Results 81 to 90 of about 812,314 (361)

Holistic and leadership approaches to international regulation: confronting nature conservation and developmental challenges. A response to Farnese [PDF]

, 2014
International nature protection law has developed without a coherent plan, with disparate governance instruments each largely evolving within their own separate sphere.
Charnovitz, Robin, Stephenson
core   +1 more source

Genetic attenuation of ALDH1A1 increases metastatic potential and aggressiveness in colorectal cancer

Molecular Oncology, EarlyView.
Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova, Zuzana Kozovska, Ondrej Pos, Kristina Pavlov, Sachin Gulati, Peter Makovicky, Kristina Jakic, Monika Burikova, Eva Sedlackova, Barbora Svitkova, Silvia Tyciakova, Vojtech Bystry, Nicolas Blavet, Boris Tichy, Matej Hrnciar, Jaroslav Budis, Miroslav Tomas, Peter Dubovan, Georgina Kolnikova, Veronika Repaska, Nikoleta Mojzesova, Eva Zomborska, Daniel Pindak, Michal Mego, Tomas Szemes, Miroslava Matuskova   +25 more
wiley   +1 more source

Labour Market Institutions and the Employment Intensity of Output Growth. An International Comparison [PDF]

This paper deals with the effects of labour market institutions on labour market performance. We analyse as an indicator for the labour intensity of output growth the employment threshold (the minimum growth rate of output necessary to keep employment ...
Gebhard Flaig, Horst Rottmann
core  

Network divergence analysis identifies adaptive gene modules and two orthogonal vulnerability axes in pancreatic cancer

Molecular Oncology, EarlyView.
Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson, Lyanne Delgado‐Coka, Natalia Marchenko, Luisa F. Escobar‐Hoyos, Kenneth R. Shroyer, Alisa Yurovsky, Trey Ideker, Gábor Balázsi, Thomas MacCarthy, Scott Powers   +9 more
wiley   +1 more source

Finding Optimal Zone II Settings for Distance Relays in Coordination With Directional Overcurrent Relays Using QCQP Algorithm

IEEE Access
This paper introduces a deterministic method to address coordination challenges between distance relays (DS) and directional overcurrent relays (DOR) by employing quadratic programming with quadratic constraints (QCQP).
N. Praneeth, S. T. P. Srinivas, Alivelu M. Parimi, J. Ankamma Rao, Getie Tesfaye Zelie   +4 more
doaj   +1 more source

Inter-trip links incorporated optimal protection coordination

International Journal of Electrical and Computer Engineering (IJECE), 2020
Due to advances in smart grid, different communication links as delay, inter-trip and activation are used between relays to enhance the protection system performance. In this paper, the effect of inter-trip links on optimal coordination of directional overcurrent relays (DOCRs) is analytically investigated and modelled.
Ali Abbasi, Hossein Kazemi Karegar, Tohid Soleymani Aghdam   +2 more
openaire   +2 more sources

COMP–PMEPA1 axis promotes epithelial‐to‐mesenchymal transition in breast cancer cells

Molecular Oncology, EarlyView.
This study reveals that cartilage oligomeric matrix protein (COMP) promotes epithelial‐to‐mesenchymal transition (EMT) in breast cancer. We identify PMEPA1 (protein TMEPAI) as a novel COMP‐binding partner that mediates EMT via binding to the TSP domains of COMP, establishing the COMP–PMEPA1 axis as a key EMT driver in breast cancer.
Konstantinos S. Papadakos, Gilar Gorji‐bahri, Lejla Gradjan, Julia Zajac, Kacper Gil, Yvonne Thokozile Nduku, Anna M. Blom   +6 more
wiley   +1 more source

The development of performance, interference, sharing and coordination criteria [PDF]

The criteria for sharing and coordination between the Earth Exploration Satellite service and other radio services is not fully developed at this time. The purpose is to develop a plan showing how the necessary criteria might be developed.
Tillotson, Tom
core   +1 more source

Europe and the Unitary Patent: Progress Towards Reshaping the European Patent Landscape [PDF]

, 2012
It is surprising that the European Union has failed to create a Unitary Patent which would fully liberalise the flow of ideas as the single market facilitated the flow of capital and people.
Global Policy Institute, Radcliffe, Bertie   +1 more
core  

Engineered extracellular vesicles enriched with the miR‐214/199a cluster enhance the efficacy of chemotherapy in ovarian cancer

Molecular Oncology, EarlyView.
Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang, Ayesha Alvero, Yi Qin, Mingjin Wang, Alexandra Fox, Yanfeng Li, Michael Millman, Amy Kemper, Gil Mor, Xian Shuang Liu, Michael Chopp, Zheng Gang Zhang, Yi Zhang   +12 more
wiley   +1 more source