Results 81 to 90 of about 3,147,413 (303)

Investor Protection and Equity Markets [PDF]

open access: yes
We present a simple model of an entrepreneur going public in an environment with poor legal protection of outside shareholders. The model incorporates elements of Becker's (1968) crime and punishment' framework into a corporate finance environment of ...
Andrei Shleifer, Daniel Wolfenson
core  

Insights into a long life without cancer: The case of the bowhead whale

open access: yesMolecular Oncology, EarlyView.
Long‐lived, large‐bodied organisms have evolved powerful anticancer mechanisms that preserve cellular and tissue integrity across extended lifespans. A recent study by Firsanov et al. shows that greater genome stability is a key factor underlying the remarkable longevity and cancer resistance of one such species, the bowhead whale.
Inés Paniagua, Johanna A. Joyce
wiley   +1 more source

Checkpoint blockade and the stem‐like T cell trade‐off

open access: yesMolecular Oncology, EarlyView.
Stem‐like T cells are key to the success of programmed cell death protein 1 (PD1) blockade, as they sustain long‐term anti‐tumor response by continuously generating effector CD8+ T cells. However, how these cells are maintained in cancer is not fully understood. Hor et al.
Julie M. Mazet, Johanna A. Joyce
wiley   +1 more source

Metastasis on pause: How dormant tumor cells stay hidden within the tumor microenvironment and evade immune surveillance

open access: yesMolecular Oncology, EarlyView.
Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary   +1 more
wiley   +1 more source

Seeds of Transformative Change [PDF]

open access: yesEcocene: Cappadocia Journal of Environmental Humanities, 2020
Steven Hartman, Serpil Oppermann
doaj   +1 more source

Selection of Marine Conservation Zones

open access: yes, 2013
Marine Conservation Zones may contribute to the protection and recovery of the marine environment. This POSTnote examines the process and approach used to select and designate zones, and difficulties in identifying and managing suitable ...
Brown, Alastair, Wentworth, Jonathan
core  

ECOLOGICAL SAFETY OF THE REGIONS: ACHIEVING THE EU STANDARDS [PDF]

open access: yes, 2012
On the basis of comparative analysis of the results of economic, production and environ- mental activity and indexes that testify the quality of life in context of environment of European countries the main trends of maintaining the ecological safety ...
Yermoshkina, Olena
core  

dUTPase is essential in zebrafish development and possesses several single‐nucleotide variants with pronounced structural and functional consequences

open access: yesFEBS Open Bio, EarlyView.
dUTPases are involved in balancing the appropriate nucleotide pools. We showed that dUTPase is essential for normal development in zebrafish. The different zebrafish genomes contain several single‐nucleotide variations (SNPs) of the dut gene. One of the dUTPase variants displayed drastically lower protein stability and catalytic efficiency as compared ...
Viktória Perey‐Simon   +6 more
wiley   +1 more source

Oxidation and protection of fiberglass-epoxy composite masts for photovoltaic arrays in the low Earth orbital environment [PDF]

open access: yes
Fiberglass-epoxy composites are considered for use as structural members for the mast of the space station solar array panel. The low Earth orbital environment in which space station is to operate is composed mainly of atomic oxygen, which has been shown
Brady, Joyce A.   +3 more
core   +1 more source

How New York City Used an Ecosystem Services Strategy Carried Out Through an Urban-rural Partnership to Preserve the Pristine Quality of its Drinking Water and Save Billions of Dollars [PDF]

open access: yes, 2010
The New York City watershed protection program may be the most well known example of economics driving a decision to invest in water based ecosystem services.
Albert F. Appleton
core  

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