Results 241 to 250 of about 333,858 (311)

Linker Design in Antibody-Drug Conjugates: Balancing Stability and Drug Release. [PDF]

open access: yesPharmaceutics
Albino SN   +5 more
europepmc   +1 more source

Plant Proteases: From Phenotypes to Molecular Mechanisms [PDF]

open access: yesAnnual Review of Plant Biology, 2008
Plant genomes encode hundreds of proteases, which represent dozens of unrelated families. The biological role of these proteases is mostly unknown, but mutant alleles, gene silencing, and overexpression studies have provided phenotypes for a growing ...
Renier van der Hoorn
exaly   +2 more sources
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Proteases, proteases and proteases for presentation

Nature Immunology, 2003
Peptide epitope generation for MHC class I presentation is normally dependent upon proteasome activity. Yet this pathway fails to generate critical HIV epitopes. Instead, the protease TPPII is required for this activity.
Herberts, Carla   +2 more
openaire   +2 more sources

Proteases, protease inhibitors and radiation carcinogenesis

International Journal of Radiation Biology, 2021
The purpose of the studies described in this mini review article was to identify nontoxic compounds that could prevent or suppress the radiation induced malignant transformation of cells and be useful as human cancer preventive agents.(1) Many different types of potential anticarcinogenic substances were evaluated initially for their abilities to ...
openaire   +2 more sources

Proteases and protease inhibitors in infectious diseases

Medicinal Research Reviews, 2017
AbstractThere are numerous proteases of pathogenic organisms that are currently targeted for therapeutic intervention along with many that are seen as potential drug targets. This review discusses the chemical and biological makeup of some key druggable proteases expressed by the five major classes of disease causing agents, namely bacteria, viruses ...
Ayodeji A. Agbowuro   +3 more
openaire   +2 more sources

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