Results 191 to 200 of about 754,932 (265)

VIIIth scientific meeting of the Italian Association for Developmental and Comparative Immunology (IADCI), 1 and 2 March 2007, Area della Ricerca, CNR, Naples, Italy

Invertebrate Survival Journal, 2007
U Oreste, M R Coscia
doaj  

SLC25A3 exports mitochondrial copper to metalate cytochrome <i>c</i> oxidase and prevent cuproptosis. [PDF]

Proc Natl Acad Sci U S A
Zulkifli M, Farid I, Oldfather LE, Shanbhag VC, Leary SC, Petris MJ, Cobine PA, Gohil VM.   +7 more
europepmc   +1 more source

Pharmacological chromatin remodeling enhances response to estrogen therapy in ER+ breast cancer

Molecular Oncology, EarlyView.
Estrogen therapy elicits clinical benefit in ~ 30% of patients with endocrine‐resistant estrogen receptor (ER)‐positive breast cancer. Based on findings that ER transcriptional activation underlies response to estrogen therapy, we tested the effects of epigenetic dysregulation via pharmacological inhibition of histone deacetylases (HDACi).
Anneka L. Johnson Thomas, Barbara Karakyriakou, Patricia C. Muskus, Alyssa M. Roberts, Justin Rendleman, Alexa Warren, Hanxu Lu, Kimberly A. Birmingham, Malone K. Friedman, Abigail E. Goen, Huijuan Yang, Owen M. Wilkins, Fred W. Kolling, Eugene Demidenko, Julie M. Jorns, Brock C. Christensen, Todd W. Miller   +16 more
wiley   +1 more source

<i>S</i>-Palmitoylation in Health and Disease. [PDF]

Biochemistry
Wong W, Hu M, Isaacson RL.
europepmc   +1 more source

PANoptosis in the pathogenesis of myelodysplastic syndromes

Molecular Oncology, EarlyView.
PANoptosis, a combination of three types of programmed cell death, is mediated by a large protein complex called a PANoptosome. In healthy bone marrow hematopoietic cells, PANoptosis is restricted by inhibitory signaling. In MDS, bone marrow cells become sensitive to the PANoptotic stimuli due to the aberrant inactivation of inhibitory signaling or ...
Rohit Thalla, Jyoti Lamichhane, Cameron Lewis, Peter Breslin, Jiwang Zhang   +4 more
wiley   +1 more source

Endoglin is not a mediator in 7-ketocholesterol-induced endothelial activation in liver sinusoidal endothelial cells in vitro. [PDF]

Inflamm Res
Fikrova P, Tripska K, Eissazadeh S, Vasinova M, Diepoltova A, Rathouska JU, Nemeckova I, Havelek R, Mohammadi S, Igreja Sa IC, Nachtigal P.   +10 more
europepmc   +1 more source

Spatial biology in cancer epigenetics

Molecular Oncology, EarlyView.
Spatial epigenomics combines molecular profiling with tissue architecture to reveal how gene regulation is organized within intact tissues. In cancer, these technologies uncover the mechanisms driving tumor heterogeneity and microenvironmental interactions, opening new opportunities for biomarker discovery and precision medicine.
Eva Crespo‐García, Manel Esteller
wiley   +1 more source

Backbone Nitrogen Substitution Probes the Role of Glycine Residues at GxxxG Interfaces in Transmembrane Helices. [PDF]

Biochemistry
Thomas D, Gu F, Newberry RW.
europepmc   +1 more source

Cancer cell‐intrinsic type 1 interferon: production, signaling, and outcomes within sex‐biased, female malignancies

Molecular Oncology, EarlyView.
The cell‐autonomous roles of interferon type 1 vary based on duration and intensity. While acute, robust signaling results in cancer cell cytotoxic effects, sustained, low‐level signaling is associated with tumor‐promoting effects. This review summarizes current research of IFN‐1 in cancer and within the clinical setting, with an emphasis on female ...
Ashlyn Conant, Nora Badiner, Sharon Asariah, Kiera McGivney, Vishwa Shah, Tise Suzuki, Yevgeniya J. Ioffe, Juli J. Unternaehrer   +7 more
wiley   +1 more source

Signaling Bias as a Framework for Therapeutically Relevant Orthosteric Agonists: The β₂ Adrenergic Receptor Paradigm. [PDF]

Biochemistry
Georgiou K, Kolocouris A.
europepmc   +1 more source