Results 31 to 40 of about 195,911 (265)

From mice to humans—divergent strategies for intestinal homeostasis and regeneration

FEBS Letters, EarlyView.
Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa, Shinya Sugimoto, Toshiro Sato   +2 more
wiley   +1 more source

Bone density and genomic analysis unfold cold adaptation mechanisms of ancient inhabitants of Tierra del Fuego

Scientific Reports, 2021
The Fuegians, ancient inhabitants of Tierra del Fuego, are an exemplary case of a cold-adapted population, since they were capable of living in extreme climatic conditions without any adequate clothing.
Mikiko Watanabe, Renata Risi, Mary Anne Tafuri, Valentina Silvestri, Daniel D’Andrea, Domenico Raimondo, Sandra Rea, Fabio Di Vincenzo, Antonio Profico, Dario Tuccinardi, Rosa Sciuto, Sabrina Basciani, Stefania Mariani, Carla Lubrano, Saverio Cinti, Laura Ottini, Giorgio Manzi, Lucio Gnessi   +17 more
doaj   +1 more source

Three phosphatase families form a community: The phosphohydrolases that act upon inositol pyrophosphates

FEBS Letters, EarlyView.
Inositol pyrophosphates are energy‐rich signaling molecules that perform critical functions in cells. Three different families of phosphatases hydrolyze the β phosphate of the inositol pyrophosphate molecules: two have narrow specificities and one is promiscuous.
Ronda J. Rolfes
wiley   +1 more source

Yakut clothes of the 17th and 18th centuries, archaeology and restitution [PDF]

Вестник археологии, антропологии и этнографии, 2020
40 frozen yakutian graves, from the 17th to the 19th century allow the reconstitution of clothes. At the end of the 17th century, new fashions are emerging with the ostentatious use of imported goods and the influences of Russian noble circles and ...
Hochstrasser-Petit Ch. , Romanova L. , Duchesne S. , Melnichuk O. , Gérard P.   +4 more
doaj   +1 more source

Cold Gas Spraying of Nickel-Titanium Coatings for Protection Against Cavitation [PDF]

Journal of Thermal Spray Technology, 2020
AbstractCavitation erosion is a sever wear mechanism that takes place in hydrodynamic systems. Examples are turbine vanes of hydropower plants or components of valves and pumps in hydraulic systems. Nickel-titanium shape memory alloys (NiTi) are attractive materials for cavitation-resistant coatings because of their pronounced intrinsic damping ...
Mauer, Georg, Rauwald, Karl-Heinz, Sohn, Yoo Jung, Weirich, Thomas E.   +3 more
openaire   +4 more sources

An epithelial GPR35 isoform supports tumor‐associated transcriptional and metabolic phenotypes

FEBS Letters, EarlyView.
GPR35 generates two functionally distinct isoforms with previously unresolved roles. GPR35‐short mediates immune‐cell chemotaxis, while GPR35‐long is enriched in colorectal cancer epithelium, where it supports increased metabolism, proliferation, and tumor‐associated transcriptional programs.
Jørgen D. Rønneberg, Martine Hjeltnes, Josephine Krieger, Joshua E. Elias, Maria Stensland, Kristian Holm, Xiaojun Jiang, Chuki Khangsar, Tuula A. Nyman, Arthur Kaser, Johannes R. Hov, Tom H. Karlsen, Nicole C. Kaneider, Frode L. Jahnsen, Georg Schneditz   +14 more
wiley   +1 more source

Dimethyl fumarate combined with cisplatin at subcytotoxic doses sensitizes cervical cancer toward ferroptosis and apoptosis through GSH restriction and p53 (re)activation

Molecular Oncology, EarlyView.
Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano, Giuseppina Minopoli, Simona Romano, Laura Marrone, Katia Aquilano, Maria Lina Tornesello, Raffaella Faraonio   +6 more
wiley   +1 more source

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

Mitochondria as a target and central hub of energy division during cold stress in insects

Frontiers in Zoology, 2022
Temperature stress is one of the crucial factors determining geographical distribution of insect species. Most of them are active in moderate temperatures, however some are capable of surviving in extremely high as well as low temperatures, including ...
Jan Lubawy, Szymon Chowański, Zbigniew Adamski, Małgorzata Słocińska   +3 more
doaj   +1 more source

Cold related mortalities and protection against cold in Yakutsk, eastern Siberia: observation and interview study [PDF]

BMJ, 1998
Abstract Objective: To assess how effectively measures adopted in extreme cold in Yakutsk control winter mortality. Design: Interviews to assess outdoor clothing and measure indoor temperatures; regressions of these ...
G C, Donaldson, S P, Ermakov, Y M, Komarov, C P, McDonald, W R, Keatinge   +4 more
openaire   +2 more sources