Results 41 to 50 of about 148,709 (308)
Molecular Oncology, EarlyView.We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober +16 more
wiley +1 more source
, 2004 In this work, we describe a novel pulse mode shear horizontal-surface acoustic wave (SH-SAW) polymer coated biosensor that monitors rapid changes in both amplitude and phase.
Newton, Michael +9 more
core +1 more source
Protective and positioning devices in maxillofacial prosthodontics and radiotherapy: Overview
Technical Innovations & Patient Support in Radiation Oncology, 2022 Background: Radiation therapy (RT) is a common modality of treatment in patients with head and neck cancer, and can cause several oral complications.
W. El Hawari, O. Bentahar
doaj +1 more source
Finding novel vulnerabilities of hypomorphic BRCA1 alleles
Molecular Oncology, EarlyView.Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder +10 more
wiley +1 more source
MODELING PROTECTIVE DEVICES FOR DISTRIBUTION SYSTEMS WITH DISTRIBUTED GENERATION USING AN EMTP-TYPE TOOL [PDF]
, 2010 This paper presents the main features of a library of modules for representation of protective devices of distribution networks with distributed generation (DG). The impact of distributed generation in a distribution network depends, among other aspects,
Castro-Aranda,Ferley +5 more
core +1 more source
Molecular Oncology, EarlyView.The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka +9 more
wiley +1 more source
Revista Enfermagem UERJ, 2013 Este estudo descritivo-exploratório, prospectivo, com abordagem quantitativa teve como objetivo verificar a adesão dos profissionais de enfermagem ao uso dos equipamentos de proteção individual na realização do procedimento de aspiração endotraqueal por ...
Oleci Pereira Frota +4 more
doaj +2 more sources
Iranian Journal of Public Health, 2021 Background: The facemasks use has been discussed to prevent respiratory disease due airborne contamination. The aim of this study was to perform a systematic review about the face masks use to avoid airborne contamination during COVID-19 pandemic and ...
Danúbia Cunha Sá-Caputo +7 more
doaj +1 more source
Molecular Oncology, EarlyView.Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller +10 more
wiley +1 more source
FEBS Open Bio, EarlyView.Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane +11 more
wiley +1 more source