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Non-classical neutrophil extracellular traps induced by PAR2-signaling proteases. [PDF]
Cell Death DisBryzek D +13 more
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Proteases and protease inhibitors in infectious diseases
Medicinal Research Reviews, 2017AbstractThere are numerous proteases of pathogenic organisms that are currently targeted for therapeutic intervention along with many that are seen as potential drug targets. This review discusses the chemical and biological makeup of some key druggable proteases expressed by the five major classes of disease causing agents, namely bacteria, viruses ...
Ayodeji A. Agbowuro +3 more
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Proteases, proteases and proteases for presentation
Nature Immunology, 2003Peptide epitope generation for MHC class I presentation is normally dependent upon proteasome activity. Yet this pathway fails to generate critical HIV epitopes. Instead, the protease TPPII is required for this activity.
Eric Reits +2 more
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Biochimica et Biophysica Acta (BBA) - Proteins and Proteomics, 2012
Autophagy is a process involved in the proteolytic degradation of cellular macromolecules in lysosomes, which requires the activity of proteases, enzymes that hydrolyse peptide bonds and play a critical role in the initiation and execution of autophagy. Importantly, proteases also inhibit autophagy in certain cases.
Boris Zhivotovsky, Vitaliy O. Kaminskyy
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Autophagy is a process involved in the proteolytic degradation of cellular macromolecules in lysosomes, which requires the activity of proteases, enzymes that hydrolyse peptide bonds and play a critical role in the initiation and execution of autophagy. Importantly, proteases also inhibit autophagy in certain cases.
Boris Zhivotovsky, Vitaliy O. Kaminskyy
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Proteases, protease inhibitors and radiation carcinogenesis
International Journal of Radiation Biology, 2021The purpose of the studies described in this mini review article was to identify nontoxic compounds that could prevent or suppress the radiation induced malignant transformation of cells and be useful as human cancer preventive agents.(1) Many different types of potential anticarcinogenic substances were evaluated initially for their abilities to ...
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Engineering of proteases and protease inhibition
Current Opinion in Biotechnology, 1991Proteases are unquestionably the single most studied class of enzymes and yet many questions still remain about their mechanisms and roles. Protein engineering offers the opportunity to provide some of the answers. In this review, recent advances towards the understanding of stability, mechanism, specificity and regulation of proteases and their ...
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