Results 281 to 290 of about 220,067 (314)
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Protein sorting signals: Simple peptides with complex functions
1995Protein sorting signals provide good examples of peptides that can be studied both from a chemical and a biochemical perspective. Their simple designs and low degree of sequence conservation suggest that they are involved in rather non-specific peptide-lipid interactions, yet their ability to discriminate efficiently between the import machineries of ...
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Using sorting signals to retain proteins in endoplasmic reticulum
2000Publisher Summary This chapter describes the use of sorting signals to retain proteins in endoplasmic reticulum. It is desirable to express an altered form of a secreted or membrane protein such that it remains in the endoplasmic reticulum (ER). This approach can be used to accumulate high levels of a particular protein, to test whether the location ...
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Sorting signals can direct receptor-mediated export of soluble proteins into COPII vesicles
Nature Cell Biology, 2004Soluble secretory proteins are first translocated across endoplasmic reticulum (ER) membranes and folded in a specialized ER luminal environment. Fully folded and assembled secretory cargo are then segregated from ER-resident proteins into COPII-derived vesicles or tubular elements for anterograde transport.
Stefan, Otte, Charles, Barlowe
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Protein Sorting Signals for Maintaining Transmembrane Proteins in the Endoplasmatic Reticulum
1994Trafficking and sorting of proteins through the central organellar system has been a focus of interst since Palade (1975) and co-workers formulated the general outline of the secretory pathway. The basics of this pathway are now well established. Nascent proteins are targeted to the first organelle of this pathway, the endoplasmic reticulum, via a ...
M. R. Jackson, P. A. Peterson
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Sorting signals from protein NMR spectra: SPI, a Bayesian protocol for uncovering spin systems
Journal of Biomolecular NMR, 2002Grouping of spectral peaks into J-connected spin systems is essential in the analysis of macromolecular NMR data as it provides the basis for disentangling chemical shift degeneracies. It is a mandatory step before resonance and NOESY cross-peak identities can be established.
Alexander, Grishaev, Miguel, Llinás
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Annual Review of Cell and Developmental Biology, 1996
Each organelle of the secretory pathway is required to selectively allow transit of newly synthesized secretory and plasma membrane proteins and also to maintain a unique set of resident proteins that define its structural and functional properties.
Teasdale, RD, Jackson, MR
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Each organelle of the secretory pathway is required to selectively allow transit of newly synthesized secretory and plasma membrane proteins and also to maintain a unique set of resident proteins that define its structural and functional properties.
Teasdale, RD, Jackson, MR
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Signals and mechanisms implicated in the apical sorting of small intestinal proteins
2002[no abstract]
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The contemporary management of cancers of the sinonasal tract in adults
Ca-A Cancer Journal for Clinicians, 2023Rajat Thawani
exaly
Mechanisms of signal-mediated protein sorting in the endocytic and secretory pathways.
Proceedings of the Association of American Physicians, 1997The ability to sort proteins to different intracellular compartments is an essential property of all cells. Many diseases are caused by a failure of certain proteins to be sorted properly in the endocytic and secretory pathways. In addition, various intracellular pathogens use their hosts' protein-sorting machinery at different stages of their life ...
J S, Bonifacino +3 more
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PROTAC targeted protein degraders: the past is prologue
Nature Reviews Drug Discovery, 2022Miklos Bekes +2 more
exaly