Results 261 to 270 of about 6,819,213 (411)

A new protein containing an SH2 domain that inhibits JAK kinases

Nature, 1997
T. Endo, M. Masuhara, M. Yokouchi, R. Suzuki, H. Sakamoto, Kaoru Mitsui, A. Matsumoto, Shyu Tanimura, M. Ohtsubo, H. Misawa, T. Miyazaki, N. Leonor, T. Taniguchi, T. Fujita, Y. Kanakura, S. Komiya, A. Yoshimura   +16 more
semanticscholar   +1 more source

Establishment of a coculture system for Porphyromonas gingivalis and head and neck squamous cell carcinoma using spheroid culture and LATS inhibition

FEBS Open Bio, EarlyView.
We established a spheroid coculture system enabling viable Porphyromonas gingivalis–HNSCC interactions under normoxic conditions. Inhibition of LATS1/2 maintains tumor cells in an undifferentiated state, which may promote spheroid growth and create a more permissive environment for bacterial persistence.
Yurika Nakajima, Shogo Okazaki, Muneaki Tamura, Shuichi Sato, Kenichi Imai   +4 more
wiley   +1 more source

Water-Based Pharmacophore Modeling in Kinase Inhibitor Design: A Case Study on Fyn and Lyn Protein Kinases. [PDF]

J Chem Inf Model
Ljubič M, Sollner Dolenc M, Borišek J, Perdih A.   +3 more
europepmc   +1 more source

Computational analysis of regulatory regions in human protein kinases. [PDF]

Protein Sci, 2023
Pei J, Cong Q.
europepmc   +1 more source

Arecoline inhibits the growth of 3T3-L1 preadipocytes via AMP-activated protein kinase and reactive oxygen species pathways

, 2018
Zi-Han Tian, Jueng-Tsueng Weng, Li‐Jane Shih, An-Ci Siao, Tsai-Yun Chan, Yi-Wei Tsuei, Yow-Chii Kuo, Tsu-Shing Wang, Yung-Hsi Kao   +8 more
openalex   +2 more sources

Supplementary Figure 2 from Heat Shock Protein B8, a Cyclin-Dependent Kinase–Independent Cyclin D1 Target Gene, Contributes to Its Effects on Radiation Sensitivity

, 2023
Sally Trent, Chuanwei Yang, Cuiqi Li, Mary Lynch, Emmett V. Schmidt   +4 more
openalex   +1 more source

Pathogenic Neurofibromatosis type 1 gene variants in tumors of non‐NF1 patients and role of R1276

FEBS Open Bio, EarlyView.
Somatic variants of the neurofibromatosis type 1 (NF1) gene occur across neoplasms without clinical manifestation of the disease NF1. We identified emerging somatic pathogenic NF1 variants and hotspots, for example, at the arginine finger 1276. Those missense variants provide fundamental information about neurofibromin's role in cancer.
Mareike Selig, Swanhild Lohse, Sara Elahi, Nils Hartmann, Stefanie Deckert, Shutian Si, Alexander Desuki, Anja Harder   +7 more
wiley   +1 more source

Protein kinases in neurodegenerative diseases: current understandings and implications for drug discovery. [PDF]

Signal Transduct Target Ther
Wu X, Yang Z, Zou J, Gao H, Shao Z, Li C, Lei P.   +6 more
europepmc   +1 more source

A chemical-genetic approach to elucidate protein kinase function in planta [PDF]

, 2007
Böhmer, M., Romeis, T.
core   +1 more source

Heparin inhibits mitogen-activated protein kinase activation in intact rat vascular smooth muscle cells.

, 1993
Michael E. Ottlinger, Laurie Pukac, Morris J. Karnovsky   +2 more
openalex   +1 more source