Results 241 to 250 of about 3,196,863 (318)

Derivation and characterization of retinal pigment epithelium from urine‐derived iPSCs

FEBS Open Bio, EarlyView.
Age‐related macular degeneration causes vision loss via RPE dysfunction and loss. Traditional iPSC therapies rely on invasive biopsies, limiting scalability. Here, we utilize urine‐derived stem cells as an accessible source to generate u‐iPSCs, successfully differentiated into pigmented RPE. This “Urine‐to‐Retina” platform provides a promising path for
Daniella Beiner, Hainan Zhu, Carol Christine Bosholm, Heuy‐Ching Wang, Tracy Criswell, Anthony Atala, Jian‐Xing Ma, Yuanyuan Zhang   +7 more
wiley   +1 more source

A Low Protein Binding Electrospun Membrane Filter for Efficient Biological Media Sterilization. [PDF]

ACS Omega
Azeez A, Varrier RP, Varughese IA, Rema RC, Menon D, Menon KN.   +5 more
europepmc   +1 more source

Molecular dynamics simulations of positively selected codons in FcγRI reveal novel biochemical binding properties

FEBS Open Bio, EarlyView.
Evolutionary analysis across 32 placental mammals identified positive selection at residues H148 and W149 in the immune receptor FcγR1. Ancestral reconstruction combined with molecular dynamics simulations reveals how these mutations may influence receptor structure and dynamics, providing insight into the evolution of antibody recognition and immune ...
David A. Young, Omar Arias‐Gaguancela, Fiona Gibson, Morgan Grainger, Jodie Score, Amit Nathubhai, Mauricio Cafiero, Lee Richard Machado   +7 more
wiley   +1 more source

High throughput screening for the design of protein binding polymers. [PDF]

Chem Sci
Bapp C, Mustafa AZ, Cao C, Wanless EJ, Stenzel MH, Chapman R.   +5 more
europepmc   +1 more source

Acute caffeine treatment protects the developing retina from ischemia‐induced cell death

FEBS Open Bio, EarlyView.
Caffeine reduces cell death in the developing retina under ischemia (OGD). This effect does not involve BDNF upregulation or antioxidant pathways (NRF2/VEGF). Neuroprotection occurs mainly through adenosine A2A receptor antagonism, decreasing glutamate release and excitotoxicity, highlighting caffeine's potential as an acute neuroprotective agent in ...
Amanda Alves Nascimento, Danniel Pereira‐Figueiredo, Gabriella Grossi de Lima Dias, Gabriel Ferreira dos Santos, Mariana Rodrigues Pereira, Rafael Brito, Karin C Calaza   +6 more
wiley   +1 more source

Evaluation of teicoplanin protein-binding variability and clinical utility of its free serum concentration measurement. [PDF]

Sci Rep
Inno Y, Taogoshi T, Matsumoto A, Yokooji T, Matsuo H.   +4 more
europepmc   +1 more source

Automatic Explanation of Protein-Protein Binding Mechanism: A Preliminary Study. [PDF]

Comput Struct Bioinform (2024)
Tam JZ, Liu Y, Jain DS, Armstrong G, Chen BY.   +4 more
europepmc   +1 more source

Protein Binding Site Representation in Latent Space. [PDF]

Mol Inform
Lohmann F, Allenspach S, Atz K, Schiebroek CCG, Hiss JA, Schneider G.   +5 more
europepmc   +1 more source

Multifunctional N-substituted 2-pyridylbenzothiazole derivatives: singlet oxygen generation, protein binding, and photoactivated anticancer and antibacterial activities. [PDF]

RSC Adv
Mohamed HA, Abdel-Shafi AA, Miyatake H, El-Khouly ME, Nassrallah AA.   +4 more
europepmc   +1 more source