Results 181 to 190 of about 7,628,689 (242)

Increased activity of PRMT5-MEP50 complex improves survival of chromosomally unstable cancer cells by increasing tolerance to protein aggregation and proteotoxicity

Suarez Peredo Rodriguez MF, Jilderda LJ, Gaviria Agudelo C, Simon JE, Heberle AM, van Kaam A, Bakker PL, Hong C, Roorda M, Lavoie G, Roux PP, Oeckinghaus A, van Vugt MA, Thedieck K, Foijer F.   +14 more
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Biomolecular condensates at the nexus of cellular stress, protein aggregation disease and ageing

Nature Reviews Molecular Cell Biology, 2021
S. Alberti, A. Hyman
semanticscholar   +3 more sources

Food protein aggregation and its application.

Food Research International, 2022
The phenomenon of protein aggregation in food science is very common, but the formation mechanism is unclear. The formation of protein aggregates (PAs) is influenced by various factors, and aggregates with different sizes and shapes play an important ...
Zongshuai Zhu, Anthony Pius Bassey, Yaqi Cao, Yanlan Ma, Ming Huang, Hongshun Yang   +5 more
semanticscholar   +1 more source

Energy landscapes of protein aggregation and conformation switching in intrinsically disordered proteins.

Journal of Molecular Biology, 2021
The protein folding problem was apparently solved recently by the advent of a deep learning method for protein structure prediction called AlphaFold. However, this program is not able to make predictions about the protein folding pathways.
B. Strodel
semanticscholar   +1 more source

Protein Aggregation

Clinical Chemistry and Laboratory Medicine, 2001
Protein aggregation occurs in vivo as a result of improper folding or misfolding. Diverse diseases arise from protein misfolding and are now grouped under the term "protein conformational diseases", including most of the neurodegenerative disorders such as Alzheimer's disease, Parkinson's disease, the prion encephalopathies and Huntington's disease, as
MERLINI, GIAMPAOLO, BELLOTTI, VITTORIO, ANDREOLA, ALESSIA, PALLADINI, GIOVANNI, Obici L, Casarini S, Perfetti V.   +6 more
openaire   +3 more sources

Interface-mediated protein aggregation

Chemical Communications, 2023
Interfaces play a pivotal role in governing the assembly and aggregation of biopolymers, providing valuable insights into functions of biopolymer materials. A range of exquisite structures are formed through well-planned interactions between biological components and surfaces or interfaces.
Fei Tao, Qian Han, Peng Yang
openaire   +2 more sources

Freezing-induced protein aggregation - Role of pH shift and potential mitigation strategies.

Journal of Controlled Release, 2020
The aggregation behavior of two model proteins- i) bovine serum albumin (BSA) and ii) β-galactosidase (β-gal), was investigated by micro-flow imaging (MFI) during freeze-thaw cycling in phosphate buffered solutions. The pH shift was measured upon cooling
Alpana Ankush Thorat, Bhushan Munjal, T. Geders, R. Suryanarayanan   +3 more
semanticscholar   +1 more source

Protein aggregation and prionopathies

Pathologie Biologie, 2014
Prion protein and prion-like proteins share a number of characteristics. From the molecular point of view, they are constitutive proteins that aggregate following conformational changes into insoluble particles. These particles escape the cellular clearance machinery and amplify by recruiting the soluble for of their constituting proteins.
M, Renner, R, Melki
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Mechanisms of Protein Aggregation

Current Pharmaceutical Biotechnology, 2009
Aggregation or reversible self-association of protein therapeutics can arise through a number of different mechanisms. Five common aggregation mechanisms are described and their relations to manufacturing processes to suppress and remove aggregates are discussed.
John S, Philo, Tsutomu, Arakawa
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Effects of high pressure homogenization on faba bean protein aggregation in relation to solubility and interfacial properties

Food Hydrocolloids, 2018
High pressure homogenization profoundly impacted the globular protein aggregation, and subsequently also its solubility and interfacial properties, using faba bean protein as model. The aggregate size and apparent molecular weight were studied by dynamic
Jingqi Yang, G. Liu, Hongbo Zeng, Lingyun Chen   +3 more
semanticscholar   +1 more source