Results 61 to 70 of about 1,231,047 (308)

Crosstalk between the ribosome quality control‐associated E3 ubiquitin ligases LTN1 and RNF10

FEBS Letters, EarlyView.
Loss of the E3 ligase LTN1, the ubiquitin‐like modifier UFM1, or the deubiquitinating enzyme UFSP2 disrupts endoplasmic reticulum–ribosome quality control (ER‐RQC), a pathway that removes stalled ribosomes and faulty proteins. This disruption may trigger a compensatory response to ER‐RQC defects, including increased expression of the E3 ligase RNF10 ...
Yuxi Huang, Satoshi Hashimoto, Sota Ito, Chisato Kikuguchi, Miho Hoshi, Kiyoshi Yamaguchi, Yoichi Furukawa, Toru Suzuki, Toshifumi Inada   +8 more
wiley   +1 more source

Peptide‐based ligand antagonists block a Vibrio cholerae adhesin

FEBS Letters, EarlyView.
The structure of a peptide‐binding domain of the Vibrio cholerae adhesin FrhA was solved by X‐ray crystallography, revealing how the inhibitory peptide AGYTD binds tightly at its Ca2+‐coordinated pocket. Structure‐guided design incorporating D‐amino acids enhanced binding affinity, providing a foundation for developing anti‐adhesion therapeutics ...
Mingyu Wang, Grace Du, Charity Yongo‐Luwawa, Angelina Lu, Brett Kinrade, Kim Munro, Karl E. Klose, William D. Lubell, Peter Davies, Shuaiqi Guo   +9 more
wiley   +1 more source

First hospital outbreak of the globally emerging Candida auris in a European hospital [PDF]

, 2016
Background: Candida auris is a globally emerging multidrug resistant fungal pathogen causing nosocomial transmission. We report an ongoing outbreak of C. auris in a London cardio-thoracic center between April 2015 and July 2016.
Abdolrasouli, A, Armstrong-James, DPH, Chowdhary, A, Fisher, MC, Hagen, F, Hall, A, Meis, JF, Rhodes, JL, Ryan, L, Schelenz, S, Shackleton, J, Trimlett, R   +11 more
core   +2 more sources

Interplay between circadian and other transcription factors—Implications for cycling transcriptome reprogramming

FEBS Letters, EarlyView.
This perspective highlights emerging insights into how the circadian transcription factor CLOCK:BMAL1 regulates chromatin architecture, cooperates with other transcription factors, and coordinates enhancer dynamics. We propose an updated framework for how circadian transcription factors operate within dynamic and multifactorial chromatin landscapes ...
Xinyu Y. Nie, Jerome S. Menet
wiley   +1 more source

Whistleblower protection

Revista de Derecho, 2019
This paper consists in the analysis of the corruption in Uruguay and how the whistleblower protection could be the key to fighting against it. Beginning with the importance of the whistleblower protection to fighting corruption in a general aspect, the ...
Facundo Galeano
doaj  

Acolhimento familiar: uma alternativa de proteção para crianças e adolescentes Family foster care: a protective alternative for children and adolescents

Psicologia: Reflexão e Crítica, 2009
O acolhimento de crianças e adolescentes que vivenciam violação de direitos tem sido discutido no âmbito do desenvolvimento de políticas públicas e no meio acadêmico. Tais discussões visam elaborar diretrizes que garantam o direito à convivência familiar
Nina Rosa do Amaral Costa, Maria Clotilde Rossetti-Ferreira   +1 more
doaj   +1 more source

COVID-19: A review of protective measures

Cancer Research, Statistics, and Treatment, 2020
The coronavirus disease 2019 (COVID-19) started as a pneumonia of unknown etiology in 44 patients in the Wuhan city of China and has progressed into a pandemic affecting more than 4.7 million people to date.
Tanaya Kulkarni, Prerit Sharma, Pooja Pande, Rajat Agrawal, Swapnil Rane, Abhishek Mahajan   +5 more
doaj   +1 more source

Disordered but rhythmic—the role of intrinsic protein disorder in eukaryotic circadian timing

FEBS Letters, EarlyView.
Unstructured domains known as intrinsically disordered regions (IDRs) are present in nearly every part of the eukaryotic core circadian oscillator. IDRs enable many diverse inter‐ and intramolecular interactions that support clock function. IDR conformations are highly tunable by post‐translational modifications and environmental conditions, which ...
Emery T. Usher, Jacqueline F. Pelham
wiley   +1 more source

Acceptance and Adoption of Protective Measures During the COVID-19 Pandemic: The Role of Trust in Politics and Trust in Science

Social Psychological Bulletin, 2020
The United Nations have described the outbreak of the coronavirus disease 2019 (COVID-19) as the worst global crisis since the second world war. Behavioral protective measures, such as good hand hygiene and social distancing, may strongly affect ...
Simone Dohle, Tobias Wingen, Mike Schreiber   +2 more
doaj   +1 more source

The meaning of protective measurements [PDF]

Foundations of Physics, 1996
Protective measurements, which we have introduced recently, allow to measure properties of the state of a single quantum system and even the Schr dinger wave itself. These measurements require a protection, sometimes due to an additional procedure and sometimes due to the potential of the system itself.
Aharonov, Yakir, Anandan, Jeeva, Vaidman, Lev   +2 more
openaire   +2 more sources