Results 91 to 100 of about 2,449,011 (263)

Novel antioxidant protein target therapy to counter the prevalence and severity of SARS-CoV-2. [PDF]

Front Immunol, 2023
Kaur P, Dey A, Rawat K, Dey S.
europepmc   +1 more source

Microbiome−host proteostasis crosstalk—An emerging perspective on mechanisms and interventions toward healthy longevity

FEBS Letters, EarlyView.
Proteostasis and the gut microbiota play a key role in shaping host physiology. Microbiota‐derived metabolites, vitamins, and RNA modulate host proteostasis. Findings from model systems, including C. elegans, indicate microbes can either stabilize or disrupt host proteostasis.
Abhishek Anil Dubey, Maria Ermolaeva
wiley   +1 more source

Oncogenic mutations of KRAS modulate its turnover by the CUL3/LZTR1 E3 ligase complex

Life Science Alliance
The study reveals how KRAS mutations disrupt LZTR1-mediated KRAS degradation, shedding light on potential mechanisms in oncogenesis. KRAS is a proto-oncogene encoding a small GTPase.
Andreas Damianou, Zhu Liang, Frederik Lassen, Iolanda Vendrell, George Vere, Svenja Hester, Philip D Charles, Adan Pinto-Fernandez, Alberto Santos, Roman Fischer, Benedikt M Kessler   +10 more
doaj   +1 more source

Deep generative model for drug design from protein target sequence. [PDF]

J Cheminform, 2023
Chen Y, Wang Z, Wang L, Wang J, Li P, Cao D, Zeng X, Ye X, Sakurai T.   +8 more
europepmc   +1 more source

From mice to humans—divergent strategies for intestinal homeostasis and regeneration

FEBS Letters, EarlyView.
Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa, Shinya Sugimoto, Toshiro Sato   +2 more
wiley   +1 more source

AlphaDrug: protein target specific de novo molecular generation. [PDF]

PNAS Nexus, 2022
Qian H, Lin C, Zhao D, Tu S, Xu L.
europepmc   +1 more source

Phosphoinositides and inositol phosphates as molecular glues

FEBS Letters, EarlyView.
Inositol phosphates (IPs) and phosphoinositides (PIPs) regulate diverse eukaryotic processes. Beyond recruiting signaling proteins or acting as structural cofactors, recent studies suggest they mediate protein–protein interactions as natural molecular glues.
Aleshia Seaton‐Terry, Alexander J. Cutright, Mong Na Claire Loi, Jessica Martin, Joseph W. Gilligan, Jakub N. Kubina, Michael J. Arambula, Susanna Tanada Palmu, Daniella Zhou, Raymond D. Blind   +9 more
wiley   +1 more source

SE(3)-equivariant ternary complex prediction towards target protein degradation

Nature Communications
Targeted protein degradation (TPD) has rapidly emerged as a powerful modality for drugging previously “undruggable” proteins. TPD employs small molecules like PROTACs and molecular glue degraders (MGD) to induce target protein degradation via the ...
Fanglei Xue, Meihan Zhang, Shuqi Li, Xinyu Gao, James A. Wohlschlegel, Wenbing Huang, Yi Yang, Weixian Deng   +7 more
doaj   +1 more source

SARS-CoV-2 nonstructural protein 3 remodels the phosphorylation of target proteins via protein-protein interactions

Microbiology Spectrum
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the causative agent of coronavirus disease 2019 (COVID-19), triggered a global pandemic with a significant impact on human health. The molecular basis of its pathogenicity remains incompletely
Hui Yang, Daxin Peng, Luis Martinez-Sobrido, Chengjin Ye   +3 more
doaj   +1 more source

Prediction of Novel Natural Small Molecules From Schinus molle as an Inhibitor of PI3K Protein Target in Cancer Cells Using In Silico Screening. [PDF]

Cureus, 2023
Kumar U, Manivannan HP, Francis AP, Veeraraghavan VP, R G, Sankaran K.   +5 more
europepmc   +1 more source