Results 91 to 100 of about 6,813,928 (408)
Exposure Risk of Chronic Wasting Disease in Humans
Viruses, 2020 The majority of human prion diseases are sporadic, but acquired disease can occur, as seen with variant Creutzfeldt–Jakob disease (vCJD) following consumption of bovine spongiform encephalopathy (BSE).
Satish K. Nemani +4 more
doaj +1 more source
Pathways in Two-State Protein Folding [PDF]
, 1999 The thermodynamics of proteins indicate that folding/unfolding takes place either through stable intermediates or through a two-state process without intermediates.
Alberts +23 more
core +3 more sources
Social context prevents heat hormetic effects against mutagens during fish development
FEBS Letters, EarlyView.This study shows that sublethal heat stress protects fish embryos against ultraviolet radiation, a concept known as ‘hormesis’. However, chemical stress transmission between fish embryos negates this protective effect. By providing evidence for the mechanistic molecular basis of heat stress hormesis and interindividual stress communication, this study ...
Lauric Feugere +5 more
wiley +1 more source
Propagation of PrPSc in mice reveals impact of aggregate composition on prion disease pathogenesis
Communications Biology, 2023 Infectious prions consist of PrPSc, a misfolded, aggregation-prone isoform of the host’s prion protein. PrPSc assemblies encode distinct biochemical and biological properties.
Sheng Chun Chang +6 more
doaj +1 more source
Protein folding rates correlate with heterogeneity of folding mechanism [PDF]
, 2004 By observing trends in the folding kinetics of experimental 2-state proteins at their transition midpoints, and by observing trends in the barrier heights of numerous simulations of coarse grained, C-alpha model, Go proteins, we show that folding rates ...
A. R. Fersht +10 more
core +2 more sources
Managing the protein folding demands in the endoplasmic reticulum of plants.
New Phytologist, 2016 Endoplasmic reticulum (ER) stress occurs in plants during certain developmental stages or under adverse environmental conditions, as a result of the accumulation of unfolded or misfolded proteins in the ER.
Jian-Xiang Liu, S. Howell
semanticscholar +1 more source
miRNA‐29 regulates epidermal and mesenchymal functions in skin repair
FEBS Letters, EarlyView.miRNA‐29 inhibits cell‐to‐cell and cell‐to‐matrix adhesion by silencing mRNA targets. Adhesion is controlled by complex interactions between many types of molecules coded by mRNAs. This is crucial for keeping together the layers of the skin and for regenerating the skin after wounding.
Lalitha Thiagarajan +10 more
wiley +1 more source
Bioengineering & Translational MedicineSynucleinopathies, including Parkinson's disease (PD), multiple system atrophy (MSA), and dementia with Lewy bodies (DLB), are neurodegenerative disorders caused by the accumulation of misfolded alpha‐synuclein protein.
Jose Miguel Flores‐Fernandez +13 more
doaj +1 more source
Macromolecular crowding modulates folding mechanism of alpha/beta protein apoflavodoxin
, 2008 Protein dynamics in cells may be different from that in dilute solutions in vitro since the environment in cells is highly concentrated with other macromolecules.
Ai +62 more
core +2 more sources
Bioscience Reports, 1988 The importance of protein folding in the biosynthesis of proteins is reviewed.
openaire +2 more sources