secrete growth factors and natively produce antimicrobial peptides (AMPs), resulting in a cell‐adhesive, antimicrobial, and growth factor ...
Mélanie Côté‐Cyr, Marie‐Jeanne Archambault, Caroline Dupuis, Steve Bourgault   +3 more
wiley   +1 more source

The expanding role of protease therapeutics (2012-2026): from replacement therapies to immune system modulation and beyond. [PDF]

Biochem J
Nelson SE, Martinusen SG, Pho R, Long LF, Denard CA.   +4 more
europepmc   +1 more source

Measuring Blood Plasma Glutamine Levels Using a Nanopore‐Based Sensor

Advanced Healthcare Materials, EarlyView.
Glutamine (GLN) is a biomarker useful for predicting toxic ammonia accumulation. Here, we used a biosensor based on the Cytolysin A (ClyA) nanopore coupled with the GLN‐specific protein substrate‐binding domain 2 (SBD2) to demonstrate real‐time measurement of GLN in blood plasma, highlighting the potential for future point‐of‐care applications ...
Sofia B. Relvas, Iris M. Kormelink, Sandra Michel‐Souzy, Florian L. R. Lucas, Nieck J. van der Heide, Hans R. Waterham, Ramon Versteeg, Judith Jans, Loes I. Segerink, Carsten Wloka   +9 more
wiley   +1 more source

The Role of Viscoelasticity in Heterogeneous Glioblastoma Stem Cell Invasion in Biomimetic 3‐Dimensional Hydrogels

Advanced Healthcare Materials, EarlyView.
The role of viscoelasticity in the invasion of heterogeneous glioblastoma stem cells (GSCs) was investigated with GSCs categorized into subgroups based on molecular profile, as Reactive, Invasive, or Constructive using viscoelastic biomimetic hyaluronan‐oxime hydrogels.
Nicole J. Blaine, Arianna Skirzynska, Allysia A. Chin, Julie Audet, Molly S. Shoichet   +4 more
wiley   +1 more source

An integrated proteomics and transcriptomics analysis highlights concordance between protein turnover and carbohydrate transport and metabolism as key functional categories during the growth of <i>Trichophyton rubrum</i>. [PDF]

Microbiol Spectr
Singh H, Latka C, Chakraborty R, Dhingra L, Bhalla S, Taneja B.   +5 more
europepmc   +1 more source

Modeling Early Metastatic Progression in Breast Cancer Using a Barrier‐Free, Perfusable Spheroid‐on‐a‐Chip Platform

Advanced Healthcare Materials, EarlyView.
Open‐port, barrier‐free microfluidic device for modeling early metastatic progression. A centrally positioned tumor spheroid releases invasive cells that migrate through the surrounding matrix and intravasate into endothelialized lateral channels.
Vira Sharko, Claudia Olaizola‐Rodrigo, Clara Bayona, Teodora Ranđelović, Rosa Monge, Estela Solanas, Sara Oliván, Ignacio Ochoa   +7 more
wiley   +1 more source

Enzymatic Degradation of <i>Cryptosporidium</i> spp. Oocysts: A Combined In Silico and In Vitro Study. [PDF]

Molecules
Souza DCT, Silva AC, Silva ATBD, Mamani RCC, Jorge JGC, Ferraz CM, Braga FR, Araújo JV, Soares FEF.   +8 more
europepmc   +1 more source

Advanced Materials for Biologics Delivery to Brain Tumors

Advanced Materials, EarlyView.
Material innovation is central to unlocking the therapeutic potential of biologics against many central nervous system diseases, including brain cancer. By engineering carriers with controlled transport, targeting, and release properties, advanced materials can overcome the blood–brain barrier and tumor microenvironment, improving the delivery of ...
Yuran Feng, Yuxue Cao, Maria Kavallaris, Taskeen Janjua, Amirali Popat   +4 more
wiley   +1 more source