Results 191 to 200 of about 790,336 (266)

Castration‐resistant prostate cancer cells are addicted to the high activity of cyclin‐dependent kinase 2

Molecular Oncology, EarlyView.
We show that emergence of castration‐resistant prostate (CRPC) is associated with significant upregulation of cyclins that positively regulate cyclin‐dependent kinase 2 (CDK2) and concomitant downregulation of CDK4 cyclins. This renders CRPC cells dependent on the high activity of CDK2, and CDK2 inhibitors synergistically sensitize CRPC cells to both ...
Joyeeta Chatterjee, Alessia Marin, Shivani Yalala, Harri M. Itkonen   +3 more
wiley   +1 more source

Partial FAK suppression promotes tumor growth, an effect reversed by macrophage p110δ PI3K inactivation

Molecular Oncology, EarlyView.
Partial inhibition of focal adhesion kinase (FAK) can paradoxically promote tumor growth, rather than simply producing a weaker antitumor effect than that observed with strong FAK suppression. In breast cancer and melanoma models, targeting p110δ PI3K, particularly in macrophages, counteracted these tumor‐promoting effects, highlighting the importance ...
Lydia Xenou, Niki Tzenaki, Anna Tsapara, Maria Tzardi, Evangelia A. Papakonstanti   +4 more
wiley   +1 more source

Author Correction: Muskelin is a substrate adaptor of the highly regulated Drosophila embryonic CTLH E3 ligase. [PDF]

EMBO Rep
Briney CA, Henriksen JC, Lin C, Jones LA, Benner L, Rains AB, Gutierrez R, Gafken PR, Rissland OS.   +8 more
europepmc   +1 more source

Unraveling the epigenetic code in cancer cell–tumor microenvironment crosstalk

Molecular Oncology, EarlyView.
Epigenetic regulation is a key driver of cancer development and progression. Diverse epigenetic alterations in cancer cells and components of the tumor microenvironment (TME) orchestrate their communication through multiple mechanisms. We discuss how the epigenetic code coordinates bidirectional cancer cell–TME crosstalk to promote cancer progression ...
Ji Hoon Park, Mi‐Young Kim
wiley   +1 more source

Haematological and plasma biochemistry reference intervals for free-ranging Australian pelicans. [PDF]

Conserv Physiol
Sullivan DA, Porter JL, Ward J, Ramp D, Brandis KJ.   +4 more
europepmc   +1 more source

Arginine methylation as a regulatory ratchet in cancer: From substrate selection to malignant‐state stabilization

Molecular Oncology, EarlyView.
Arginine methylation can be viewed as a persistence‐prone post‐translational modification regulated by a network of PRMTs. Competitive and compensatory interactions among PRMTs can redistribute methylation across substrate pools shaped by sequence, structural, spatial, and environmental layers, reinforcing RNA‐processing, chromatin, and signaling ...
So Hyun Kwon, Ji Min Lee
wiley   +1 more source

Proteomic characterization of adult Fasciola gigantica recovered from naturally infected buffaloes in Punjab Pakistan. [PDF]

PLoS One
Shahid K, Shahzad MI, Ehsan M, Hu RS, Yousaf A, Rivera G, Safdar M, Rashid M, Irfan Malik M, Mudasser Nazir M.   +9 more
europepmc   +1 more source

Valproic acid remodels phosphatidylglycerol homeostasis and epithelial-macrophage crosstalk in inflammatory signaling. [PDF]

iScience
Ďurišová I, Máčajová M, Zriniová I, Fábryová I, Meta M, Bábelová L, Bilčík B, Kvasnička A, Baláž M, Bernátová S, Petrezsélyová S, Filipp D, Hsu YH, Friedecký D, Čavarga I, Balážová M.   +15 more
europepmc   +1 more source

Optimal 1TEL-target protein linker character is target protein-dependent. Corrigendum. [PDF]

Acta Crystallogr D Struct Biol
Pedroza Romo MJ, Keliiliki A, Averett JC, Gonzalez JF, Noakes E, Wilson EW, Smith C, Averett B, Hansen D, Nickles R, Bradford M, Soleimani S, Smith T, Nawarathnage S, Samarawickrama P, Kelsch A, Bunn D, Stewart C, Abiodun W, Tsubaki E, Brown S, Doukov TI, Moody JD.   +22 more
europepmc   +1 more source

Alpha-synuclein and mitochondrial permeability transition pore interactions in rotenone-induced Parkinson's disease models: neuroprotective promise of cyclosporine A. [PDF]

Biochem Biophys Rep
Singh S, Bir A, Thakur R, Chauhan A, Ghosh A, Mittal A, Nayak AK, Chakrabarti SS, Chakrabarti S.   +8 more
europepmc   +1 more source