Results 271 to 280 of about 16,987,595 (305)

Designing proteins with cavities

Science, 2017
Protein Design In de novo protein design, creating custom-tailored binding sites is a particular challenge because these sites often involve nonideal backbone structures. For example, curved b sheets are a common ligand binding motif. Marcos et al.
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Designed Protein Origami

2016
Proteins are highly perfected natural molecular machines, owing their properties to the complex tertiary structures with precise spatial positioning of different functional groups that have been honed through millennia of evolutionary selection. The prospects of designing new molecular machines and structural scaffolds beyond the limits of natural ...
Igor, Drobnak, Ajasja, Ljubetič, Helena, Gradišar, Tomaž, Pisanski, Roman, Jerala   +4 more
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Protein engineering and design

Philosophical Transactions of the Royal Society of London. B, Biological Sciences, 1989
Abstract Rapid advances in site-directed mutagenesis and total gene synthesis combined with new expression systems in prokaryotic and eukaryotic cells have provided the molecular biologist with tools for modification of existing proteins to improve catalytic activity, stability and selectivity, for construction of chimeric molecules ...
Blundell, T L, Elliott, G, Gardner, S P, Hubbard, T, Islam, S, Johnson, M, Mantafounis, D, Murray-Rust, P, Overington, J, Pitts, J E, Sali, A, Sibanda, B.L., Singh, J., Sternberg, M.J.E., Sutcliffe, M.J., Thorton, J.M., Travers, P.   +16 more
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Algorithms for protein design

2022
Computational Protein Design has the potential to contribute to major advances in enzyme technology, vaccine design, receptor-ligand engineering, biomaterials, nanosensors, and synthetic biology. Although Protein Design is a challenging problem, proteins can be designed by experts in Protein Design, as well as by non-experts whose primary interests are
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Design of Peptides and Proteins

1988
Publisher Summary This chapter focuses on contemporary approaches to the design of structurally defined peptides and proteins with special emphasis being given to the ways in which this approach has elucidated the structural basis for the function of a variety of natural molecules.
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Carbohydrates in peptide and protein design

Peptide Science, 2005
AbstractMonosaccharides and amino acids are fundamental building blocks in the assembly of nature's polymers. They have different structural aspects and, to a significant extent, different functional groups. Oligomerization gives rise to oligosaccharides and peptides, respectively. While carbohydrates and peptides can be found conjoined in nature, e.g.,
Jensen, Knud J., Brask, Jesper
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Design of Protein Catalysts

Annual Review of Biochemistry, 2013
Diverse engineering strategies have been developed to create enzymes with novel catalytic activities. Among these, computational approaches hold particular promise. Enzymes have been computationally designed to promote several nonbiological reactions, including a Diels-Alder cycloaddition, proton transfer, multistep retroaldol transformations, and ...
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Optimal Protein Design Procedure

Physical Review Letters, 1996
We discuss a general method for protein design based on an analysis in sequence space of the Boltzmann weight for a given target structure. An efficient Monte Carlo code that explores sequence space (and, for each sequence, the space of compact and noncompact conformations) is implemented and tested in two models in two dimensions which are amenable to
SENO, FLAVIO, M. Vendruscolo, MARITAN, AMOS, J. R. Banavar   +3 more
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Automatic Procedures for Protein Design

Combinatorial Chemistry & High Throughput Screening, 2001
This review describes computational procedures for deriving the amino acid sequences that are compatible with a given protein backbone structure. Such procedures can be used to gain insight into the constraints imposed by the 3D structure of the protein sequence, or to design proteins that are likely to adopt a given backbone conformation.
Jaramillo, Alfonso, Wernisch, Lorenz, Hery, Stéphanie, Wodak, Shoshana   +3 more
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Designing Fluorinated Proteins

2016
As methods to incorporate noncanonical amino acid residues into proteins have become more powerful, interest in their use to modify the physical and biological properties of proteins and enzymes has increased. This chapter discusses the use of highly fluorinated analogs of hydrophobic amino acids, for example, hexafluoroleucine, in protein design.
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