Results 211 to 220 of about 875,741 (363)

Classification of Calcium-Dependent Protein Kinases and Their Transcriptional Response to Abiotic Stresses in Halophyte <i>Nitraria sibirica</i>. [PDF]

Plants (Basel)
Lu L, Chen T, Yang T, Han C, Zhang J, Chen J, Cheng T.   +6 more
europepmc   +1 more source

Lactoferrin treatment activates acetylcholinesterase, decreasing acetylcholine levels in non‐small cell lung cancer (NSCLC) cell culture supernatants, inhibiting cell survival

FEBS Open Bio, EarlyView.
Representation of the suggested mode of action of lactoferrin (Lf) in nonsmall cell lung cancer (NSCLC) A549 cells. Lf induces activation of caspase‐3 by activating p53 and AChE leading to decreased ACh concentrations. In turn, ACh signaling leads to activation of VEGF and AKT and blocking of caspase‐3.
Stuti Goel, Caroline Wozniak, Aya Sabri, Ben Haddad, Brooke Lopo, Alvaro Cobos, Sarah Sarofim, Jeffrey Guthrie, Deborah Heyl, Hedeel Guy Evans   +9 more
wiley   +1 more source

Targeting JNK1/2 and P38 Mitogen-Activated Protein Kinases With Pazopanib Mitigates Bleomycin-Induced Lung Fibrosis. [PDF]

Arch Pharm (Weinheim)
Abdelhady R, Sayed RH, Younis NS, Ali O, Elhemely MA, Ashour AM, Alsufyani SE, Arab HH, Abdel-Hamid MS.   +8 more
europepmc   +1 more source

Mitogen-Activated Protein Kinase Kinase Kinase Kinase 3 [PDF]

, 2020
openaire   +1 more source

Differentiation of HL-60 leukemia by type I regulatory subunit antisense oligodeoxynucleotide of cAMP-dependent protein kinase.

, 1991
Giampaolo Tortora, Hiroshi Yokozaki, Stefano Pepe, Timothy Clair, Yoon S. Cho‐Chung   +4 more
openalex   +2 more sources

Indoleamine 2,3‐dioxygenase 1 inhibition reverses cancer‐associated fibroblast‐mediated immunosuppression in high‐grade serous ovarian cancer

FEBS Open Bio, EarlyView.
CAF‐mediated immunosuppression in ovarian cancer is driven by IDO1, reducing T‐cell function. Inhibiting IDO1 restores T‐cell proliferation and cytotoxicity, increases cancer cell apoptosis, and may help overcome CAF‐induced immune suppression in high‐grade serous ovarian cancer. Targeting IDO1 may improve antitumor immunity.
Hyewon Lee, Jung Yoon Ho, In Sun Hwang, Youn Jin Choi   +3 more
wiley   +1 more source

Water-Based Pharmacophore Modeling in Kinase Inhibitor Design: A Case Study on Fyn and Lyn Protein Kinases. [PDF]

J Chem Inf Model
Ljubič M, Sollner Dolenc M, Borišek J, Perdih A.   +3 more
europepmc   +1 more source

Novel yeast protein kinase (YPK1 gene product) is a 40-kilodalton phosphotyrosyl protein associated with protein-tyrosine kinase activity.

, 1990
David Dailey, Gary L. Schieven, Moon Young Lim, Hans Marquardt, Thomas D. Gilmore, Jeremy Thorner, Greg S. Martin   +6 more
openalex   +2 more sources

Overexpression of CDT1 inhibits cell cycle progression at S phase by interacting with the mini‐chromosome maintenance complex and causes DNA damage

FEBS Open Bio, EarlyView.
CDT1 is an essential protein for DNA replication licensing that loads the MCM complex, the eukaryotic replicative DNA helicase, onto replication origins. Overexpression of CDT1 induces cell cycle arrest at the S phase. Here we showed CDT1 inhibits the progression of replication forks by interacting with the MCM complex, leading to the stalling and ...
Takashi Tsuyama, Nonoka Takayama, Rina Tanaka, Yuuki Arai, Yohko Yamaguchi, Yuko Nawata, Yutaro Azuma, Shusuke Tada   +7 more
wiley   +1 more source

Protein kinases in neurodegenerative diseases: current understandings and implications for drug discovery. [PDF]

Signal Transduct Target Ther
Wu X, Yang Z, Zou J, Gao H, Shao Z, Li C, Lei P.   +6 more
europepmc   +1 more source