Results 81 to 90 of about 932,427 (312)

Function‐driven design of a surrogate interleukin‐2 receptor ligand

FEBS Letters, EarlyView.
Interleukin (IL)‐2 signaling can be achieved and precisely fine‐tuned through the affinity, distance, and orientation of the heterodimeric receptors with their ligands. We designed a biased IL‐2 surrogate ligand that selectively promotes effector T and natural killer cell activation and differentiation. Interleukin (IL) receptors play a pivotal role in
Ziwei Tang, Zelin Cheng, Teng Li, Fulian Wang, Liangminghui Zhang, Xiuxiu He, Lili Liu, Wei Wang, Aibin Liang, Guang Yang   +9 more
wiley   +1 more source

Mitochondrial protein import [PDF]

, 1988
Transport of nuclear-encoded precursor proteins into mitochondria includes proteolytic cleavage of aminoterminal targeting sequences in the mitochondrial matrix. We have isolated the processing activity from Neurospora crassa.
Hartl, Franz-Ulrich, Hawlitschek, Gerhard, Neupert, Walter, Schmidt, Bernd, Schneider, Helmut, Tropschug, Maximilian   +5 more
core   +1 more source

Time after time – circadian clocks through the lens of oscillator theory

FEBS Letters, EarlyView.
Oscillator theory bridges physics and circadian biology. Damped oscillators require external drivers, while limit cycles emerge from delayed feedback and nonlinearities. Coupling enables tissue‐level coherence, and entrainment aligns internal clocks with environmental cues.
Marta del Olmo, Carolin Ector, Hanspeter Herzel   +2 more
wiley   +1 more source

Determination of green forage and silage protein degradability of some pea (Pisum sativum L.) + oat (Avena sativa L.) mixtures grown in Serbia

Journal of Agricultural Sciences, 2017
This research was conducted to detrmine the effect of seeed rates in mixtures of Pea + Oat on the green forage and silage proein fractions by Cornell Net Carbohydrate and Protein System (CNCPS).
Milomir Blagojević, Nenad đorđević, Bora D, Jordan Marković, Tanja Vasić, Jamina Milenković, Mirjana Petrović   +6 more
doaj   +1 more source

The plasma proteins and their fractionation [PDF]

Ergebnisse der Physiologie Biologischen Chemie und Experimentellen Pharmakologie, 1947
The large scale fractionation of the pro teins of blood plasma was direct1y a product of the needs of military medicine in the United States during the war. Fundamentally, however, this development rests on a long series of advances in protein chemistry which have occurred over the last forty years in many laboratories, notably in England, Scandinavia,
openaire   +2 more sources

Ethanol Induced Disordering of Pancreatic Acinar Cell Endoplasmic Reticulum: An ER Stress/Defective Unfolded Protein Response Model. [PDF]

, 2018
Background & aimsHeavy alcohol drinking is associated with pancreatitis, whereas moderate intake lowers the risk. Mice fed ethanol long term show no pancreas damage unless adaptive/protective responses mediating proteostasis are disrupted. Pancreatic
Abrol, Ravinder, Capri, Joseph, Cohn, Whitaker, Faull, Kym F, Freeman, Michael R, Lugea, Aurelia, Pandol, Stephen J, Piplani, Honit, Sakkiah, Sugunadevi, Su, Hsin-Yuan, Waldron, Richard T, Whitelegge, Julian P, Yang, Wei, Zhou, Bo   +13 more
core   +3 more sources

Multiple ETS family transcription factors bind mutant p53 via distinct interaction regions

FEBS Letters, EarlyView.
Mutant p53 gain‐of‐function is thought to be mediated by interaction with other transcription factors. We identify multiple ETS transcription factors that can bind mutant p53 and found that this interaction can be promoted by a PXXPP motif. ETS proteins that strongly bound mutant p53 were upregulated in ovarian cancer compared to ETS proteins that ...
Stephanie A. Metcalf, Nicholas F. Downing, Kaitlyn M. Mills, Samuel C. Metcalfe, Alexander E. Kritzer, Lindsey D. Mayo, Peter C. Hollenhorst   +6 more
wiley   +1 more source

ACTIVITY OF TUBERCULOSIS WHEN CALCIFICATION IS DETECTED IN THE CHEST LYMPH NODES AND LUNGS OF CHILDREN

Туберкулез и болезни лёгких, 2017
Introduction of new examination techniques to tuberculosis control in children resulted in the increase of Group IIIA of the dispensary follow-up.Goal: to define criteria of tuberculosis disease activity when calcification is detected in the chest lymph ...
A. V. Mezentseva, T. E. Tyulkova, Yu. P. Chugaev, N. G. Kamaeva, I. A. Dolmatova   +4 more
doaj   +1 more source

Immunochemical studies on human plasma lipoproteins [PDF]

, 1957
Some years ago, a series of human serum lipoproteins, distinguishable by their hydrated densities and lipid-protein ratios were recognized and isolated by ultracentrifugal techniques (1).
Aladjem, Frederick, Gofman, W., Lieberman, Miriam   +2 more
core   +1 more source

The newfound relationship between extrachromosomal DNAs and excised signal circles

FEBS Letters, EarlyView.
Extrachromosomal DNAs (ecDNAs) contribute to the progression of many human cancers. In addition, circular DNA by‐products of V(D)J recombination, excised signal circles (ESCs), have roles in cancer progression but have largely been overlooked. In this Review, we explore the roles of ecDNAs and ESCs in cancer development, and highlight why these ...
Dylan Casey, Zeqian Gao, Joan Boyes
wiley   +1 more source