Results 291 to 300 of about 3,768,680 (342)

Tumor‐stromal crosstalk and macrophage enrichment are associated with chemotherapy response in bladder cancer

FEBS Open Bio, EarlyView.
Chemoresistance in bladder cancer: Macrophage recruitment associated with CXCL1, CXCL5 and CXCL8 expression is characteristic of Gemcitabine/Cisplatin (Gem/Cis) Non‐Responder tumors (right side) while Responder tumors did not show substantial tumor‐stromal crosstalk (left side). All biological icons are attributed to Bioicons: carcinoma, cancerous‐cell‐
Sophie Leypold, Janik Riese, Lancelot Seillier, Mark Kühnel, Julia Pannhausen, Charlotte O. J. Fröhlich, Christian Martin, Peter Boor, Matthias Saar, Danny D. Jonigk, Nadine T. Gaisa, Michael Rose   +11 more
wiley   +1 more source

Discovery of New Hydroxyethylamine Analogs Against 3CLpro Protein Target of SARS-CoV-2: Molecular Docking, Molecular Dynamics Simulation and Structure-Activity Relationship Studies

, 2020
Kumar S, Sharma PP, Shankar U, Kumar D, Joshi SK, Pena L, Durvasula R, Kumar A, Kempaiah P, null P, Rathi B.   +10 more
europepmc   +1 more source

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Protein targeting to peroxisomes

Biochemical Society Transactions, 1990
Peroxisomes are single-membrane-bound organelles that have important functions in cell metabolism. They are almost ubiquitous in eukaryotic cells and biochemical findings over the past 10 years have shown that they are involved in cell respiration, and also play a significant role in lipid metabolism (for reviews, see [ l , 21).
G M, Small, A S, Lewin
openaire   +2 more sources

Targeting of proteins into chloroplasts

BioEssays, 1988
AbstractCytoplasmically synthesized proteins are directed into chloroplasts by amino terminal transit sequences of the precursor proteins. For proteins of the thylakoid lumen, transit sequences are also important in directing proteins to the lumen.
K, Keegstra, C, Bauerle
openaire   +2 more sources

Targeting of lysosomal proteins

Seminars in Cell & Developmental Biology, 2000
Proper cell homeostasis requires the efficient transport of a large variety of soluble acid hydrolases and transmembrane proteins from the trans-Golgi network (TGN) to lysosomes. While most of these molecules reach this degradative compartment, some transmembrane proteins, in particular, the acid hydrolase receptors are retrieved to the TGN.
Y, Rouillé, W, Rohn, B, Hoflack
openaire   +2 more sources

Targeting of Motor Proteins

Science, 1996
Microtubules are responsible for chromosome segregation and the movement and reorganization of membranous organelles. Many aspects of microtubule-based motility can be attributed to the action of motor proteins, producing force directed toward either end of microtubules.
R B, Vallee, M P, Sheetz
openaire   +2 more sources

Protein Targeting in the Neuron

Annual Review of Neuroscience, 1993
The morphology of the neuron is essential to its function. Each mor­ phological specialization of the neuron, the dendrite, the dendritic spines, the axon, the axon hillock, the nodes of Ranvier, the active zone, and the synaptic vesicle appears to have a unique protein composition.
R B, Kelly, E, Grote
openaire   +2 more sources

Protein targeting and protein secretion

Genome, 1989
The two scheduled workshops entitled Protein Secretion and Protein Targeting were combined into a single session on Monday, August 22, before a large audience. We record here the highlights of these talks, which supplement the information already available in the published abstracts.
M E, Dumont, F, Sherman, D Y, Thomas
openaire   +2 more sources

Proteolysis-targeting Chimeras for Targeting Protein for Degradation

Future Medicinal Chemistry, 2019
Proteolysis-targeting chimeras (PROTACs) are an emerging tool for therapeutic intervention by reducing or eliminating disease-causing proteins. PROTACs are bifunctional molecules that consist of a target protein ligand, a linker and an E3 ligase ligand, which mediate the polyubiquitination of the target protein, ultimately leading to the target protein
Jianguo, Qi, Gang, Zhang
openaire   +2 more sources

Protein–Protein Interactions as Drug Targets

Future Medicinal Chemistry, 2015
Modulation of protein-protein interactions (PPIs) is becoming increasingly important in drug discovery and chemical biology. While a few years ago this 'target class' was deemed to be largely undruggable an impressing number of publications and success stories now show that targeting PPIs with small, drug-like molecules indeed is a feasible approach ...
Skwarczynska, Malgorzata, Ottmann, Christian   +1 more
openaire   +2 more sources