Results 331 to 340 of about 411,261 (379)

From Fibrosis to Malignancy: Mechanistic Intersections Driving Lung Cancer Progression. [PDF]

Cancers (Basel)
Chen B, Hamdy H, Zhang X, Cao P, Fu Y, Shen J.   +5 more
europepmc   +1 more source

HUWE1 in Skeletal Muscle Prevents Muscle Fatigue via Maintaining Iron and Calcium Homeostasis

Advanced Science, EarlyView.
This study investigates the impact of iron homeostasis on exercise. Loss of the HECT domain‐containing ubiquitin ligase E3 (HUWE1) in skeletal muscle restrains the exercise performance in mice with downregulated ferroportin expression leading to iron overload, which is ameliorated by dietary iron restriction.
Huike Jiao, Yuting Du, Danxia Zhou, Meng Bai, Xu Gao, Zhenyue Hao, Nan‐Jie Xu, Jiaqiang Liu, Ying Huang, Zhenji Gan, Jing Zhang   +10 more
wiley   +1 more source

Proteasome Subunits Regulate Reproduction in <i>Nilaparvata lugens</i> and the Transovarial Transmission of Its Yeast-like Symbionts. [PDF]

Insects
Lv X, Tu JY, Liu Q, Wu ZQ, Lin C, Zhou T, Yu XP, Xu YP.   +7 more
europepmc   +1 more source

Integrin β3 Orchestrates Hepatic Steatosis via a Novel CD36‐Dependent Lipid Uptake Complex

Advanced Science, EarlyView.
In MASH, ITGB3 recruits LYN and drives its ubiquitin‐proteasomal degradation via phosphorylation. This relieves DHHC5 inhibition, enabling ITGB3/DHHC5/CD36 complex assembly to enhance CD36 palmitoylation and fatty acid uptake, thereby exacerbating disease. Targeting ITGB3 blocks this pathogenic axis and ameliorates MASH.
Ying Zhang, Lei Dai, Zhongquan Cui, Ye Zhou, Wenyuan Dong, Hongcheng Jiang, Mengwen Wang, Xiaodan Zhong, Wei Dong, Zhang Yue, Thati Madhusudhan, Hongjie Wang, Xiong Zhong Ruan, Hesong Zeng   +13 more
wiley   +1 more source

Proteasome-driven modulation of immune and oxidative pathways during scorpion envenomation pathogenesis. [PDF]

J Venom Anim Toxins Incl Trop Dis
Megdad-Lamraoui A, Adi-Bessalem S, Daachi F, Laraba-Djebari F.   +3 more
europepmc   +1 more source

Regulation of Monocyte Perilipin-2 Expression in Acute and Chronic Coronary Syndromes: Pathogenetic Implications. [PDF]

Int J Mol Sci
Canonico F, Laborante R, Pidone C, Vinci R, Galli M, Pisano E, Bonanni A, Di Sario M, Severino A, Lisi L, Pedicino D, Liuzzo G, Ruscica M, Crea F, Patti G, D'Amario D.   +15 more
europepmc   +1 more source

Activin A Secreted by Cancer-Associated Fibroblasts Reduces the Sensitivity of Breast Cancer Cells to Ixazomib via Inhibition of Proteasome Activity. [PDF]

Biomolecules
Geng S, Liu S, Liu H, Wang S, Niu Y, Gao J, Meng Y, Gao M.   +7 more
europepmc   +1 more source

Autophagy and proteasomes in thymic epithelial cells: essential bulk protein degradation systems for immune homeostasis maintenance

Noritaka Yamaguchi, Yuki Takakura, Taishin Akiyama   +2 more
openalex   +1 more source

Immunoproteasome inhibition triggers protein stress and apoptosis in cells of B cell lineage without impairing vaccination-induced antibody responses. [PDF]

Cell Death Discov
Mink D, Oliveri F, Otto J, Kutsi N, Gonzalez Siebold C, Muchamuel T, Li J, Basler M.   +7 more
europepmc   +1 more source

Investigating NFE2L1 activators for targeted protein aggregate clearance: a follow-up study. [PDF]

RSC Med Chem
Smahelova Z, Svobodova L, Sedlacek J, Adamek M, Pimkova Polidarova M, Majer P, Machara A, Saskova KG.   +7 more
europepmc   +1 more source