Results 271 to 280 of about 6,498,873 (334)

Conformation of Polypeptides and Proteins

1968
Publisher Summary This chapter deals with the recent developments regarding the description and nature of the conformation of proteins and polypeptides with special reference to the stereochemical aspects of the problem. This chapter considers the parameters that are required for an adequate description of a polypeptide chain.
Ramachandran, GN, Sasisekharan, V
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Conformational spectra — probing protein conformational changes

Biophysical Chemistry, 1999
Stafford [Biophys. J. 17 (1996) MP452] has shown that it is possible, using the analytical ultracentrifuge in sedimentation velocity mode, to calculate the molecular weights of proteins with a precision of approximately 5%, by fitting Gaussian distributions to g(s*) profiles so long as partial specific volume and the radial position of the meniscus are
Arthur J. Rowe, Olwyn Byron, Neil Errington   +2 more
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Protein Conformation Generation via Force-Guided SE(3) Diffusion Models

International Conference on Machine Learning
The conformational landscape of proteins is crucial to understanding their functionality in complex biological processes. Traditional physics-based computational methods, such as molecular dynamics (MD) simulations, suffer from rare event sampling and ...
Yan Wang, Lihao Wang, Yuning Shen, Yiqun Wang, Huizhuo Yuan, Yue Wu, Quanquan Gu   +6 more
semanticscholar   +1 more source

Protein conformational prediction

Trends in Biochemical Sciences, 1989
The prediction of the secondary and tertiary structure of globular and membrane proteins is reviewed. Prospects are encouraging for future developments, but present algorithms require cautious interpretation.
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Conformation of the Backbone in Unfolded Proteins

Chemical Reviews, 2006
AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Zhengshuang Shi, Kang Chen, Zhigang Liu, Neville R. Kallenbach   +3 more
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Reflection methods for inverse problems with applications to protein conformation determination

, 2014
The Douglas–Rachford reflection method is a general-purpose algorithm useful for solving the feasibility problem of finding a point in the intersection of finitely many sets.
J. Borwein, Matthew K. Tam
semanticscholar   +1 more source

Conformational stability of globular proteins

Trends in Biochemical Sciences, 1990
The conformational stability of ribonuclease T1 has been measured as a function of the variables of most interest to biochemists: temperature, pH, salt concentration, disulfide-bond content and amino acid sequence. The results provide insight into the forces that stabilize globular proteins.
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Conformation of terminal regions in proteins

Nature, 1982
A carboxy-terminal helix has been observed in many proteins, suggesting that these helices confer an advantage, perhaps by providing protection against carboxypeptidase activity. To determine whether the conformational preferences of the amino- and carboxy-terminal regions are significantly different from each other and from the rest of the protein, we
Janet M. Thornton, Bancinyane L. Chakauya   +1 more
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Characterizing Intermediate Conformations in Protein Conformational Space

2013
In this paper we present a novel parallel coordinate based clustering method using Gaussian mixture distribution models to characterize the conformational space of proteins. We detect highly populated regions which may correspond to intermediate states that are difficult to detect experimentally.
Nurit Haspel, Rosanne Vetro, Dan A. Simovici   +2 more
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Conformational mobility of immobilized proteins

Journal of Pharmaceutical and Biomedical Analysis, 2007
Cellular membrane fragments have been immobilized on the surface of a silica-based liquid chromatographic support and on the surface of glass capillaries to create immobilized receptor and drug transporter columns. These columns have included phases containing one subtype of the nicotinic receptor (alpha3beta2, alpha3beta4, alpha4beta2, alpha4beta4 ...
Irving W. Wainer, Ruin Moaddel
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