Results 271 to 280 of about 6,634,608 (387)

N-acetyl cysteine: A tool to perturb SARS-CoV-2 spike protein conformation

, 2021
Debnath U, Mitra A, Dewaker V, Prabhakar YS, Tadala R, Krishnan K, Wagh P, Velusamy U, Subramani C, Agarwal S, Vrati S, Baliyan A, Kurpad AV, Bhattacharyya P, Mandal A.   +14 more
europepmc   +1 more source

Cloning, expression and enzyme activity delineation of two novel CANT1 mutations: the disappearance of dimerization may indicate the change of protein conformation and even function. [PDF]

Orphanet J Rare Dis, 2020
Wang HD, Guo LJ, Feng ZQ, Zhang DW, Zhang MT, Gao Y, Chen CL, Zhu BF.   +7 more
europepmc   +1 more source

Tetrahymena Telomerase Protein p65 Induces Conformational Changes throughout Telomerase RNA (TER) and Rescues Telomerase Reverse Transcriptase and TER Assembly Mutants

, 2010
Andrea J. Berman, Anne R. Gooding, Thomas R. Cech   +2 more
openalex   +2 more sources

Pathogenic Neurofibromatosis type 1 gene variants in tumors of non‐NF1 patients and role of R1276

FEBS Open Bio, EarlyView.
Somatic variants of the neurofibromatosis type 1 (NF1) gene occur across neoplasms without clinical manifestation of the disease NF1. We identified emerging somatic pathogenic NF1 variants and hotspots, for example, at the arginine finger 1276. Those missense variants provide fundamental information about neurofibromin's role in cancer.
Mareike Selig, Swanhild Lohse, Sara Elahi, Nils Hartmann, Stefanie Deckert, Shutian Si, Alexander Desuki, Anja Harder   +7 more
wiley   +1 more source

Effect of Protein Conformation and AMP Protonation State on Fireflies' Bioluminescent Emission. [PDF]

Molecules, 2019
Garcia-Iriepa C, Navizet I.
europepmc   +1 more source

Automated FRAP microscopy for high‐throughput analysis of protein dynamics in chromatin organization and transcription

FEBS Open Bio, EarlyView.
RoboMic is an automated confocal microscopy pipeline for high‐throughput functional imaging in living cells. Demonstrated with fluorescence recovery after photobleaching (FRAP), it integrates AI‐driven nuclear segmentation, ROI selection, bleaching, and analysis.
Selçuk Yavuz, Bart Geverts, Johan A. Slotman, Andrea Sacchetti, Stefan Prekovic, Martin E. van Royen, Adriaan B. Houtsmuller   +6 more
wiley   +1 more source

Conformational Changes in Ribosomes during Protein Synthesis

, 1971
Max H. Schreier, Hans Noll
openalex   +2 more sources

Raman‐based label‐free microscopic analysis of the pancreas in living zebrafish larvae

FEBS Open Bio, EarlyView.
Forward stimulated Raman scattering (F‐SRS) and epi coherent anti‐Stokes Raman scattering (E‐CARS) allow label‐free discrimination of distinct subcellular structures in the pancreas of living zebrafish larvae. Given the straightforward applicability, we anticipate broad implementation of Raman microscopy in other organs and across various biomedical ...
Noura Faraj, Eline M. F. de Lange, Klaas A. Sjollema, Ben N. G. Giepmans   +3 more
wiley   +1 more source

Engineering tandem VHHs to target different epitopes to enhance antibody‐dependent cell‐mediated cytotoxicity

FEBS Open Bio, EarlyView.
Tandem VHH targeting distinct EGFR epitopes were engineered into a monovalent bispecific antibody (7D12‐EGA1‐Fc) with more potent ADCC without increasing affinity to EGFR. Structural modeling of 7D12‐EGA1‐Fc showed cross‐linking of separate EGFR domains to enhance CD16a engagement on NK cells.
Yuqiang Xu, Hao Jiang, Limin Chen, Fulai Zhou, Ying Jin, Mark L. Chiu   +5 more
wiley   +1 more source

Role of surface functionalization and biomolecule structure on protein corona adsorption and conformation onto anisotropic metallic nanoparticles

Valeria Figueroa Velarde, Brenda Velasco, Lilia Arellano, Vicente Domínguez-Arca, Adriana Cambón, Alberto Pardo, Antonio Topete, Luis Carlos Rosales‐Rivera, J. F. A. Soltero, Sílvia Barbosa, Pablo Taboada   +10 more
openalex   +1 more source