Results 231 to 240 of about 6,634,608 (387)

Protein conformation as a regulator of cell-matrix adhesion.

Physical Chemistry, Chemical Physics - PCCP, 2014
V. Hytönen, B. Wehrle-Haller
semanticscholar   +1 more source

Indoleamine 2,3‐dioxygenase 1 inhibition reverses cancer‐associated fibroblast‐mediated immunosuppression in high‐grade serous ovarian cancer

FEBS Open Bio, EarlyView.
CAF‐mediated immunosuppression in ovarian cancer is driven by IDO1, reducing T‐cell function. Inhibiting IDO1 restores T‐cell proliferation and cytotoxicity, increases cancer cell apoptosis, and may help overcome CAF‐induced immune suppression in high‐grade serous ovarian cancer. Targeting IDO1 may improve antitumor immunity.
Hyewon Lee, Jung Yoon Ho, In Sun Hwang, Youn Jin Choi   +3 more
wiley   +1 more source

Spatially resolved profiling of protein conformation and interactions by biocompatible chemical cross-linking in living cells. [PDF]

Nat Commun
Zhao L, An Y, Zhao N, Gao H, Zhang W, Gong Z, Liu X, Zhao B, Liang Z, Tang C, Zhang L, Zhang Y, Zhao Q.   +12 more
europepmc   +1 more source

Interplay between Conformational Entropy and Solvation Entropy in Protein–Ligand Binding

, 2019
Maria Luisa Verteramo, Olof Stenström, Majda Misini Ignjatović, Octav Caldararu, Martin Olsson, Francesco Manzoni, Hakon Leffler, Esko Oksanen, Derek T. Logan, Ulf J. Nilsson, Ulf Ryde, Mikael Akke   +11 more
openalex   +1 more source

A two‒dimensional IR spectroscopic (2D‒IR) simulation of protein conformational changes [PDF]

, 2004
José Luis R. Arrondo, Ibón Iloro, Julián Aguirre, Félix M. Goñi   +3 more
openalex   +1 more source

A general model for analysis of linear and hyperbolic enzyme inhibition mechanisms

FEBS Open Bio, EarlyView.
We developed a general enzyme kinetic model that integrates these six basic inhibition mechanism onto a single one. From this model, we deduced a general enzyme kinetic equation that through modulation of simple parameters, γ (the relative inhibitor affinity for two binding sites) and β (the reactivity of the enzyme–substrate–inhibitor complex), is ...
Rafael S. Chagas, Sandro R. Marana
wiley   +1 more source

Epigallocatechin-3-gallate improved rheological properties of rice bran protein-soybean protein isolate conjugates emulsions by regulating interface protein conformation. [PDF]

Food Chem X
Zhao M, Wei X, Wu X, Lin L, Wu W.
europepmc   +1 more source

HSP70 governs permeability and mechanotransduction in primary human endothelial cells

FEBS Open Bio, EarlyView.
HSP70 chemical inhibition reduces endothelial cell proliferation and increases permeability, the latter supported by normal interendothelial junctional protein distribution. HSP70 also plays a role in shear stress response, a hemodynamic force naturally present in blood vessels and correlated with vessel protection.
Andrea Pinto‐Martinez, Everton G. Melo, Isadora C. B. Pavan, Percíllia V. S. Oliveira, Luiza B. C. T. Coimbra, Thaís L. S. Araujo   +5 more
wiley   +1 more source

Identification of Potential Selective PAK4 Inhibitors Through Shape and Protein Conformation Ensemble Screening and Electrostatic-Surface-Matching Optimization. [PDF]

Curr Issues Mol Biol
Zhang X, Zhang M, Li Y, Deng P.
europepmc   +1 more source

Conformational flexibility of GRASP protein and its constituent PDZ subdomains reveals structural basis of its promiscuous interactome [PDF]

, 2019
Luís F.S. Mendes, Mariana Batista, Peter J. Judge, Anthony Watts, Christina Redfield, Antonio J. Costa‐Filho   +5 more
openalex   +1 more source