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Current Opinion in Chemical Biology, 2005
The ubiquitin-proteasome pathway plays a major role in cellular protein destruction and regulates fundamental cellular processes such as the cell cycle, cell signaling, and development. By altering the substrate recognition of ubiquitin-protein ligases, their robust proteolytic activity can be re-directed to recruit and accelerate the degradation of ...
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The ubiquitin-proteasome pathway plays a major role in cellular protein destruction and regulates fundamental cellular processes such as the cell cycle, cell signaling, and development. By altering the substrate recognition of ubiquitin-protein ligases, their robust proteolytic activity can be re-directed to recruit and accelerate the degradation of ...
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On‐target ultrasonic digestion of proteins
PROTEOMICS, 2013In the present work, we report a novel on‐target protein cleavage method. The method utilizes ultrasonic energy and allows up to 20 samples to be cleaved in 5 min for protein identification and one sample in 30 s for on‐tissue digestion. The standard proteins were spotted on a conductive glass slide in a volume of 0.5 μL followed by 5 min of ...
Santos, Hugo M. +3 more
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Targeting malaria protein kinases
2021Malaria is one of the most impacting public health problems in tropical and subtropical areas of the globe, with approximately 200 million cases worldwide annually. In the absence of an effective vaccine, rapid treatment is vital for effective malaria control.
G C, Cassiano +6 more
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Drugs Targeting Protein—Protein Interactions
ChemInform, 2006AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
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Protein Targeting to Yeast Peroxisomes
2007Peroxisomes are important organelles of eukaryote cells. Although these structures are of relatively small size, they display an unprecedented functional versatility. The principles of their biogenesis and function are strongly conserved from very simple eukaryotes to humans.
van der Klei, Ida, Veenhuis, Marten
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Targeting and Insertion of Membrane Proteins
EcoSal Plus, 2017The insertion and assembly of proteins into the inner membrane of bacteria are crucial for many cellular processes, including cellular respiration, signal transduction, and ion and pH homeostasis. This process requires efficient membrane targeting and insertion of proteins into the lipid bilayer in their correct orientation and proper ...
Kuhn, Andreas +2 more
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Targeted protein degradation mechanisms
Drug Discovery Today: Technologies, 2019Targeted protein degradation mediated by small molecule degraders represents an exciting new therapeutic opportunity to eliminate disease-causing proteins. These molecules recruit E3 ubiquitin ligases to the protein of interest and mediate its ubiquitination and subsequent proteolysis by the proteasome.
Yi, Zhang +3 more
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Antibiotics that target protein synthesis
WIREs RNA, 2010AbstractThe key role of the bacterial ribosome makes it an important target for antibacterial agents. Indeed, a large number of clinically useful antibiotics target this complex translational ribonucleoprotein machinery. The majority of these compounds, mostly of natural origin, bind to one of the three key ribosomal sites: the decoding (or A‐site) on ...
Lisa S, McCoy, Yun, Xie, Yitzhak, Tor
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1996
Abstract Protein targeting is the study of how proteins synthesized in one part of the cell reach their ultimate destination. A cell may have to guide a protein through several membranes into one of its organelles, or take up or secrete a protein through its cell wall. This book is a preview of the latest research in this area, which has
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Abstract Protein targeting is the study of how proteins synthesized in one part of the cell reach their ultimate destination. A cell may have to guide a protein through several membranes into one of its organelles, or take up or secrete a protein through its cell wall. This book is a preview of the latest research in this area, which has
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1992
Abstract It has been known for many years that the subcellular distribution of proteins throughout eukaryotic cells is highly ordered. This means that proteins have to be transported to their correct destinations and left there. Understanding the complex mechanisms by which this occurs has provided a major challenge for modern biology ...
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Abstract It has been known for many years that the subcellular distribution of proteins throughout eukaryotic cells is highly ordered. This means that proteins have to be transported to their correct destinations and left there. Understanding the complex mechanisms by which this occurs has provided a major challenge for modern biology ...
openaire +1 more source