Results 221 to 230 of about 184,784 (335)

Multiple tyrosine protein kinases in rat hippocampalneurons: isolation of Ptk-3, a receptor expressed in proliferative zones of thedeveloping brain.

, 1994
Marina P. Sánchez, Peter Tapley, Sarbjit S. Saini, Baoyu He, Daniel Pulido, Mariano Barbacid   +5 more
openalex   +1 more source

Genomics Review of Selective RET Inhibitors Sensitivity in Thyroid Cancer Clinical Trials

American Journal of Medical Genetics Part C: Seminars in Medical Genetics, EarlyView.
ABSTRACT RET gene is a driver of thyroid cancer (TC) tumorigenesis. The incidence of TC has increased worldwide in the last few decades, both in medullary and follicular‐derived subtypes. Several drugs, including multikinase and selective inhibitors, have been explored.
Sara Gil‐Bernabé, Lucía García‐DeLaFuente, Alejandro García‐Álvarez, Ginesa García‐Rostán, Jaume Capdevila, Jorge Hernando   +5 more
wiley   +1 more source

A stress-responsive p38 signaling axis in choanoflagellates. [PDF]

RSC Chem Biol
Rutaganira FU, Coyle MC, Nguyen MHT, Hernandez I, Scopton AP, Dar AC, King N.   +6 more
europepmc   +1 more source

Quantitative profiling of protein tyrosine kinases in human cancer cell lines by multiplexed parallel reaction monitoring assays [PDF]

Mol Cell Proteomics, 2015
europepmc   +1 more source

Signal transduction through a biomolecular receptor tyrosine protein kinase composed of a platelet-derived growth factor receptor-CD4 chimera and the nonreceptor tyrosine protein kinase Lck.

, 1993
Dieter Adam, Sabine Klages, Philippe C. Bishop, S Mahajan, J A Escobedo, Joseph B. Bolen   +5 more
openalex   +1 more source

Targeting signaling pathways in neurodegenerative diseases: Quercetin's cellular and molecular mechanisms for neuroprotection

Animal Models and Experimental Medicine, EarlyView.
Quercetin regulates signaling pathways in neurodegenerative diseases, including NF‐κB, sirtuins, and PI3K/Akt. Studies show quercetin improves symptoms and pathology in neurodegenerative models. The study aims to incorporate laboratory research into practical medical treatment, focusing on quercetin's neuroprotective effects and optimal dosage ...
Md. Rezaul Islam, Md. Ibrahim Khalil Al‐Imran, Mehrukh Zehravi, Sherouk Hussein Sweilam, Mohammad Rakib Mortuza, Jeetendra Kumar Gupta, Thukani Sathanantham Shanmugarajan, Kadirvel Devi, Tanuja Tummala, Mohammed Ali Alshehri, Kalirajan Rajagopal, Mohammed Asiri, Irfan Ahmad, Talha Bin Emran   +13 more
wiley   +1 more source

Comprehensive transcriptome, miRNA and kinome profiling identifies new treatment options for personalized lung cancer therapy. [PDF]

Clin Transl Med
Zhong S, Börgeling Y, Zardo P, Jonigk D, Borlak J.   +4 more
europepmc   +1 more source

Characterization of two 85 kd proteins that associate with receptor tyrosine kinases, middle-T/pp60c-src complexes, and PI3-kinase

, 1991
Masayuki Otsu, I. Hiles, Ivan Gout, Michael Fry, Fernanda Ruiz‐Larrea, George Panayotou, Andrew R. Thompson, Ritu Dhand, J. Justin Hsuan, Nick Totty   +9 more
openalex   +1 more source

Application of humanized mice in the safety experiments of antibody drugs

Animal Models and Experimental Medicine, EarlyView.
The graphical abstract of this review highlights the critical role of humanized mice in the safety evaluation of antibody drugs. First, the inherent immunogenicity of antibody drugs can lead to the production of antidrug antibodies and hypersensitivity reactions on repeated administration.
Zhimin Sun, Mengyun Gu, Zixuan Yang, Lei Shi, Liyuan Zhao, Minhui Zheng, Yan Wang, Wei Zhang, Kexin Han, Naping Tang   +9 more
wiley   +1 more source

Two novel protein-tyrosine kinases, each with a second phosphotransferase-related catalytic domain, define a new class of protein kinase.

, 1991
Andrew F. Wilks, Ailsa G. Harpur, Raja R. Kurban, Stephen J. Ralph, G. Zürcher, Andrew Ziemiecki   +5 more
openalex   +1 more source