Results 251 to 260 of about 856,952 (362)

Overview of molecular signatures of senescence and associated resources: pros and cons

FEBS Open Bio, EarlyView.
Cells can enter a stress response state termed cellular senescence that is involved in various diseases and aging. Detecting these cells is challenging due to the lack of universal biomarkers. This review presents the current state of senescence identification, from biomarkers to molecular signatures, compares tools and approaches, and highlights ...
Orestis A. Ntintas, Sylvia Vagena, Pavlos Pantelis, Giorgos Theocharous, Russel Petty, Konstantinos Evangelou, Vassilis G. Gorgoulis   +6 more
wiley   +1 more source

Cyclin-dependent protein kinases and cell cycle regulation in biology and disease. [PDF]

Signal Transduct Target Ther
Pellarin I, Dall'Acqua A, Favero A, Segatto I, Rossi V, Crestan N, Karimbayli J, Belletti B, Baldassarre G.   +8 more
europepmc   +1 more source

Cyclic Adenosine 3′:5′-Monophosphate-dependent Protein Kinase

, 1973
Francis A. Neelon, Bruce M. Birch
openalex   +1 more source

Molecular determinants of signal transduction in tropomyosin receptor kinases

FEBS Open Bio, EarlyView.
Tropomyosin receptor kinases control critical neuronal functions, but how do the same receptors produce diverse cellular responses? This review explores the structural mechanisms behind Trk signaling diversity, focusing on allosteric modulation and ligand bias.
Giray Enkavi
wiley   +1 more source

KiNext: a portable and scalable workflow for the identification and classification of protein kinases. [PDF]

BMC Bioinformatics
Hellec E, Nunes F, Corporeau C, Cormier A.   +3 more
europepmc   +1 more source

Hormonally specific expression of cardiac protein kinase activity [PDF]

, 1979
J S Hayes, Laurence L. Brunton, Joan Heller Brown, James B. Reese, Steven E. Mayer   +4 more
openalex   +1 more source

ATG4B is required for mTORC1‐mediated anabolic activity and is associated with clinical outcomes in non‐small cell lung cancer

FEBS Open Bio, EarlyView.
The relationship between anabolic and catabolic processes governing lung cancer cell growth is nuanced. We show that ATG4B, an autophagy regulator, is elevated in lung cancer and that high ATG4B is associated with worse patient outcomes. Targeting ATG4B in cells reduces growth, protein synthesis, and mTORC1 activity, demonstrating a new relationship ...
Patrick J. Ryan, Bethany C. Guerra, Selina Uranga, Jessica M. Cardin, Steven E. Riechman, Mariana Janini Gomes, James D. Fluckey   +6 more
wiley   +1 more source

Histidine Phosphorylation: Protein Kinases and Phosphatases. [PDF]

Int J Mol Sci
Ning J, Sala M, Reina J, Kalagiri R, Hunter T, McCullough BS.   +5 more
europepmc   +1 more source

A chemical-genetic approach to elucidate protein kinase function in planta [PDF]

, 2007
Böhmer, M., Romeis, T.
core   +1 more source

Research progress on the metabolic transformation of Shenling Baizhu San under the influence of the gut microbiota

Advanced Chinese Medicine, EarlyView.
Abstract The gut microbiota plays a pivotal role in maintaining host metabolic homeostasis and overall physiological functions. Shenling Baizhu San (SLBZS), a time‐honored classical prescription for tonifying Qi, strengthening the spleen, removing dampness, and arresting diarrhea, has shown broad clinical efficacy in digestive disorders.
Jinlan Di, Xiaochun Zhang
wiley   +1 more source