Results 201 to 210 of about 184,615 (231)

Kidney‐Targeted Cilastatin Nanoparticles Inhibit DPEP1‐Mediated Ferroptosis for Acute Kidney Injury Therapy

Advanced Science, EarlyView.
In this study, MPDA NPs were engineered to encapsulate CTT. To further increase renal accumulation of CTT, L‐serine was conjugated to the surface of the MPDA nanoparticles (CTT/MPDA@L‐Ser NPs). CTT/MPDA@L‐Ser NPs inhibit DPEP1 activity, thereby restoring ferroptosis defense mechanisms through upregulation of GPX4 and SLC7A11 expression, ultimately ...
Wanbing Qin, Jiaqi Huang, Manting Zhang, Wanchun Yang, Mingwei Xu, Chi Jiang, Jiekai Li, Jinjuan Wen, Qibin Huang, Shiqi Wen, Weidong Wang, Junbing He, Qinghua Liu   +12 more
wiley   +1 more source

Latin America and the Caribbean: Socioeconomic Realities and Implications for Health and HIV Responses. [PDF]

J Int AIDS Soc
Cortes CP, Pérez Casas C, Cahn P.
europepmc   +1 more source

A Multidimensional Engineering Strategy Reprograms Microglia via Targeted and Sustained‐Release Extracellular Vesicles for Spinal Cord Injury Repair

Advanced Science, EarlyView.
A multifunctional EV‐based nanoplatform (Ang‐TEVs@Gel) was engineered via preconditioning, surface targeting, and ROS‐responsive hydrogel encapsulation to reprogram microglia. This system restored autophagy via miR‐664a‐3p/PIK3CA axis, cleared myelin debris, resolved neuroinflammation, and promoted axon remyelination, ultimately achieving robust motor ...
Wu Xiong, Minhao Liu, Mingming Zheng, Jizhou Jia, Ziyan Zhu, Guang Kong, Jie Liu, Juan Wang, Wenbo Li, Qingyuan Wang, Qian Zhu, Peiran Chan, Tao Qin, Jiayang Wu, Yongjie Zhang, Chunming Tang, Cong Li, Jin Fan   +17 more
wiley   +1 more source

Patient Shielding in Computed Tomography: Analysis of Influencing Factors and a Conceptual Framework for Decision-Making. [PDF]

Healthcare (Basel)
Qiao Y, Liu H, Zhou Q, Tuo F.
europepmc   +1 more source

Chemical Bond‐Orchestrated Energy Depletion to Augment Lung Cancer Chemo‐Immunotherapy

Advanced Science, EarlyView.
This study grafted dichloroacetic acid (DCA) into perylenediimide (PDI) skeleton via ionic or covalent bond to create novel metabolic agent PDIC‐AC and PDIC‐NAC, explicitly elaborated the underlying energy metabolism and therapeutic mechanism, and developed a promising strategy for energy metabolism‐targeting chemo‐immunotherapy by chemical bond ...
Xuejie Zhao, Yuting Liu, Xiao Huang, Liwen Zhao, Chunli Li, Yongwei Huang   +5 more
wiley   +1 more source

Real-World Utilization of the Novavax Adjuvanted Recombinant Protein COVID-19 Vaccine in France During the 2022-2024 Period. [PDF]

Vaccines (Basel)
Read SH, Kutikova L, Gusto G, Kapnang R, Quignot N, Khachatryan A, El Guerche-Séblain C, Petit V, Fix J, Rousculp MD, Janssen C, Launay O.   +11 more
europepmc   +1 more source

Advances in Vaccines Against Infectious Diseases. [PDF]

Vaccines (Basel)
De-Simone SG.
europepmc   +1 more source

Using participatory epidemiology to understand differences in tick-borne disease perceptions from homeowners in the Ohio River valley. [PDF]

One Health
Bache EG, Matzkin P, Fleming J, Pesapane R, Tufts DM.   +4 more
europepmc   +1 more source

Pharmaceutical Sovereignty as HIV Justice: Colombia's Dolutegravir License and the Future of ART Access in Latin America. [PDF]

J Int AIDS Soc
Cifuentes LM, Brisson JB, Zea A, David PM.   +3 more
europepmc   +1 more source