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Modulation of CREB3L2-ATF4 heterodimerization via proteasome inhibition and HRI activation in Alzheimer's disease pathology. [PDF]

open access: yesCell Death Dis
Herline-Killian K   +7 more
europepmc   +1 more source

The Role of the Ubiquitin System in Eye Diseases. [PDF]

open access: yesLife (Basel)
Durán-Cristiano SC   +3 more
europepmc   +1 more source

Structural basis for the ubiquitin chain recognition of the human 26S proteasome

open access: yes
Amann SJ   +9 more
europepmc   +1 more source
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The proteasome and proteasome inhibitors in multiple myeloma

Cancer and Metastasis Reviews, 2017
Proteasome inhibitors are one of the most important classes of agents to have emerged for the treatment of multiple myeloma in the past two decades, and now form one of the backbones of treatment. Three agents in this class have been approved by the United States Food and Drug Administration-the first-in-class compound bortezomib, the second-generation
S. Gandolfi   +5 more
semanticscholar   +3 more sources

The ubiquitin‐proteasome pathway and proteasome inhibitors [PDF]

open access: yesMedicinal Research Reviews, 2001
AbstractThe ubiquitin‐proteasome pathway has emerged as a central player in the regulation of several diverse cellular processes. Here, we describe the important components of this complex biochemical machinery as well as several important cellular substrates targeted by this pathway and examples of human diseases resulting from defects in various ...
Craig M Crews, Kyung Bo Kim
exaly   +5 more sources

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