Results 241 to 250 of about 737,165 (295)

Combining antibody conjugates with cytotoxic and immune‐stimulating payloads maximizes anti‐cancer activity

Molecular Oncology, EarlyView.
Methods to improve antibody–drug conjugate (ADC) treatment durability in cancer therapy are needed. We utilized ADCs and immune‐stimulating antibody conjugates (ISACs), which are made from two non‐competitive antibodies, to enhance the entry of toxic payloads into cancer cells and deliver immunostimulatory agents into immune cells.
Tiexin Wang, Dong Jun Koo, Peter M. Tessier, Greg M. Thurber   +3 more
wiley   +1 more source

Antibiotic-Induced Gut Dysbiosis Modulates Alzheimer's Disease-Associated Gene Expression and Protein Aggregation in 3xTg-AD Mice via the Gut-Brain Axis. [PDF]

Brain Behav
Tettevi EJ, Simpong DL, Maina M, Adjei S, Asuming-Brempong E, Osei-Atweneboana MY, Ocloo A.   +6 more
europepmc   +1 more source

Loss of intracellular ATP affects axoplasmic viscosity and pathological protein aggregation in mammalian neurons. [PDF]

Sci Adv
Guillaud L, Garanzini A, Zakhia S, De la Fuente S, Dimitrov D, Boerner S, Terenzio M.   +6 more
europepmc   +1 more source

Induction of hepatitis B core protein aggregation targeting an unconventional binding site. [PDF]

Elife
Khayenko V, Makbul C, Schulte C, Hemmelmann N, Kachler S, Böttcher B, Maric HM.   +6 more
europepmc   +1 more source

Phenolic Acids Commonly Found in Natural Products Modulate Protein Aggregation in <i>Caenorhabditis elegans</i> Neurodegeneration Models. [PDF]

ACS Omega
Valle-Jiménez X, Osorio-Paz I, Alavez S.   +2 more
europepmc   +1 more source

Rapid discovery of cyclic peptide protein aggregation inhibitors by continuous selection. [PDF]

Nat Chem Biol
Yang L, Zhang J, Andon JS, Li L, Wang T.
europepmc   +1 more source

Co-translational protein aggregation and ribosome stalling as a broad-spectrum antibacterial mechanism. [PDF]

Nat Commun
Khodaparast L, Khodaparast L, Duran-Romaña R, Wu G, Houben B, Duverger W, De Vleeschouwer M, Konstantoulea K, Nysen F, Schalck T, Curwen DJ, Martin LL, Carpentier S, Scorneaux B, Michiels J, Schymkowitz J, Rousseau F.   +16 more
europepmc   +1 more source

Increased activity of PRMT5-MEP50 complex improves survival of chromosomally unstable cancer cells by increasing tolerance to protein aggregation and proteotoxicity

Suarez Peredo Rodriguez MF, Jilderda LJ, Gaviria Agudelo C, Simon JE, Heberle AM, van Kaam A, Bakker PL, Hong C, Roorda M, Lavoie G, Roux PP, Oeckinghaus A, van Vugt MA, Thedieck K, Foijer F.   +14 more
europepmc   +1 more source

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Protein Aggregation

Clinical Chemistry and Laboratory Medicine, 2001
Protein aggregation occurs in vivo as a result of improper folding or misfolding. Diverse diseases arise from protein misfolding and are now grouped under the term "protein conformational diseases", including most of the neurodegenerative disorders such as Alzheimer's disease, Parkinson's disease, the prion encephalopathies and Huntington's disease, as
MERLINI, GIAMPAOLO, BELLOTTI, VITTORIO, ANDREOLA, ALESSIA, PALLADINI, GIOVANNI, Obici L, Casarini S, Perfetti V.   +6 more
openaire   +3 more sources