Results 141 to 150 of about 608,807 (260)

Novel Protein Kinase Inhibitors: SMART Drug Design Technology

BioTechniques, 2003
Tomi K. Sawyer, Regine S. Bohacek, Chester A. Metcalf III, William C. Shakespeare, Yihan Wang, Raji Sundaramoorthi, Terence Keenan, Surinder Narula, Manfred Weigele, David C. Dalgarno   +9 more
doaj   +1 more source

Views of European Union medicine regulators and healthcare professionals on the approved versus prescribed dose of protein kinase inhibitors: an interview study. [PDF]

BMJ Open
Brinkhof M, de Vries ST, Mol PGM, Trapani D, Marije de Jong I, Broekman KE.   +5 more
europepmc   +1 more source

Reported hepatotoxicity and hepatotoxicity guidance in the product information of protein kinase inhibitors in oncology registered at the European Medicines Agency. [PDF]

Pharmacol Res Perspect, 2023
Maliepaard M, Faber YS, van Bussel MTJ.
europepmc   +1 more source

Pharmacological inhibition of the PERK pathway modulates hepatocellular carcinoma growth and immune signaling

FEBS Open Bio, EarlyView.
Pharmacological inhibition of PERK in a DEN‐induced mouse model of liver cancer does not reduce tumor burden but alters cellular stress signaling. Despite blocking PERK activity, downstream stress responses, including CHOP expression, remain active, suggesting compensatory mechanisms within the unfolded protein response that may influence tumor ...
Ada Lerma‐Clavero, Maria Kopsida, Nathalie Arendt, Hans Lennernäs, Markus Sjöblom, Femke Heindryckx   +5 more
wiley   +1 more source

Targeting Neuroinflammation and Cognitive Decline: First-in-Class Dual Butyrylcholinesterase and p38α Mitogen-Activated Protein Kinase Inhibitors. [PDF]

J Med Chem
Ferjančič Benetik S, Proj M, Knez D, Košak U, Meden A, Krajšek K, Pišlar A, Horvat S, Švajger U, Tešić N, Pulkrabkova L, Soukup O, Skarka A, Andrys R, Brazzolotto X, Igert A, Nachon F, Dias J, Detka J, Gdula-Argasińska J, Wyska E, Szafarz M, Manik A, Płachtij N, Musílek K, Sałat K, Obreza A, Gobec S.   +27 more
europepmc   +1 more source

Development and Evolution of DNA-Dependent Protein Kinase Inhibitors toward Cancer Therapy. [PDF]

Int J Mol Sci, 2022
Matsumoto Y.
europepmc   +1 more source

Sudden anaerobization in Amphibacillus xylanus increases intracellular labile ferrous iron and inhibits cell growth

FEBS Open Bio, EarlyView.
Abruptly changing from aerobic to anaerobic conditions (sudden anaerobization) induced growth inhibition and a significant increase in intracellular labile ferrous iron in the aerotolerant anaerobe Amphibacillus xylanus. We found that free flavins mediate efficient electron transfer from NADH to ferric iron under anaerobic conditions, suggesting that ...
Shinya Kimata, Yoichi Sakai, Keisuke Tanaka, Etsuro Yoshimura, Ken Kitano, Morio Ishikawa, Tadahiro Nakamoto, Tsutomu Takayama, Hirofumi Inoue, Kaho Nomura, Tomonori Suzuki, Masataka Uchino, Akira Abe, Youichi Niimura   +13 more
wiley   +1 more source

Advances in pyrazolo[1,5-a]pyrimidines: synthesis and their role as protein kinase inhibitors in cancer treatment. [PDF]

RSC Adv
Iorkula TH, Jude-Kelly Osayawe O, Odogwu DA, Ganiyu LO, Faderin E, Awoyemi RF, Akodu BO, Ifijen IH, Aworinde OR, Agyemang P, Onyinyechi OL.   +10 more
europepmc   +1 more source

Synthesis of 2-Oxoquinoline Derivatives as Dual Pim and mTORC Protein Kinase Inhibitors. [PDF]

Med Chem Res, 2022
Gnawali GR, Okumura K, Perez K, Gallagher R, Wulfkuhle J, Petricoin EF, Padi SKR, Bearss J, He Z, Wang W, Kraft AS.   +10 more
europepmc   +1 more source

Cyclic azapeptide CD36 ligand attenuates cardiac injury and reduces long‐chain fatty acid accumulation after myocardial ischemia–reperfusion in mice

FEBS Open Bio, EarlyView.
In a murine model of myocardial ischemia and reperfusion (MI/R), the CD36 azapeptide ligand MPE‐298 reduces cardiac injury and transiently lowers left ventricular long‐chain fatty acids (LCFAs) accumulation 3 h after reperfusion, accompanied by a decrease of oxidative stress and inflammation‐associated genes' expression in the heart and adipose tissue.
Jade Gauvin, Naghme Radmannia, David N. Huynh, Liliane Ménard, Caroline Daneault, Maïté Veilleux, Ahsanullah Ahsanullah, André C. Carpentier, William D. Lubell, Matthieu Ruiz, Huy Ong, Sylvie Marleau, Simon‐Pierre Gravel   +12 more
wiley   +1 more source