Results 111 to 120 of about 807,043 (313)

Epigenetic blind spots – the role of DNA methylation dynamics in stem cell‐based models of embryogenesis

FEBS Letters, EarlyView.
Embryo‐like structures (stembryos) are an innovative tool, but they are hindered by experimental variability and limited developmental potential. DNA methylation is crucial for mammalian development, but its status in stembryo models is poorly characterized.
Sara Canil, Anna Corrà, Annalisa Scapolatiello, Chengxiang Qiu, Gianluca Amadei   +4 more
wiley   +1 more source

Enrichment strategy and initial characterization of heterodimers enriched from a co-formulated cocktail of therapeutic antibodies against SARS-COV-2

mAbs
Co-formulation of multiple drug products is an efficient and convenient approach to simultaneously deliver multiple biotherapeutics with the potentially added benefit of a synergistic therapeutic effect. However, co-formulation also increases the risk of
Sophia Liu, Yuetian Yan, Cody M. Secor, Zachary R. Oberholtzer, Donna J. Skow, Mushhood Sheikh, Youmi Moon, Yue Fu, Cristinel Sandu, Shunhai Wang, Ning Li, Jennifer B. Nguyen, Michael P. Rosconi, Erica A. Pyles   +13 more
doaj   +1 more source

Evaluation of Burkholderia cepacia Complex Bacteria Pathogenicity Using Caenorhabditis elegans

Bio-Protocol, 2016
This protocol describes two biological assays to evaluate pathogenicity of Burkholderia cepacia complex (Bcc) strains against the nematode Caenorhabditis elegans.
Pietro Tedesco, Elia Di Schiavi, Fortunato Palma Esposito, Donatella de Pascale   +3 more
doaj   +1 more source

pH‐mediated activation of the lysosomal arginine sensor SLC38A9

FEBS Letters, EarlyView.
Cells monitor nutrient levels via the lysosomal transporter SLC38A9 to activate the mechanistic target of rapamycin complex 1 (mTORC1). This study reveals that SLC38A9 function is regulated by pH. We identified histidine 544 as a critical pH sensor that undergoes conformational changes to control amino acid efflux from lysosomes; therefore, it ...
Xuelang Mu, Ampon Sae Her, Tamir Gonen
wiley   +1 more source

A digital module-based experiential learning in protein biochemistry during the COVID-19 pandemic paradigm. [PDF]

Biochem Mol Biol Educ, 2023
Yap MKK.
europepmc   +1 more source

Biophysical approaches for studying viral entry

FEBS Letters, EarlyView.
Viruses infect all living organisms and have been responsible for major epidemics and pandemics. Their ongoing evolutionary battle with host defenses creates a constant need for improved tools to study viral behavior. Advancing methods to probe viral attachment, fusion, and genome release deepen our understanding of how infections begin and support the
Inbar Yosibash, Raya Sorkin
wiley   +1 more source

Protein Evolution and Design

, 2018
This article introduces the Protein Evolution and Design theme of the Annual Review of Biochemistry Volume 87.
von Heijne, Gunnar,, Gunnar von Heijne
core   +1 more source

A Comprehensive Review of BET Protein Biochemistry, Physiology, and Pathological Roles. [PDF]

Front Pharmacol, 2022
Ali HA, Li Y, Bilal AHM, Qin T, Yuan Z, Zhao W.   +5 more
europepmc   +1 more source

The human gut microbiome across the life course

FEBS Letters, EarlyView.
Despite significant individual variation and continuous change throughout life, the human gut microbiome follows some life stage‐specific trends. This article provides a brief overview of how gut microbiome composition shifts across different phases of life. Created in BioRender. Özkurt, E. (2026) https://BioRender.com/8q4nrnc.
Alise J. Ponsero, Basak Bahcivanci, Antonietta Hayhoe, Animesh Acharjee, Ezgi Özkurt   +4 more
wiley   +1 more source

Foundations of modern biochemistry /

, 1995
Contents. List of Contributors. Acknowledgements (M.G. Ord and L.A. Stocken). Introduction. Bioenergetics after 1960: From the Chemiosmotic Hypothesis to Structure-Based Molecular Mechanisms (S.J. Ferguson). Changing Views of Photosynthesis (F.R. Whatley)
Ord, Margery G., Stocken, Lloyd A.
core