Results 281 to 290 of about 11,155,248 (357)

Protein phosphorylation and oxidative protein modification promote plant photosystem II disassembly for repair. [PDF]

Plant Commun
McKenzie SD, Puthiyaveetil S.
europepmc   +1 more source

Microglial Deubiquitinase OTUD7B Stabilizes STAT3 to Promote Neuroinflammation and Cognitive Decline in Alzheimer's Disease

Advanced Science, EarlyView.
. ABSTRACT Neuroinflammation driven by microglial activation is a defining feature of Alzheimer's disease (AD), yet the molecular mechanisms sustaining this proinflammatory state remain unclear. Here, we identify the deubiquitinase OTUD7B as a critical regulator of microglial activation and AD pathology.
Luyao Li, Hao Tang, Qin Yu, Yuyang Zhang, Binglu Shi, Ying Kong, Leiyu Xu, Jingjing Shao, Chenghong Hu, Lingyu She, Zhe Wang, Haiyi Chen, Aleksandr V. Samorodov, Gang Cao, Xia Zhao, Yi Wang   +15 more
wiley   +1 more source

NEK10 kinase ablation affects mitochondrial morphology, function and protein phosphorylation status. [PDF]

Proteome Sci
de Oliveira AP, Navarro CDC, Dias PRF, Arguello T, Walker BR, Bacman SR, Sousa LM, Castilho RF, Consonni SR, Moraes CT, Kobarg J.   +10 more
europepmc   +1 more source

TOLLIP Inhibits Psoriasis Progression via Suppressing PKM2‐Mediated Glycolysis in Keratinocytes

Advanced Science, EarlyView.
In this study, we identify TOLLIP as a critical regulator of psoriasis pathogenesis through its modulation of glycolytic metabolism. Our findings establish the TOLLIP‐PKM2‐glycolysis axis as a key mechanism linking metabolic reprogramming to psoriasis pathogenesis, and propose TOLLIP as a promising therapeutic target.
Xiuhuan Jiang, Guoying Miao, Na Shen, Qingxia Han, Xiaoru Han, Zichang Qiao, Kexin Feng, Zhuo Tan, Yaguang Wang, Xiuhua Liu, Chen Wu, Zhenzhen Yan   +11 more
wiley   +1 more source

EphA2 regulates vascular permeability and prostate cancer metastasis via modulation of cell junction protein phosphorylation. [PDF]

Oncogene
Offenhäuser C, Dave KA, Beckett KJ, Smith FM, Jayakody BA, Cooper LT, Agyei-Yeboah H, McCarron JK, Li Y, Bastick K, Al-Ejeh F, Cullen JK, Coulthard MG, Gorman JJ, Boyd AW, Day BW.   +15 more
europepmc   +1 more source

Loss of E3 Ubiquitin Ligase RINES via CpG Methylation Relieves Suppression of STAT3 and MYC, Facilitating Multiple Tumorigeneses

Advanced Science, EarlyView.
Dysregulated protein modifications drive tumorigenesis. RINES, an E3 ubiquitin ligase, represses tumor cell proliferation and metastasis by facilitating RING domain‐dependent, ubiquitin–proteasome‐mediated degradation of STAT3 and MYC, which consequently restrains cancer stemness and oncogenic progression.
Lili Li, Ka Man Ng, Xingsheng Shu, Xiaoxue Chai, Kai Yau Wong, Gopesh Srivastava, Anthony T.C. Chan, Wai Yee Chan, Qian Tao   +8 more
wiley   +1 more source

Effects of cadherin mediated contact normalization on oncogenic Src kinase mediated gene expression and protein phosphorylation. [PDF]

Sci Rep
Nicoletto RE, Holdcraft CJ, Yin AC, Retzbach EP, Sheehan SA, Greenspan AA, Laugier CM, Trama J, Zhao C, Zheng H, Goldberg GS.   +10 more
europepmc   +1 more source

The TrkC-PTPσ complex governs synapse maturation and anxiogenic avoidance via synaptic protein phosphorylation. [PDF]

EMBO J
Khaled H, Ghasemi Z, Inagaki M, Patel K, Naito Y, Feller B, Yi N, Bourojeni FB, Lee AK, Chofflet N, Kania A, Kosako H, Tachikawa M, Connor S, Takahashi H.   +14 more
europepmc   +1 more source

Calorie restriction and rapamycin distinctly mitigate aging-associated protein phosphorylation changes in mouse muscles. [PDF]

Commun Biol
Ataman M, Mittal N, Tintignac L, Schmidt A, Ham DJ, González A, Ruegg MA, Zavolan M.   +7 more
europepmc   +1 more source

Dynamic Protein Phosphorylation in Streptococcus pyogenes during Growth, Stationary Phase, and Starvation. [PDF]

Microorganisms
Mikkat S, Kreutzer M, Patenge N.
europepmc   +1 more source