Results 131 to 140 of about 6,828,531 (409)
Folding of Protein L with implications for collapse in the denatured state ensemble [PDF]
, 2016 A fundamental question in protein folding is whether the coil to globule collapse transition occurs during the initial stages of folding (burst-phase) or simultaneously with the protein folding transition. Single molecule fluorescence resonance energy transfer (FRET) and small angle X-ray scattering (SAXS) experiments disagree on whether Protein L ...
arxiv +1 more source
Two State Behavior in a Solvable Model of $\beta$-hairpin folding
, 1999 Understanding the mechanism of protein secondary structure formation is an essential part of protein-folding puzzle. Here we describe a simple model for the formation of the $\beta$-hairpin, motivated by the fact that folding of a $\beta$-hairpin ...
A. Finkelstein +19 more
core +1 more source
Chaperones and protein folding
Current Opinion in Cell Biology, 1992 Chaperones are centrally involved in the control of protein structure, function, localization and transport. A flurry of scientific activity continues to examine the molecular nature of chaperone-substrate recognition and the role of auxiliary chaperones (cohort proteins) and small molecules that expedite these processes.
Kelley, William, Georgopoulos, C.
openaire +4 more sources
Protein Folding and Mechanisms of Proteostasis
International Journal of Molecular Sciences, 2015 Highly sophisticated mechanisms that modulate protein structure and function, which involve synthesis and degradation, have evolved to maintain cellular homeostasis. Perturbations in these mechanisms can lead to protein dysfunction as well as deleterious
José Fernando Díaz-Villanueva +2 more
semanticscholar +1 more source
Disruption of SETD3‐mediated histidine‐73 methylation by the BWCFF‐associated β‐actin G74S mutation
FEBS Letters, EarlyView.The β‐actin G74S mutation causes altered interaction of actin with SETD3, reducing histidine‐73 methylation efficiency and forming two distinct actin variants. The variable ratio of these variants across cell types and developmental stages contributes to tissue‐specific phenotypical changes. This imbalance may impair actin dynamics and mechanosensitive
Anja Marquardt +8 more
wiley +1 more source
Frontiers in Microbiology, 2019 The application of D-stereospecific proteases (DSPs) in resolution of racemic amino acids and in the semisynthesis of proteins has been a successful strategy.
Andreas H. Simon +4 more
doaj +1 more source
A Conversation on Protein Folding [PDF]
Journal of Biomolecular Structure and Dynamics, 2011 (2011). A Conversation on Protein Folding. Journal of Biomolecular Structure and Dynamics: Vol. 28, No. 4, pp. 587-588.
openaire +3 more sources
Electrostatic Interactions in Protein Structure, Folding, Binding, and Condensation.
Chemical Reviews, 2018 Charged and polar groups, through forming ion pairs, hydrogen bonds, and other less specific electrostatic interactions, impart important properties to proteins.
Huan‐Xiang Zhou, Xiaodong Pang
semanticscholar +1 more source
Molecular Oncology, EarlyView.The number of circulating tumor cells obtained from prostate cancer patients was increased approximately 5‐fold compared to regular CellSearch when processing 2 mL diagnostic leukapheresis material aliquots and increased by 44‐fold when processing 20 mL DLA aliquots using the flow enrichment target capture Halbach‐array.
Michiel Stevens +8 more
wiley +1 more source
Nature Communications, 2016 Small-molecule chaperones that can prevent protein misfolding have potential applications for treating diseases such as Alzheimer’s and ALS. Here the authors use high-resolution force spectroscopy to gain insight into the mechanism of action of an iron ...
Amar Nath Gupta +5 more
doaj +1 more source