Results 351 to 360 of about 771,571 (414)

Characteristics and immunoprotective functions of three cysteine proteases from <i>Clonorchis sinensis</i>. [PDF]

Front Immunol
Shi Y, Li X, Liang K, Lu T, Chen Y, Lai Y, Li Y, Wei S, He S, Tang L, Liu D, Li Y.   +11 more
europepmc   +1 more source

The Reconstruction of Peripheral Auditory Circuit: Recent Advances and Future Challenges

Advanced Science, EarlyView.
This paper summarizes the potential of biomaterials, stem cells, and gene editing technologies in the regeneration of inner ear hair cells, spiral ganglion neurons, and inner ear organoids. Challenges and potential developments are discussed and explored.
Zhe Li, Ying Zhang, Zhenyu Xiao, Jieyu Qi   +3 more
wiley   +1 more source

Staphylococcal SplA and SplB serine proteases target ubiquitin(-like) specific proteases. [PDF]

AMB Express
Glinka FL, Schmöker O, Singh AK, Steil L, Hentschker C, Völker U, Böttcher D, Lammers M, Cammann C, Seifert U, Krüger E, Naumann M, Bröker BM, Bornscheuer UT.   +13 more
europepmc   +1 more source

Conjugated Lithocholic Acid Activates Hepatic TGR5 to Promote Lipotoxicity and MASLD‐MASH Transition by Disrupting Carnitine Biosynthesis

Advanced Science, EarlyView.
Takeda G protein‐coupled receptor 5 (TGR5) serves as a central regulator in the metabolic dysfunction‐associated steatotic liver disease (MASLD)/metabolic dysfunction‐associated steatohepatitis (MASH) transition via conjugated lithocholic acid (LCA). Mechanistically, TGR5 orchestrates lipotoxicity‐induced cell death through its interaction with CD36 ...
Senlin Lian, Meixi Lu, Luo Jiajing, Bin Zhang, Yi Fang, Xuran Wang, Minghua Zheng, Yan Ni, Guifang Xu, Yonglin Yang, Runqiu Jiang   +10 more
wiley   +1 more source

Substrate recognition and cleavage-site preferences of Lon protease. [PDF]

J Biol Chem
Cragan M, Puri N, Karzai AW.
europepmc   +1 more source

Targeting Replication Fork Processing Synergizes with PARP Inhibition to Potentiate Lethality in Homologous Recombination Proficient Ovarian Cancers

Advanced Science, EarlyView.
This study demonstrates that the resveratrol analogue, trans‐4,4′‐dihydroxystilbene (DHS), exhibits synergistic anti‐tumor activity with the PARP inhibitor talazoparib, inducing significant ovarian cancer cell death. The synergistic effect of this combination arises from the concurrent downregulation of homologous recombination factors and the ...
Ganesh Pai Bellare, Kshama Kundu, Papiya Dey, Krupa Thankam Philip, Nitish Chauhan, Muskan Sharma, Sankarsingh Kesharsingh Rajput, Birija Sankar Patro   +7 more
wiley   +1 more source

Meta-analysis of RNA-Seq datasets allows a better understanding of P. tricornutum cellular biology, a requirement to improve the production of Biologics. [PDF]

Sci Rep
Boulogne I, Toustou C, Bardor M.
europepmc   +1 more source

N-terminomics profiling of host proteins targeted by excretory-secretory proteases of the nematode Angiostrongylus vasorum identifies points of interaction with canine coagulation and complement cascade. [PDF]

PLoS One
Germitsch N, Kockmann T, Schnyder M, Tritten L.   +3 more
europepmc   +1 more source

NS2B-D55E and NS2B-E65D Variations Are Responsible for Differences in NS2B-NS3 Protease Activities Between Japanese Encephalitis Virus Genotype I and III in Fluorogenic Peptide Model. [PDF]

Int J Mol Sci
Wahaab A, Zhang Y, Liu K, Rasgon JL, Kang L, Hameed M, Li C, Anwar MN, Zhang Y, Shoaib A, Li B, Qiu Y, Wei J, Ma Z.   +13 more
europepmc   +1 more source

The antiprotease Spink7 promotes inflammation resolution by modulating multiple proteases activities during wound healing. [PDF]

Clin Transl Med
Zhao N, Wang G, Long S, Lv X, Ran X, Wang J, Su Y, Wang T.   +7 more
europepmc   +1 more source