Results 51 to 60 of about 288,302 (311)

Organizing the interface—Plasma membrane architecture and receptor dynamics in virus‐cell interactions

open access: yesFEBS Letters, EarlyView.
Plasma membranes contain dynamic nanoscale domains that organize lipids and receptors. Because viruses operate at similar scales, this architecture shapes early infection steps, including attachment, receptor engagement, and entry. Using influenza A virus and HIV‐1 as examples, we highlight how receptor nanoclusters, multivalent glycan interactions ...
Jan Schlegel, Christian Sieben
wiley   +1 more source

Quality of marine protected areas is critical to achieving global biodiversity targets

open access: yesnpj Ocean Sustainability
Summarising CBD target 3 to “30 × 30” emphasizes area coverage, but conservation success depends on MPA quality. Many existing MPAs are under-protected, and rapidly designating new areas risks creating ‘paper parks’ without ecological or social benefits.
Fabrice Stephenson   +22 more
doaj   +1 more source

Comportamento produtivo e econômico da alface americana em função de diferentes lâminas de água Economic and productive behavior of production of crisphead lettuce under different irrigation depths

open access: yesRevista Brasileira de Engenharia Agrícola e Ambiental, 2011
Visando às dificuldades encontradas pelo produtor no cultivo da alface (Lactuta sativa L.) americana, cv. Laureau, especificamente quanto à falta de informações técnicas sobre quantidade de água a aplicar, objetivou-se estudar o efeito de diferentes ...
Joaquim A. de Lima Júnior   +5 more
doaj   +1 more source

Transcriptional network analysis of PTEN‐protein‐deficient prostate tumors reveals robust stromal reprogramming and signs of senescent paracrine communication

open access: yesMolecular Oncology, EarlyView.
Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice   +16 more
wiley   +1 more source

Potential therapeutic targeting of BKCa channels in glioblastoma treatment

open access: yesMolecular Oncology, EarlyView.
This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak   +4 more
wiley   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

open access: yesMolecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Circular RNA expression landscapes in myelodysplastic neoplasms: Associations with mutational signatures and disease progression

open access: yesMolecular Oncology, EarlyView.
In this explorative study, the abundance of circular RNA molecules in bone marrow stem cells was found to be elevated in patients with high‐risk myelodysplastic neoplasms, and to be associated with an increased risk of progression to acute myeloid leukemia.
Eileen Wedge   +17 more
wiley   +1 more source

Study on Multiscale Virtual Environment Construction and Spatial Navigation Based on Hierarchical Structure

open access: yesISPRS International Journal of Geo-Information
Multiscale virtual environments (MSVEs) allow the integration of elements and environments at different scale levels into a unified space, which facilitates researchers’ perception, understanding, and experimental research of complex geospatial spaces ...
Chao Chen   +5 more
doaj   +1 more source

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