Results 111 to 120 of about 28,039,605 (307)

Multi-layered proteomics identifies insulin-induced upregulation of the EphA2 receptor via the ERK pathway which is dependent on low IGF1R level

Scientific Reports
Insulin resistance impairs the cellular insulin response, and often precedes metabolic disorders, like type 2 diabetes, impacting an increasing number of people globally.
Sarah Hyllekvist Jørgensen, Kristina Bennet Emdal, Anna-Kathrine Pedersen, Lene Nygaard Axelsen, Helene Faustrup Kildegaard, Damien Demozay, Thomas Åskov Pedersen, Mads Grønborg, Rita Slaaby, Peter Kresten Nielsen, Jesper Velgaard Olsen   +10 more
doaj   +1 more source

Computational Protein Design Force Field Optimization: A Negative Design Approach [PDF]

, 2007
An accurate force field is essential to computational protein design and protein folding studies. Proper force field tuning is problematic, however, due in part to the incomplete modeling of the unfolded state.
Alvizo, Oscar
core   +1 more source

Structural insights and therapeutic targets in Acinetobacter baumannii capsule biosynthesis

FEBS Letters, EarlyView.
Hypervirulent KL49 A. baumannii's capsular polysaccharide contains the nonulosonic acid 8‐epi‐Leg5,7Ac2, synthesized by epimerization via ElaA, ElaB, and ElaC. Crystal structures of ElaA, ElaB, and ElaC reveal their role in CMP‐Leg5,7Ac2 synthesis and regioselective C8 epimerization.
Woo Cheol Lee, Junho Jeong, Chae Yeong Lee, Hyunjoon Cho, Man Hwan Oh, Je Chul Lee, Jee‐Young Lee, Yangmee Kim   +7 more
wiley   +1 more source

Modelling stem cell differentiation related processes—A practical overview for biologists

FEBS Letters, EarlyView.
Stem cell differentiation is complex and difficult to control experimentally. This review introduces suitable computational modelling approaches that can support stem cell research, from mechanistic ODE and abstract models to multiscale and deep learning methods.
Ricco Zeegelaar, Xinqi Yan, Lucas F. Jansen Klomp, Stefano Schivo, Janine N. Post   +4 more
wiley   +1 more source

ABL kinase‐dependent phosphorylation of SH proteins promotes their direct interaction with CRK family SH2 domains

FEBS Letters, EarlyView.
CT10 regulator of kinase (CRK) and CRK‐Like (CRKL) are signaling adaptors driving cell adhesion, motility, differentiation, and proliferation. SH2‐domain containing (SH) proteins are enriched in YXXP motifs which when phosphorylated create preferred binding sites for CRK family SH2 domains.
Phoebe M. Cousens, Brendan W. Chandler, Anna M. Schmoker, Jaye L. Weinert, Charlotte A. Kearns, Warren T. Yacawych, Amila Šemić, Alicia M. Ebert, Bryan A. Ballif   +8 more
wiley   +1 more source

Domain discovery method for topological profile searches in protein structures [PDF]

, 2004
We describe a method for automated domain discovery for topological profile searches in protein structures. The method is used in a system TOPStructure for fast prediction of CATH classification for protein structures (given as PDB files).
Viksna, J, Gilbert, D, Torrance, G
core   +2 more sources

Redox-sensitivity and site-specificity of S- and N- denitrosation in proteins [PDF]

, 2010
Background S-nitrosation – the formation of S-nitrosothiols (RSNOs) at cysteine residues in proteins – is a posttranslational modification involved in signal transduction and nitric oxide (NO) transport.
Park Joo-Ho, Bhagavan Nadhipuram V., Fernandez Bernadette O., David Jourd'heuil, Ha Chung-Eun, Lowery Anthony M., Feelisch, Martin, Frances L Jourd'heuil, Sanie Mnaimneh, Jourd'heuil Frances L., Melton Elaina M., Bhagavan, Nadhipuram V., Chung-eun Ha, Martin Feelisch, Ha, Chung-Eun, Elaina M Melton, Fernandez, Bernadette O., Jourd'heuil David, Bauer, Joseph Alan, Feelisch Martin, Bryan, Nathan S., Jourd'heuil, David, Park, Joo-Ho, Nathan S Bryan, Nadhipuram V Bhagavan, Nadhipuram V. Bhagavan, Lowery, Anthony M., Melton, Elaina M., Anthony M. Lowery, Frances L. Jourd’heuil, Bernadette O Fernandez, Mnaimneh Sanie, Elaina M. Melton, Joo-ho Park, Anthony M Lowery, Bernadette O. Fern, Frances L. Jourd'heuil, Mnaimneh, Sanie, Nathan S. Bryan, Bryan Nathan S., Bernadette O. Fernandez, Jourd'heuil, Frances L.   +41 more
core   +2 more sources

Reconstructing enzyme evolution by protein engineering

FEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler, Markus R. Busch, Reinhard Sterner   +2 more
wiley   +1 more source

Mutational and functional analysis of N-linked glycosylation of envelope fusion protein F of Helicoverpa armigera nucleopolyhedrovirus [PDF]

, 2016
The envelope fusion (F) protein of baculoviruses is a heavily N-glycosylated protein that plays asignificant role in the virus infection cycle. N-Linked glycosylation of virus envelope glycoproteinis important for virus envelope glycoprotein folding and ...
Li, S., Wang, Hualin, Wang, Manli, van Oers, M.M., Wang, H., van Oers, Monique M, Vlak, J.M., Braakman, I., Deng, F., Li, Shufen, Deng, Fei, Cellular Protein Chemistry, Li, Xin, Wang, M., Vlak, Just M, Sub Cellular Protein Chemistry, Hu, Zhihong, Braakman, Ineke, Oers, M.M., van, Shen, Shu   +19 more
core   +2 more sources

Decoding the dynamic extracellular matrix in cancer—3D models and bioscaffolds rewire the rules of tumor progression

FEBS Letters, EarlyView.
Cancer progression is regulated by the dynamic matrix code of the tumor microenvironment, which influences cellular behavior and disease development. Importantly, matrix remodeling in three‐dimensional cancer models more accurately reflects in vivo conditions compared to conventional two‐dimensional systems.
Sylvia Mangani, Konstantinos Spanopoulos, Zoi Piperigkou, Nikos K. Karamanos   +3 more
wiley   +1 more source