Results 51 to 60 of about 43,875 (179)

Emerging Role of Ferroptosis in Diabetes and Associated Complications: When Metabolic Dysregulation Meets Cell Death

Cell Proliferation, EarlyView.
This study identifies ferroptosis as a key driver of diabetes and its complications via iron metabolism and lipid peroxidation, elucidates organelle interactions underlying cell vulnerability, and provides insights for targeted therapies against metabolic disorders.
Zheng Wang, Ying Zhang, Yue Xu, Mengyuan Yang, Yuan Wei, Yuan Li, Tongyue Yang, Xu Wang, Chaona Yang, Qi Feng, Guolan Xing   +10 more
wiley   +1 more source

An update on the landscape of collagen bioactive fragments

The FEBS Journal, EarlyView.
The remodeling of the extracellular matrix releases collagen bioactive fragments, which exert molecular functions and regulate numerous biological processes via several signaling pathways. Here, we summarize the latest findings describing the roles of major bioactive fragments from collagens I, IV, VI, and XVIII in various physiological and ...
Sylvie Ricard‐Blum, Julie Fradette
wiley   +1 more source

Autoimmunity and Periodontitis

Journal of Periodontal Research, EarlyView.
In a microbe‐driven inflammatory environment, peptidyl‐arginine deiminase (PAD) enzymes from neutrophils and Porphyromonas gingivalis citrullinate both microbial and self‐antigens. B cell presentation of citrullinated or self‐mimicking epitopes activates T cells that assist B cells in antibody isotype switching, affinity maturation, epitope spreading ...
Massimo Costalonga, Vivek Thumbigere‐Math, Mark C. Herzberg   +2 more
wiley   +1 more source

An atlas of plant selenium metabolism

New Phytologist, EarlyView.
Summary Selenium (Se) is not only a rare and toxic element but also an essential micronutrient for humans and animals that is often in short supply. Terrestrial plants do not require Se, but it can have growth‐promoting or negative effects, depending on the exposure level.
Jeroen van der Woude, Mark G. M. Aarts, Michela Schiavon, Antony van der Ent   +3 more
wiley   +1 more source

Subclass III SnRK2 Kinases Coordinate Starch and Storage Protein Synthesis During Maize Kernel Development

Plant Biotechnology Journal, EarlyView.
ABSTRACT Enhancing both starch and protein accumulation is a key strategy for improving maize yield and quality. Achieving this goal requires an in‐depth understanding of the regulatory mechanisms that integrate these pathways. Here, we demonstrate that functionally redundant subclass III SNF1‐related protein kinase 2s (SnRK2s) act as central ...
Yayun Wang, Tiandan Long, Changqing Mao, Shan Feng, Qiang Liao, Yufeng Hu, Junjie Zhang, Hanmei Liu, Yinghong Liu, Xiujun Fan, Lei Gao, Canmei Cun, Binjie Xu, Daqiu Zhao, Jing Wang, Yubi Huang, Yangping Li   +16 more
wiley   +1 more source

A Single‐Base Mutation in TaWAK3‐B Reduces Plant Height via Cytoskeleton in Bread Wheat

Plant Biotechnology Journal, EarlyView.
ABSTRACT Introduction of Reduced height (Rht) genes into modern wheat cultivars has resulted in ‘Green Revolution’ that skyrocketed wheat grain yields worldwide since the 1960s. These ‘Green Revolution’ cultivars show shorter plant height, but higher lodging resistance and harvest index.
Naijiao Wang, Ruolin Bian, Dejie Du, Yunjie Liu, Yiao Ma, Zihao Jiang, Zhaoju Li, Yan Zhou, Xiangyu Zhang, Zhaoheng Zhang, Beilu Cao, Xiongtao Li, Zhaoyan Chen, Jie Liu, Qixin Sun, Zhongfu Ni, Lingling Chai   +16 more
wiley   +1 more source

MdRLKT1–MdRAX2–MdMKS1 Module Positively Regulating Resistance to Cytospora mali in Apple

Plant Biotechnology Journal, EarlyView.
ABSTRACT Valsa canker (caused by Cytospora mali = Valsa mali. C. mali) is one of the most destructive diseases affecting apple cultivation. The scarcity of natural germplasm resources with high resistance and immunity underscores the importance of exploring plant immune regulation factors of disease‐resistant breeding.
Yanan Tang, Guangyao Li, Yang Li, Yuzhu Wang, Hao Feng, Lili Huang   +5 more
wiley   +1 more source

Sweet Potato Gene Clusters Control Anthocyanin Biosynthesis and Leaf Morphology

Plant Biotechnology Journal, EarlyView.
ABSTRACT Sweet potato (Ipomoea batatas) exhibits diversity in pigmentation and leaf morphology, yet the genetic architecture and regulatory organisation underlying these traits remain poorly resolved, particularly with respect to organ‐specific control.
Dong An, Tiechen Shen, Shiyu Wu, Yanshen Li, Weijuan Fan, Mengxiao Yan, Yinghui Meng, Xinyi Wang, Ximing Xu, Zunfu Lv, Ling Yuan, Jun Yang, Guoquan Lu, Hongxia Wang   +13 more
wiley   +1 more source

Contextualized Metabolic Modelling Revealed Factors Affecting Isoflavone Accumulation in Soybean Seeds

Plant, Cell &Environment, EarlyView.
ABSTRACT Isoflavones, secondary metabolites with numerous health benefits, are predominantly found in legume seeds, especially soybean; however, their contents in domesticated soybean seeds are highly variable. Wild soybeans are known for higher seed isoflavone contents than cultivars. Here we used experimental and modelling approaches on wild soybean (
Carolina A. Contador, Ailin Liu, Ming‐Sin Ng, Yee‐Shan Ku, Siu H. J. Chan, Hon‐Ming Lam   +5 more
wiley   +1 more source

Evolutionary Conserved and Divergent Responses to Copper Zinc Superoxide Dismutase Inhibition in Plants

Plant, Cell &Environment, EarlyView.
ABSTRACT After an initial evolution in a reducing environment, life got successively challenged by reactive oxygen species (ROS), especially during the great oxidation event (GOE) that followed the development of photosynthesis. Therefore, ROS are deeply intertwined into the physiological, morphological and transcriptional responses of most present‐day
Stephanie Frohn, Fabian B. Haas, Benjamin G. Chavez, Bernd H. Dreyer, Erik V. Reiss, Anne Ziplys, Heiko Weichert, Saskia Hiltemann, José M. Ugalde, Andreas J. Meyer, John C. D'Auria, Stefan A. Rensing, Jos H. M. Schippers   +12 more
wiley   +1 more source