Results 271 to 280 of about 16,988,925 (342)

Engineering Protein Dynamics through Mutational Energy Landscape Traps. [PDF]

J Chem Inf Model
Machado LA, Sartori J, Franklin PFDC, Costa MGS, Guimarães ACR.   +4 more
europepmc   +1 more source

Transcripts enriched in codons that trigger P‐site tRNA‐mediated mRNA decay possess stable mRNA

FEBS Open Bio, EarlyView.
PTMD codons were first described by Mendel et al. as mediators of an mRNA decay pathway dependent on the human protein CNOT3, homologous to yeast Not5. Our findings confirm that PTMD codons destabilize transcripts; however, unlike in yeast, the human pathway specifically targets and slightly destabilizes primarily stable mRNAs.
Rodolfo Lopes Carneiro, Fernando Lucas Palhano   +1 more
wiley   +1 more source

Decoding protein dynamics with limited proteolysis coupled to mass spectrometry: A comprehensive review. [PDF]

J Pharm Anal
Zhao Z, Zhang X, Dong X, Hong Z.
europepmc   +1 more source

Hyperosmotic stress‐induced redistribution of pre‐mRNA cleavage factor I subunits is associated with shifts in alternative polyadenylation

FEBS Open Bio, EarlyView.
Hyperosmotic stress triggers the relocation of the CFIm complex from the nucleus to the cytoplasm. This shift creates a nuclear ‘stoichiometric bottleneck’, limiting CFIm availability for mRNA processing. Consequently, specific mRNAs like NUDT21 and DICER1 undergo targeted 3′UTR shortening, demonstrating how spatial protein dynamics drive rapid ...
Hitomi Soumiya, Masatake Osawa, Hidefumi Fukumitsu   +2 more
wiley   +1 more source

Protein dynamics underlies strong temperature dependence of heat receptors. [PDF]

Proc Natl Acad Sci U S A
Mugo AN, Chou R, Qin F.
europepmc   +1 more source

Push-and-pull protein dynamics leads to log-normal synaptic sizes and probabilistic multi-spine plasticity

Petkovic J, Eggl MF, Pathirana D, Chater TE, Hasenauer J, Rizzoli S, Tchumatchenko T.   +6 more
europepmc   +1 more source

Protein folding, protein dynamics and the topology of self-motions. [PDF]

R Soc Open Sci
Hayward S.
europepmc   +1 more source

Quantitative Chromatin Protein Dynamics During Replication Origin Firing in Human Cells. [PDF]

Mol Cell Proteomics
Gadi SA, Hendriks IA, Nielsen CF, Popova P, Hickson ID, Nielsen ML, Toledo L.   +6 more
europepmc   +1 more source

Publisher Correction: RAPP-containing arrest peptides induce translational stalling by short circuiting the ribosomal peptidyltransferase activity

Nature Communications
Martino Morici, Sara Gabrielli, Keigo Fujiwara, Helge Paternoga, Bertrand Beckert, Lars V. Bock, Shinobu Chiba, Daniel N. Wilson   +7 more
doaj   +1 more source

Automated Engineering Protein Dynamics via Loop Grafting: Improving Renilla Luciferase Catalysis. [PDF]

ACS Catal
Planas-Iglesias J, Majerova M, Pluskal D, Vasina M, Damborsky J, Prokop Z, Marek M, Bednar D.   +7 more
europepmc   +1 more source