Results 251 to 260 of about 875,741 (363)

Pathogenic Neurofibromatosis type 1 gene variants in tumors of non‐NF1 patients and role of R1276

FEBS Open Bio, EarlyView.
Somatic variants of the neurofibromatosis type 1 (NF1) gene occur across neoplasms without clinical manifestation of the disease NF1. We identified emerging somatic pathogenic NF1 variants and hotspots, for example, at the arginine finger 1276. Those missense variants provide fundamental information about neurofibromin's role in cancer.
Mareike Selig, Swanhild Lohse, Sara Elahi, Nils Hartmann, Stefanie Deckert, Shutian Si, Alexander Desuki, Anja Harder   +7 more
wiley   +1 more source

Histidine Phosphorylation: Protein Kinases and Phosphatases. [PDF]

Int J Mol Sci
Ning J, Sala M, Reina J, Kalagiri R, Hunter T, McCullough BS.   +5 more
europepmc   +1 more source

Mitogen-activated protein kinase kinase kinase kinase 3 (MAP4K3) [PDF]

Science-Business eXchange, 2009
openaire   +1 more source

Down‐regulation of Shh in the hair follicles of mice during chemotherapy‐induced hair loss is mediated by the JAK/STAT1 signaling pathway

FEBS Open Bio, EarlyView.
We found that during chemotherapy‐induced alopecia (CIA), Sonic hedgehog (Shh) expression significantly decreased in hair follicle Shh+ cells, whereas the Janus‐activated kinase/signal transducer and activator of transcription 1 (JAK/STAT1) signaling pathway was markedly activated.
Ruifang Fan, Jingling Huang, Xiang Lin, Tingjiao Lan, Yuli Tang, Ling Sun, Guixuan Zhou   +6 more
wiley   +1 more source

KiNext: a portable and scalable workflow for the identification and classification of protein kinases. [PDF]

BMC Bioinformatics
Hellec E, Nunes F, Corporeau C, Cormier A.   +3 more
europepmc   +1 more source

Mitogen-Activated Protein Kinase Kinase Kinase 4 [PDF]

, 2020
openaire   +1 more source

Role of mitogen activated protein kinase in the regulation of the voltage-dependent sodium channels in adrenal chromaffin cells.

, 1999
Toshihiko Yanagita, Hideyuki Kobayashi, Ryuichi Yamamoto, Keizou Masumoto, Hiroki Yokoo, Seiji Shiraishi, Shin‐ichi Minami, Akihiko Wada   +7 more
openalex   +1 more source

SIRT4 positively regulates autophagy via ULK1, but independently of HDAC6 and OPA1

FEBS Open Bio, EarlyView.
Cells expressing SIRT4 (H161Y), a catalytically inactive mutant of the sirtuin SIRT4, fail to upregulate LC3B‐II and exhibit a reduced autophagic flux under stress conditions. Interestingly, SIRT4(H161Y) promotes phosphorylation of ULK1 at S638 and S758 that are associated with inhibition of autophagy initiation.
Isabell Lehmkuhl, Khawar Amin, Lydia Gabriel, Nils Hampel, Afshin Iram, Julia Hesse, Constanze Wiek, Jasmin Thuy Vy Nguyen, Helmut Hanenberg, Jürgen Scheller, M. Reza Ahmadian, Björn Stork, Doreen M. Floss, Roland P. Piekorz   +13 more
wiley   +1 more source

Cyclin-dependent protein kinases and cell cycle regulation in biology and disease. [PDF]

Signal Transduct Target Ther
Pellarin I, Dall'Acqua A, Favero A, Segatto I, Rossi V, Crestan N, Karimbayli J, Belletti B, Baldassarre G.   +8 more
europepmc   +1 more source