Results 31 to 40 of about 7,140 (156)

Role of glucose and CcpA in capsule expression and virulence of Streptococcus suis

, 2011
Streptococcus suis is one of the most important pathogens in pigs and is also an emerging zoonotic agent. After crossing the epithelial barrier, S. suis causes bacteraemia, resulting in meningitis, endocarditis and bronchopneumonia.
Smith, H.E., Smith, H E, H. E. Smith, R. Goethe, Rohde, Manfred, Valentin-Weigand, P., M. Rohde, Goethe, R, J. Willenborg, Willenborg, J, de Greeff, A, Goethe, R., Willenborg, J., A. de Greeff, Valentin-Weigand, P, De Greeff, A., Greeff, A., De, P. Valentin-Weigand, Fulde, M., M. Fulde, Fulde, M, Rohde, M.   +21 more
core   +1 more source

Neutrophils Display Novel Partners of Cytosolic Proliferating Cell Nuclear Antigen Involved in Interferon Response in COVID-19 Patients

Journal of Innate Immunity
Introduction: Neutrophils are key players in the hyperinflammatory response during SARS-CoV-2 infection. The cytosolic proliferating cell nuclear antigen (PCNA) is a scaffolding protein highly dependent on the microenvironment status and known
Lucie Pesenti, Rodrigo de Oliveira Formiga, Nicola Tamassia, Elisa Gardiman, François Chable de La Héronnière, Sara Gasperini, Johana Chicher, Lauriane Kuhn, Philippe Hammann, Morgane Le Gall, Giovanni Saraceni-Tasso, Clémence Martin, Anne Hosmalin, Magali Breckler, Roxane Hervé, Patrice Decker, Maha Zohra Ladjemi, Frédéric Pène, Pierre-Régis Burgel, Marco A. Cassatella, Véronique Witko-Sarsat   +20 more
doaj   +1 more source

Autoantibodies to Joint‐Related Peptides Are Associated With Onset of Rheumatoid Arthritis in Presymptomatic Seronegative Individuals

Arthritis &Rheumatology, EarlyView.
Objective To identify autoantibodies in presymptomatic individuals that associate with the onset of rheumatoid arthritis (RA) and to distinguish early RA from osteoarthritis (OA), particularly in individuals lacking classic RA serologic markers. Methods We analyzed serum and plasma from three cohorts: presymptomatic individuals who later developed RA ...
Outi Sareila, Linda Johansson, Anders Lundquist, Monica Leu Agelii, Lei Cheng, Yibo He, Erik Lönnblom, Maria Andersson, Jan Kihlberg, Anders Esberg, Inger Gjertsson, Rikard Holmdahl, Solbritt Rantapää‐Dahlqvist   +12 more
wiley   +1 more source

RGD Peptide and PAD4 Inhibitor-Loaded Gold Nanorods for Chemo-Photothermal Combined Therapy to Inhibit Tumor Growth, Prevent Lung Metastasis and Improve Biosafety

International Journal of Nanomedicine, 2021
Yu Lu,1,2 Zidong Peng,1,2 Di Zhu,1,2 Yijiang Jia,1,2 Ayijiang Taledaohan,1,2 Yuanming Li,3 Jiawang Liu,4 Yanming Wang,5 Yuji Wang1,2 1Department of Medicinal Chemistry, College of Pharmaceutical Sciences of Capital Medical University, Beijing, 100069 ...
Lu Y, Peng Z, Zhu D, Jia Y, Taledaohan A, Li Y, Liu J, Wang Y, Wang Y   +8 more
doaj  

Targeting neutrophil extracellular traps in metabolic and immune niche: Nanomaterials for diabetes tissue regeneration

BMEMat, EarlyView.
The effects of NETs on regeneration of various diabetic tissues, and strategies targeting NETs for diabetes tissue regeneration. In the diabetic environment, NETs undergo complex metabolic and immune reprogramming, leading to dynamic changes in antibacterial and proinflammatory functions, and affecting regeneration of multiple systemic tissues.
Xinyi Jiang, Muxin Yue, Kai Mao, Boon Chin Heng, Noor Azlin Yahya, Yunsong Liu, Zheng Li   +6 more
wiley   +1 more source

Rheumatoid arthritisâspecific autoantibodies to peptidyl arginine deiminase type 4 inhibit citrullination of fibrinogen

, 2010
International audienceOBJECTIVE:Autoantibodies to citrullinated proteins are specific for rheumatoid arthritis (RA) and recognize epitopes centered by citrulline, a posttranslationally modified form of arginine. Peptidyl arginine deiminase type 4 (PAD-4),
Martin, Marielle, Isabelle Auger, Marielle Martin, Nathalie Balandraud, Balandraud, Nathalie, Roudier, Jean, Jean Roudier, Auger, Isabelle   +7 more
core   +1 more source

Intrinsically disordered chromatin protein NUPR1 binds to the enzyme PADI4 [PDF]

, 2023
The nuclear protein 1 (NUPR1) is an intrinsically disordered protein involved in stress-mediated cellular conditions. Its paralogue nuclear protein 1-like (NUPR1L) is p53-regulated, and its expression down-regulates that of the NUPR1 gene.
Araujo-Abad, Salomé, García-Morales, Pilar, Rizzuti, B., García-Morales, P., Santofimia-Castaño, Patricia, de Juan Romero, Camino, Juan Romero, Camino de, Neira, J. L., Iovanna, J., Juan Romero, C. de, Neira Faleiro, José Luis, Araujo-Abad, S., Santofimia-Castaño, P., Neira, José L., Rizzuti, Bruno, Iovanna, Juan   +15 more
core   +1 more source

Monitoring and Mitigation Strategies for Hazardous Compounds in Chinese Rice Wine (Huangjiu): A Comprehensive Review

Food Safety and Health, EarlyView.
This review elucidates the formation pathways and detection technologies for ethyl carbamate, biogenic amines, and higher alcohols in Huangjiu. It concludes that integrated control frameworks are essential to decouple safety risks from the metabolic processes responsible for flavor development.
Lulu Liu, Zhiqiang Kong, Lin Li, Yifan Zhang, Bei Fan, Minmin Li   +5 more
wiley   +1 more source

A compendium of extracellular vesicle biogenesis inhibitors: From bench to bedside

Interdisciplinary Medicine, EarlyView.
This review explores a decade of research on extracellular vesicles (EVs), detailing their biogenesis and roles in health and disease. It emphasizes EVs' relevance for potential medical applications covering various conditions such as cancer, neurodegeneration, inflammation, and infectious diseases, bridging experimental findings with clinical ...
Stefano Vecchione, Ana Talamillo, Juan M. Falcón‐Pérez   +2 more
wiley   +1 more source

PADI4-mediated citrullination of histone H3 stimulates HIV-1 transcription

Nature Communications
HIV-1 infection establishes a reservoir of long-lived cells with integrated proviral DNA that can persist despite antiretroviral therapy (ART). Certain reservoir cells can be reactivated to reinitiate infection.
Luca Love, Bianca B. Jütte, Birgitta Lindqvist, Hannah Rohdjess, Oscar Kieri, Piotr Nowak, J. Peter Svensson   +6 more
doaj   +1 more source