Results 101 to 110 of about 11,155,248 (357)

Determination of Cellular Phosphatidylinositol-3-phosphate (PI3P) Levels Using a Fluorescently Labelled Selective PI3P Binding Domain (PX)

Bio-Protocol, 2016
The lipid Phosphatidylinositol-3-phosphate [PtdIns3P or PI(3)P] plays many membrane trafficking roles and is primarily produced by the Class III PI3K, VPS34. Determining the level of cellular PI(3)P however can be complex.
Michael Munson, Ian Ganley
doaj   +1 more source

14-3-3 Proteins Interact with a Hybrid Prenyl-Phosphorylation Motif to Inhibit G Proteins [PDF]

, 2013
Signaling through G proteins normally involves conformational switching between GTP- and GDP-bound states. Several Rho GTPases are also regulated by RhoGDI binding and sequestering in the cytosol.
Riou, P, Parker, Peter J., O’Reilly, N., George, Roger, Ritu Garg, McColl, Brad, Ganka Bineva, Kjær, S., Svend Kjær, Garg, R, Bineva, G., Thompson, AJ, Reymond, N, Thompson, Andrew J., Philippe Riou, Purkiss, Andrew, Nicola O’Reilly, Parker, Peter J, Brad McColl, Peter J. Parker, Neil Q. McDonald, Parker, Peter J.; id_orcid, O’Reilly, Nicola, Riou, P., Purkiss, A, Parker, PJ, Thompson, A.J., McColl, B, Cain, RJ, Parker, P.J., Kjær, Svend, McColl, B., Andrew Purkiss, O’Reilly, N, Kjær, S, Garg, R., Garg, Ritu, O'Reilly, Nicola, Anne J. Ridley, Cain, Robert J, Robert J. Cain, McDonald, Neil Q, Ridley, Anne J, Bineva, G, Ridley, A.J., Purkiss, Andrew G., Nicolas Reymond, George, R., Thompson, Andrew J, Reymond, N., Reymond, Nicolas, Cain, Robert J., Bineva, Ganka, McDonald, NQ, Riou, Philippe, Andrew J. Thompson, Ridley, AJ, Kjaer, Svend, George, R, Cain, R.J., Ridley, Anne J., Roger George, McDonald, Neil Q.   +62 more
core   +1 more source

The Shewanella oneidensis Fic enzyme SoFic targets the switch‐I region of EF‐Tu for AMPylation

FEBS Letters, EarlyView.
Fic enzymes mediate diverse post‐translational modifications across all domains of life, including AMPylation. Prokaryotic EF‐Tu can be AMPylated and deAMPylated by the conserved Fic enzyme SoFic. Structural and biochemical approaches were used to characterize the effect of AMPylation on EF‐Tu, SoFic's enzymatic activities, and the enzyme‐target ...
Svenja Runge, Vivian Pogenberg, Alexander Baumgart, Bente Siebels, Hartmut Schlüter, Michael Hecht‐Bucher, Aymelt Itzen   +6 more
wiley   +1 more source

Localization-Dependent and -Independent Roles of SLX4 in Regulating Telomeres

Cell Reports, 2013
SLX4, a scaffold for structure-specific DNA repair nucleases, is important for several types of DNA repair. Many repair proteins bind to sites of DNA damage, resulting in subnuclear “foci,” but SLX4 forms foci in human cells even without DNA damage ...
Jamie S.J. Wilson, Agueda M. Tejera, Dennis Castor, Rachel Toth, Maria A. Blasco, John Rouse   +5 more
doaj   +1 more source

Pro-inflammatory Cytokines and Environmental Stress Cause p38 Mitogen-activated Protein Kinase Activation by Dual Phosphorylation on Tyrosine and Threonine (*)

Journal of Biological Chemistry, 1995
Protein kinases activated by dual phosphorylation on Tyr and Thr (MAP kinases) can be grouped into two major classes: ERK and JNK. The ERK group regulates multiple targets in response to growth factors via a Ras-dependent mechanism.
J. Raingeaud, Shashi Gupta, J. S. Rogers, M. Dickens, Jiahuai Han, R. Ulevitch, R. Davis   +6 more
semanticscholar   +1 more source

Phosphorylation of the actin binding protein Drebrin at S647 and is regulated by neuronal activity and PTEN [PDF]

, 2013
Defects in actin dynamics affect activity-dependent modulation of synaptic transmission and neuronal plasticity, and can cause cognitive impairment. A salient candidate actin-binding protein linking synaptic dysfunction to cognitive deficits is Drebrin ...
Rita Hendricusdottir, Louise Kay, Harwood, Adrian, Ismini E Papageorgiou, Britta J Eickholt, Harwood, Adrian John, Leslie, Nicholas R; id_orcid, van Diepen, Michael, Leslie, Nicholas R, Parsons, Madeline; id_orcid, Kreis, Patricia, Leslie, Nicholas R., Nicholas R Leslie, Kann, Oliver, Michiel van Diepen, Papageorgiou, Ismini E, Adrian Harwood, Patricia Kreis, Parsons, Maddy, Till Mack, Fox, Michael A., Kay, Louise, van Diepen, Michiel, Oliver Kann, Mack, Till, Papageorgiou, Ismini E., Hendricusdottir, Rita, Maddy Parsons, Ryves, Jonny, Jonny Ryves, Eickholt, Britta J., Eickholt, Britta J   +31 more
core   +1 more source

A context‐dependent modulatory role for eIF6 in acquired resistance to vemurafenib in melanoma

FEBS Letters, EarlyView.
Acquired resistance to vemurafenib upregulates the translation factor eIF6 in melanoma cells. Silencing eIF6 in resistant cells reduces proliferation and partially restores drug sensitivity, whereas its overexpression increases sensitivity across melanoma lines regardless of BRAF status, via modulation of mTOR, S6K, and MAPK signaling.
George Kyriakopoulos, Antonia Petropoulou, Alexandra Anastogianni, Angelina Bania, Vassilis Stamatakis, Argyris Alexiou, Chi‐Ping Day, Glenn Merlino, Katerina Grafanaki, Constantinos Stathopoulos   +9 more
wiley   +1 more source

USP5 acts as a proteolytic switch to control SDE2 function via UBL-directed cleavage

Nature Communications
Proteolytic processing is a fundamental regulatory mechanism in eukaryotic cells, yet the molecular identities and mechanisms underlying such events are often poorly defined. Silencing Defective 2 (SDE2), an essential human protein, plays important roles
Liam T. Hales, Paul M. Tammiste, Adam J. Walker, Rebecca Bryce, Andrew Sugden, Axel Knebel, Rachel Toth, Frédéric Lamoliatte, Marian Péteri, Oliwia Curry, Glenn R. Masson, Virginia De Cesare, Chiara Maniaci   +12 more
doaj   +1 more source

AMPK and mTOR regulate autophagy through direct phosphorylation of Ulk1

Nature Cell Biology, 2011
Autophagy is a process by which components of the cell are degraded to maintain essential activity and viability in response to nutrient limitation.
Joungmok Kim, M. Kundu, B. Viollet, K. Guan   +3 more
semanticscholar   +1 more source

A conserved phosphorylation site regulates the transcriptional function of ETHYLENE-INSENSITIVE3-like1 in tomato [PDF]

, 2011
ETHYLENE-INSENSITIVE3/ETHYLENE-INSENSITIVE3-like (EIN3/EIL) transcription factors are important downstream components of the ethylene transduction pathway known to regulate the transcription of early ethylene-responsive genes in plants.
Z. Li, J. Li, Li, Zhengguo, M. Bouzayen, Tang, Ling, M. Zouine, L. Tang, Zouine, Mohamed, Y. Yang, Yang, Yingwu, Li, Ji, Bouzayen, Mondher   +11 more
core   +1 more source