Results 221 to 230 of about 11,155,248 (357)

Missense variant in TTBK2 kinase domain causes loss of function and impaired protein phosphorylation. [PDF]

Sci Rep
Felício D, Osório H, Pereira C, Brandão AF, Freixo JP, Carvalho I, Sousa AP, Castro-Caldas M, Sequeiros J, Lemos C, Santos M.   +10 more
europepmc   +1 more source

Engineered Nanoplatforms Targeting Activated Hepatic Stellate Cells for Liver Fibrosis Therapy via TGF‐β Axis Inhibition and Ferroptosis Induction

Advanced Healthcare Materials, EarlyView.
FeS‐VA@lanifibranor (FVL), an activated hepatic stellate cell (aHSC)‐targeted nanoplatform comprising vitamin A‐functionalized two‐dimensional iron sulfide nanosheets and lanifibranor, is engineered for precision therapy of liver fibrosis. FVL suppresses the TGF‐β signaling pathway by inhibiting SMAD2/3 phosphorylation and induces ferroptosis in aHSCs,
Yinuo Yang, Mengyao Mu, Ke Ren, Hui Liu, Pengju Ma, Yingqi Wang, Mengmeng Zhang, Xueli Xu, Wenzhe Li, Wenshuang Gao, Xiao Sun, Qiang Zhu   +11 more
wiley   +1 more source

Multimodal knowledge expansion widget powered by plant protein phosphorylation database and ChatGPT. [PDF]

Front Bioinform
Xu C, Yu Y, Khadakkar G, Xie J, Xu D, Yao Q.   +5 more
europepmc   +1 more source

Optical Detection of Cellular Signals at Material Interfaces

Advanced Healthcare Materials, EarlyView.
Emerging functional materials are transforming optical detection of cellular signals. This review highlights optical techniques that exploit the unique optical properties of diverse materials to detect and quantify cellular electrical, chemical, and mechanical signals, and discusses key opportunities and challenges.
Xuchen Ren, Jitong Ren, Zixin Zhang, Koney Eungkon Kim, Francis L. Hong, Yuecheng Peter Zhou   +5 more
wiley   +1 more source

Protein phosphorylation networks in Baylisascaris procyonis revealed by phosphoproteomic analysis. [PDF]

Parasit Vectors
Meng Q, Li Z, Qiu Q, Chen S, Gong H, Tan X, Liu X, Chen Z, Liu W.   +8 more
europepmc   +1 more source

AMP-activated protein kinase (AMPK) action in skeletal muscle via direct phosphorylation of PGC-1α

Proceedings of the National Academy of Sciences of the United States of America, 2007
Sibylle Jäger, Christoph Handschin, J. St-Pierre, B. Spiegelman   +3 more
semanticscholar   +1 more source

Blood–Brain Barrier Regulation: Evolving From Classic Strategies to Electrochemical Ion and Reactive Oxygen Species Control

Advanced Healthcare Materials, EarlyView.
Conventional therapies suffer from poor blood–brain barrier (BBB) penetration and disordered ion/reactive oxygen species (ROS) homeostasis, hindering precise neurological treatment. Electrochemical strategies achieve accurate spatiotemporal regulation of neural homeostasis.
Xiaokang Hu, Caiyu Liu, Meijun Pang, Zhiyuan Shi, Dong Ming, Xiuyun Liu   +5 more
wiley   +1 more source

Protocol to quantify protein phosphorylation in mouse extended pluripotent stem cell-derived blastoids. [PDF]

STAR Protoc
Xiao T, Luo Y, Yu Y.
europepmc   +1 more source

The Bacterial Phosphoenolpyruvate:Carbohydrate Phosphotransferase System: Regulation by Protein Phosphorylation and Phosphorylation-Dependent Protein-Protein Interactions

Microbiology and Molecular Reviews, 2014
J. Deutscher, F. Aké, M. Derkaoui, A. Zebre, Thanh Nguyen Cao, H. Bouraoui, Takfarinas Kentache, Abdelhamid Mokhtari, E. Milohanic, P. Joyet   +9 more
semanticscholar   +1 more source

PLL‐g‐HPA Hydrogel Microneedles Loaded With Rhoifolin Target Macrophages to Alleviate Fibroblast Senescence for Diabetic Wound Healing

Advanced Healthcare Materials, EarlyView.
Diabetic wound healing is hindered by a pathological crosstalk wherein elevated IL‐11 induces M1 macrophage polarization, leading to IL‐1β/IL‐6 release and subsequent fibroblast senescence via RAS/p38MAPK/p53/E2F1 signaling. Here, we develop a Gel@M‐Rho microneedle patch that delivers rhoifolin‐loaded, macrophage membrane‐coated nanoparticles to target
Jiewen Liao, Lin Gan, Li Lu, Lizhi Ouyang, Yuan Xiong, Fawwaz Al‐Smadi, Guandong Dai, Mohammad‐Ali Shahbazi, Bobin Mi, Mengfei Liu, Guohui Liu   +10 more
wiley   +1 more source