Results 51 to 60 of about 327,704 (298)

Tau acetylation at K331 has limited impact on tau pathology in vivo

FEBS Letters, EarlyView.
We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto, Yukio Matsuba, Mika Takahashi, Takaomi C. Saido   +3 more
wiley   +1 more source

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

FEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa, Konstantinos Makryniotis, Theofani‐Iosifina Sousani, Evangelos Topakas, Vangelis Daskalakis, Maria Dimarogona   +5 more
wiley   +1 more source

Diversity and complexity in neural organoids

FEBS Letters, EarlyView.
Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley   +1 more source

Investigating Protected Health Information Privacy: Smart City Policymaker Challenges

, 2023
Smart Cities are characterized as urban information and communication technology hubs focused on renovating community healthcare ecosystems. Expanded smartphones, tablets, and internet of things (IoT) use have increased fears about digital healthcare ...
Dailey, Marcia, Wilkerson, John, Brown, Paul   +2 more
core   +2 more sources

Organizing the interface—Plasma membrane architecture and receptor dynamics in virus‐cell interactions

FEBS Letters, EarlyView.
Plasma membranes contain dynamic nanoscale domains that organize lipids and receptors. Because viruses operate at similar scales, this architecture shapes early infection steps, including attachment, receptor engagement, and entry. Using influenza A virus and HIV‐1 as examples, we highlight how receptor nanoclusters, multivalent glycan interactions ...
Jan Schlegel, Christian Sieben
wiley   +1 more source

The Sexual health of pupils in years 4 to 6 of primary schools in rural Tanzania [PDF]

, 2003
Background/objectives: There is an urgent need for effective interventions to improve the sexual and\ud reproductive health of adolescents. Reliable data on the sexual health of adolescents are needed to guide\ud the development of such interventions ...
Mabey, D.C.W., Mabey, DCW, Balira, R, Obasi, A.I.N, Changalucha, J, Obasi, AIN, Ross, DA, Ross, D.A., Plummer, M, Grosskurth, H, Mosha, F, Todd, J, Hayes, R   +12 more
core   +1 more source

How NFTs could transform health information exchange

, 2022
Personal (sometimes called “protected”) health information (PHI) is highly valued (1) and will become centrally important as big data and machine learning move to the forefront of health care and translational research.
Cohen, Glenn, Kostick-Quenet, Kristin, Mandl, Kenneth D., Gasser, Urs, McGuire, Amy L., Minssen, Timo, Kohane, Isaac   +6 more
core   +1 more source

Sexual behavior among Brazilian adolescents, National Adolescent School-based Health Survey (PeNSE 2012)

Revista Brasileira de Epidemiologia, 2014
OBJECTIVE: This study describes the sexual behavior among students who participated in the National Adolescent School-based Health Survey (PeNSE) 2012 and investigates whether social inequalities, the use of psychoactive substances and the dissemination
Maryane Oliveira-Campos, Marília Lavocart Nunes, Fátima de Carvalho Madeira, Maria Goreth Santos, Silvia Reise Bregmann, Deborah Carvalho Malta, Luana Giatti, Sandhi Maria Barreto   +7 more
doaj   +1 more source

Proportion of births protected against neonatal tetanus and its associated factors among mothers who gave birth within the past 6 months in Gozamn district, Northwest Ethiopia, 2022

Human Vaccines & Immunotherapeutics, 2023
Today, neonatal tetanus accounts for a significant portion of newborn and under−5 mortality – 40% and 57%, respectively – and is the most prevalent cause of neonatal mortality and morbidity, particularly in developing nations.
Anteneh Gashaw, Melaku Hunie, Eyuel Amare, Amare Zewdie, Mesfin Abebe, Muluken Demeke, Samuel Kefelegn, Daniel Yehualashet, Asrat Alemu, Yayeh Adamu, Tesfaye Gugsa, Anmut Tagele   +11 more
doaj   +1 more source

An unexpected alternative viologen electron mediator site in tungsten‐containing formate dehydrogenase

FEBS Letters, EarlyView.
An unexpected alternative interaction site for ethyl viologen was identified in formate dehydrogenase 1 from Methylorubrum extorquens. Combined mutagenesis, kinetic analysis, and docking revealed that aromatic residues near an iron–sulfur cluster enable flavin mononucleotide‐independent electron transfer, offering a framework for engineering improved ...
Eleni G. Poloniataki, Yong Hwan Kim
wiley   +1 more source