Results 91 to 100 of about 16,987,595 (305)

Conserved binding mode but diverse interfaces of MreC‐PBP2 interactions

FEBS Letters, EarlyView.
The crystal structure of abMreC reveals a conserved two β‐barrel architecture and provides structural insights into its role within the bacterial elongasome. The abMreC–abPBP2 complex model identifies the molecular basis of MreC‐mediated PBP2 recognition, contributing to the regulation of peptidoglycan synthesis.
Hyunseok Jang, Hyo Been Jin, Chang Min Kim, So Yeon Lee, Hyun Ho Park   +4 more
wiley   +1 more source

Implications of molecular interactions for protein structure, function and design [PDF]

, 2005
Protein structures are kept in a delicate balance of stability by the interactions of the amino acid residues among themselves, the solvent and other molecules. On one hand they must be stable enough not to unfold, on the other hand they must be mobile
Meier, Markus
core   +1 more source

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

FEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta, Hari Baskar Balasubramanian, Amir Pasokh, Marietta Zille   +3 more
wiley   +1 more source

TIMED-Design: Flexible and Accessible Protein Sequence Design with Convolutional Neural Networks [PDF]

<p>Models for the paper "**TIMED-Design: Flexible and Accessible Protein Sequence Design with Convolutional Neural Networks**"</p> <p># Performance Comparison</p> <p>For detailed performance comparisons, please see the paper.
Subr, Kartic, Castorina, Leonardo V., Wood, Christopher W., Wood, Christopher, Castorina, Leonardo V, Ünal, Suleyman Mert   +5 more
core   +1 more source

In silico peptide-directed ligand design complements experimental peptide-directed binding for protein–protein interaction modulator discovery [PDF]

, 2020
Using the protein–protein interaction of Mcl-1/Noxa, two methods for efficient modulator discovery are directly compared. In silico peptide-directed ligand design is evaluated against experimental peptide-directed binding, allowing for the discovery of ...
Beekman, Andrew Michael, Howell, LA, Lesley A., Howell, Andrew, Beekman, Howell, Lesley Ann, Beekman, AM, Andrew Michael Beekman, Lesley Ann Howell   +7 more
core   +3 more sources

Structure‐forward targeting of claudins with synthetic binders

FEBS Letters, EarlyView.
Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley   +1 more source

Biochemical Society Transactions www.biochemsoctrans.org Protein Engineering: New Approaches and Applications

, 2014
Protein engineering is at an exciting stage because designed protein–protein interactions are being used in many applications. For instance, three designed proteins are now in clinical trials. Although there have been many successes over the last decade,
Nextgen Protein Design
core  

Monitoring Protein Aggregation Kinetics In Vivo using Automated Inclusion Counting in Caenorhabditis elegans [PDF]

, 2021
Protein aggregation into insoluble inclusions is a hallmark of a variety of human diseases, many of which are age-related. The nematode Caenorhabditis elegans is a well-established model organism that has been widely used in the field to study protein ...
Sinnige, Tessa, Molenkamp, Jelle, van Schijndel, Vera, den Outer, Anna, Sub Cellular Protein Chemistry, Sub Membrane Biochemistry & Biophysics, Membrane Biochemistry and Biophysics, Cellular Protein Chemistry   +7 more
core  

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

Rational protein design

Current Opinion in Structural Biology
Protein design enables the creation of novel structures and functions beyond those found in nature, with recent progress accelerated by computational modeling and machine learning. However, many automated methods act as black boxes, limiting mechanistic insight.
Joel J. Chubb, Aimee L. Boyle, Katherine I. Albanese   +2 more
openaire   +2 more sources