Pyramidalization of the Glycosidic Nitrogen Provides the Way for Efficient Cleavage of the N‑Glycosidic Bond of 8‑OxoG with the hOGG1 DNA Repair Protein [PDF]
, 2012 A mechanistic pathway for cleavage of the N-glycosidic bond of 8-oxo-2′-deoxyguanosine (oxoG) catalyzed with the human 8-oxoguanine glycosylase 1 DNA repair protein (hOGG1) is proposed in this theoretical study. The reaction scheme suggests direct proton
Sychrovský, V. +5 more
core +1 more source
Local pre-processing for node classification in networks : application in protein-protein interaction [PDF]
, 2013 Network modelling provides an increasingly popular conceptualisation in a wide range of domains, including the analysis of protein structure. Typical approaches to analysis model parameter values at nodes within the network. The spherical locality around
Ross, Isla +4 more
core +4 more sources
Analytic framework for peptidomics applied to large-scale neuropeptide identification
Nature Communications, 2016 Neuropeptide research is challenged by technical difficulties in identifying new bioactive peptides. Here the authors present an analytical pipeline for large-scale peptidomics applied to the rat hypothalamus, identifying thousands of endogenous ...
Anna Secher +6 more
doaj +1 more source
Picky Hsp90-Every Game with Another Mate [PDF]
, 2017 In this issue of Molecular Cell, Sahasrabudhe et al. (2017) present a dramatically renovated functional cycle for the molecular chaperone Hsp90, which stimulates re-thinking of the mechanism of this vital protein folding ...
Sub Cellular Protein Chemistry +3 more
core +2 more sources
Role of Prothrombin and Methylenetetrahydrofolate Reductase Gene Polymorphisms as well as Thrombophilia Markers, as Risk Factors for Unexplained Recurrent Miscarriage: A Case-Control Study [PDF]
International Journal of Fertility and SterilityBackground: Unexplained recurrent miscarriage (RM) is still an unsolved reproductive health problem. Inheritedthrombophilias have been one of the causes.
Zeinab Ahmed Abd Elhameed +6 more
doaj +1 more source
Tuberculosis: Past, present and future of the treatment and drug discovery research
Current Research in Pharmacology and Drug Discovery, 2021 Tuberculosis (TB) is an infectious disease caused by the bacterium Mycobacterium tuberculosis. Despite decades of research driving advancements in drug development and discovery against TB, it still leads among the causes of deaths due to infectious ...
Ameya D. Bendre +2 more
doaj +1 more source
Heart and Mind, 2017 We report a case of a 36-year-old male presented with symptoms of chest pain and the electrocardiographic evidence of ST-segment elevation in inferior and anterior leads.
Huan Ma, Lan Guo
doaj +1 more source
The Physiology of ProteinS-acylation [PDF]
Physiological Reviews, 2015 Protein S-acylation, the only fully reversible posttranslational lipid modification of proteins, is emerging as a ubiquitous mechanism to control the properties and function of a diverse array of proteins and consequently physiological processes. S-acylation results from the enzymatic addition of long-chain lipids, most typically palmitate, onto ...
Chamberlain, Luke H. +1 more
openaire +5 more sources
A script to highlight hydrophobicity and charge on protein surfaces [PDF]
, 2015 The composition of protein surfaces determines both affinity and specificity of protein-protein interactions. Matching of hydrophobic contacts and charged groups on both sites of the interface are crucial to ensure specificity.
Tania eMorán Luengo +12 more
core +2 more sources
Universality in protein residue networks [PDF]
, 2010 Residue networks representing 595 nonhomologous proteins are studied. These networks exhibit universal topological characteristics as they belong to the topological class of modular networks formed by several highly interconnected clusters separated by ...
Estrada, Ernesto +1 more
core +4 more sources